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Current Aging Science

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ISSN (Print): 1874-6098
ISSN (Online): 1874-6128

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Research Article

Dietary Acid Load Associated with Hypertension and Diabetes in the Elderly

Author(s): Tulay Omma*, Nese Ersoz Gulcelik, Fatmanur Humeyra Zengin, Irfan Karahan and Cavit Culha

Volume 15, Issue 3, 2022

Published on: 20 May, 2022

Page: [242 - 251] Pages: 10

DOI: 10.2174/1874609815666220328123744

Price: $65

Abstract

Background: Diet can affect the body's acid-base balance due to its content of acid or base precursors. There is conflicting evidence for the role of metabolic acidosis in the development of cardiometabolic disorders, hypertension (HT), and insulin resistance (IR).

Objective: We hypothesized that dietary acid load (DAL) is associated with adverse metabolic risk factors and aimed to investigate this in the elderly.

Methods: A total of 114 elderly participants were included in the study. The participants were divided into four groups, such as HT, diabetes (DM), both HT and DM, and healthy controls. Anthropometric, biochemical, and clinical findings were recorded. Potential renal acid load (PRAL) and net endogenous acid production (NEAP) results were obtained for three days, 24-hour dietary records via a nutrient database program (BeBiS software program).

Results: The groups were matched for age, gender, and BMI. There was a statistically significant difference between the groups regarding NEAP (p =0.01) and no significant difference for PRAL ( p = 0.086). The lowest NEAP and PRAL levels were seen in the control group while the highest in the HT group. Both NEAP and PRAL were correlated with waist circumference (r = 0,325, p = 0.001; r=0,231, p =0,016, respectively).

Conclusion: Our data confirmed that subjects with HT and DM had diets with greater acid-forming potential. High NEAP may be a risk factor for chronic metabolic diseases, particularly HT. PRAL could not be shown as a significantly different marker in all participants. Dietary content has a significant contribution to the reduction of cardiovascular risk factors, such as HT, DM, and obesity.

Keywords: Dietary acid load, diabetes, hypertension, potential renal acid load, net endogenous acid production, insulin resistance.

