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Mini-Reviews in Medicinal Chemistry

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ISSN (Online): 1875-5607

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Mini-Review Article

Benzimidazoles Against Certain Breast Cancer Drug Targets: A Review

Author(s): Mehmet Murat Kisla and Zeynep Ates-Alagoz*

Volume 22, Issue 19, 2022

Published on: 23 May, 2022

Page: [2463 - 2477] Pages: 15

DOI: 10.2174/1389557522666220328161217

Price: $65

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Abstract

Background: Benzimidazoles are widely used scaffolds against various types of cancer, including breast cancer. To this end, anticancer agents must be developed using the knowledge of the specific targets of BC.

Objective: In this study, we aim to review the compounds used against some of the biomolecular targets of breast cancer. To this end, we present information about the various targets, with their latest innovative studies.

Conclusion: Benzimidazole ring is an important building block that can target diverse cancer scenarios since it can structurally mimic biomolecules in the human body. Additionally, many studies imply the involvement of this moiety on a plethora of pathways and enzymes related to BC. Herein, our target- based collection of benzimidazole derivatives strongly suggests the utilization of benzimidazole derivatives against BC.

Keywords: Anticancer drugs, benzimidazoles, target-based biomolecules, pathways, plethora of pathways, breast cancer.

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