Generic placeholder image

Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

The Potential for Targeting Oncogenic WNT/β -Catenin Signaling in Therapy

Author(s): Kenneth B.R. Ewan and Trevor C. Dale

Volume 9, Issue 7, 2008

Page: [532 - 547] Pages: 16

DOI: 10.2174/138945008784911787

Price: $65

Abstract

There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.

Keywords: Wnt, β-catenin, signaling, dysregulation, cancer, therapy


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy