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Review Article

钌金属治疗学：对抗寄生虫感染的新方法

卷 29, 期 31, 2022

发表于: 10 June, 2022

页: [5159 - 5178] 页: 20

弟呕挨: 10.2174/0929867329666220401105444

价格: $65

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摘要

人类寄生虫感染导致全球每年超过100万人的死亡率，是一些最具挑战性的医疗干预疾病。目前的化疗策略通常需要长期治疗，再加上随后药物诱导的宿主细胞毒性发病率，而耐药性的产生也是一个主要问题。金属在整个医学史上得到了广泛的应用，最近的应用是作为抗癌和抗菌剂。钌金属治疗抗寄生虫剂在针对一系列关键寄生虫方面非常有效，包括疟疾、锥虫病、利什曼病、阿米巴病、弓形虫病和其他孤儿病的致病因子，同时显示出比目前治疗策略更低的细胞毒性。一般来说，这类化合物还表现出对寄生虫内多个细胞靶点的活性，包括对酶功能的抑制、细胞膜的扰动和对代谢途径的改变，因此减少了抗药性产生的机会。这篇综述在合理药物设计和潜在的临床方法方面，对快速发展的钌金属基抗寄生虫化学疗法领域进行了全面和主观的分析，以对抗人类寄生虫感染。

关键词: 抗寄生虫，钌，疟疾，锥虫病，利什曼病，阿米巴病，金属治疗，寄生虫感染。

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