Abstract
There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
Keywords: Wnt, β-catenin, signaling, dysregulation, cancer, therapy
Current Drug Targets
Title: The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy
Volume: 9 Issue: 7
Author(s): Kenneth B.R. Ewan and Trevor C. Dale
Affiliation:
Keywords: Wnt, β-catenin, signaling, dysregulation, cancer, therapy
Abstract: There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.
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Cite this article as:
Ewan B.R. Kenneth and Dale C. Trevor, The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy, Current Drug Targets 2008; 9 (7) . https://dx.doi.org/10.2174/138945008784911787
DOI https://dx.doi.org/10.2174/138945008784911787 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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