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[1]
Han H, Fang X, Wei X, et al. Dose-response relationship between dietary magnesium intake, serum magnesium concentration and risk of hypertension: A systematic review and meta-analysis of prospective cohort studies. Nutr J 2017; 16(1): 26.
[http://dx.doi.org/10.1186/s12937-017-0247-4] [PMID: 28476161]
[2]
GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mor-tality for 240 causes of death, 1990-2013: A systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015; 385(9963): 117-71.
[http://dx.doi.org/10.1016/S0140-6736(14)61682-2] [PMID: 25530442]
[3]
Laiteerapong N, Karter AJ, Liu JY, et al. Correlates of quality of life in older adults with diabetes: The diabetes & aging study. Diabetes Care 2011; 34(8): 1749-53.
[http://dx.doi.org/10.2337/dc10-2424] [PMID: 21636795]
[4]
Chuang SY, Chiu TH, Lee CY, et al. Vegetarian diet reduces the risk of hypertension independent of abdominal obesity and inflammation: A prospective study. J Hypertens 2016; 34(11): 2164-71.
[http://dx.doi.org/10.1097/HJH.0000000000001068] [PMID: 27512965]
[5]
Akter S, Eguchi M, Kurotani K, et al. High dietary acid load is associated with increased prevalence of hypertension: The Furukawa Nutri-tion and Health Study. Nutrition 2015; 31(2): 298-303.
[http://dx.doi.org/10.1016/j.nut.2014.07.007] [PMID: 25592007]
[6]
Remer T. Influence of nutrition on acid-base balance--metabolic aspects. Eur J Nutr 2001; 40(5): 214-20.
[http://dx.doi.org/10.1007/s394-001-8348-1] [PMID: 11842946]
[7]
Ley SH, Ardisson Korat AV, Sun Q, et al. Contribution of the nurses’ health studies to uncovering risk factors for type 2 diabetes: Diet, lifestyle, biomarkers, and genetics. Am J Public Health 2016; 106(9): 1624-30.
[http://dx.doi.org/10.2105/AJPH.2016.303314] [PMID: 27459454]
[8]
Mandel EI, Taylor EN, Curhan GC. Dietary and lifestyle factors and medical conditions associated with urinary citrate excretion. Clin J Am Soc Nephrol 2013; 8(6): 901-8.
[http://dx.doi.org/10.2215/CJN.07190712] [PMID: 23449767]
[9]
Adeva MM, Souto G. Diet-induced metabolic acidosis. Clin Nutr 2011; 30(4): 416-21.
[http://dx.doi.org/10.1016/j.clnu.2011.03.008] [PMID: 21481501]
[10]
van Nielen M, Feskens EJ, Mensink M, et al. InterAct Consortium. Dietary protein intake and incidence of type 2 diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care 2014; 37(7): 1854-62.
[http://dx.doi.org/10.2337/dc13-2627] [PMID: 24722499]
[11]
Malik VS, Li Y, Tobias DK, Pan A, Hu FB. Dietary protein intake and risk of type 2 diabetes in US men and women. Am J Epidemiol 2016; 183(8): 715-28.
[http://dx.doi.org/10.1093/aje/kwv268] [PMID: 27022032]
[12]
Engberink MF, Bakker SJ, Brink EJ, et al. Dietary acid load and risk of hypertension: The Rotterdam Study. Am J Clin Nutr 2012; 95(6): 1438-44.
[http://dx.doi.org/10.3945/ajcn.111.022343] [PMID: 22552032]
[13]
Murakami K, Livingstone MBE, Okubo H, Sasaki S. Higher dietary acid load is weakly associated with higher adiposity measures and blood pressure in Japanese adults: The National Health and Nutrition Survey. Nutr Res 2017; 44: 67-75.
[http://dx.doi.org/10.1016/j.nutres.2017.06.005] [PMID: 28821319]
[14]
Lucas PA, Lacour B, McCarron DA, Drüeke T. Disturbance of acid-base balance in the young spontaneously hypertensive rat. Clin Sci (Lond) 1987; 73(2): 211-5.
[http://dx.doi.org/10.1042/cs0730211] [PMID: 3652625]
[15]
Scialla JJ, Anderson CA. Dietary acid load: A novel nutritional target in chronic kidney disease? Adv Chronic Kidney Dis 2013; 20(2): 141-9.
[http://dx.doi.org/10.1053/j.ackd.2012.11.001] [PMID: 23439373]
[16]
Alam I, Alam I, Paracha PI, Pawelec G. Higher estimates of daily dietary net endogenous acid production (NEAP) in the elderly as com-pared to the young in a healthy, free-living elderly population of Pakistan. Clin Interv Aging 2012; 7: 565-73.
[http://dx.doi.org/10.2147/CIA.S37158] [PMID: 23271903]
[17]
Remer T, Manz F. Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. Am J Clin Nutr 1994; 59(6): 1356-61.
[http://dx.doi.org/10.1093/ajcn/59.6.1356] [PMID: 8198060]
[18]
Frassetto LA, Todd KM, Morris RC Jr, Sebastian A. Estimation of net endogenous noncarbonic acid production in humans from diet po-tassium and protein contents. Am J Clin Nutr 1998; 68(3): 576-83.
[http://dx.doi.org/10.1093/ajcn/68.3.576] [PMID: 9734733]
[19]
American Diabetes Association. Classification and diagnosis of diabetes: Standards of medical care in diabetes-2019. Diabetes Care 2019; 42(Suppl. 1): S13-28.
[http://dx.doi.org/10.2337/dc19-S002] [PMID: 30559228]
[20]
Alam I, Larbi A, Pawelec G, Paracha PI. Relationship between anthropometric variables and nutrient intake in apparently healthy male elderly individuals: A study from Pakistan 2011; 10: 111.
[21]
Ebispro for Windows, Stuttgart, Germany; Turkish Version (BeBiS 8.2), Pasifik Elektirik Elektronik Ltd. Şti. (www.bebis.com.tr); Istanbul. 2019.2019. Available from: www.bebis.com.tr
[22]
Reddy ST, Wang CY, Sakhaee K, Brinkley L, Pak CY. Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism. Am J Kidney Dis 2002; 40(2): 265-74.
[http://dx.doi.org/10.1053/ajkd.2002.34504] [PMID: 12148098]
[23]
Krupp D, Esche J, Mensink GBM, Klenow S, Thamm M, Remer T. Dietary acid load and potassium intake associate with blood pressure and hypertension prevalence in a representative sample of the German adult population. Nutrients 2018; 10(1): E103.
[http://dx.doi.org/10.3390/nu10010103] [PMID: 29351232]
[24]
Incollingo RAC, Epel ES, White ML, Standen EC, Seckl JR, Tomiyama AJ. Hypothalamic-pituitary-adrenal axis dysregulation and cortisol activity in obesity: A systematic review. Psychoneuroendocrinology 2015; 62: 301-18.
[http://dx.doi.org/10.1016/j.psyneuen.2015.08.014] [PMID: 26356039]
[25]
Kiefte-de Jong JC, Li Y, Chen M, et al. Diet-dependent acid load and type 2 diabetes: Pooled results from three prospective cohort studies. Diabetologia 2017; 60(2): 270-9.
[http://dx.doi.org/10.1007/s00125-016-4153-7] [PMID: 27858141]
[26]
Chan R, Wong VW, Chu WC, et al. Higher estimated net endogenous Acid production may be associated with increased prevalence of nonalcoholic Fatty liver disease in Chinese adults in Hong Kong. PLoS One 2015; 10(4): e0122406.
[http://dx.doi.org/10.1371/journal.pone.0122406] [PMID: 25905490]
[27]
Krupp D, Shi L, Remer T. Longitudinal relationships between diet-dependent renal acid load and blood pressure development in healthy children. Kidney Int 2014; 85(1): 204-10.
[http://dx.doi.org/10.1038/ki.2013.331] [PMID: 24025638]
[28]
Wang J, Qin T, Chen J, et al. Hyperuricemia and risk of incident hypertension: A systematic review and meta-analysis of observational studies. PLoS One 2014; 9(12): e114259.
[http://dx.doi.org/10.1371/journal.pone.0114259] [PMID: 25437867]
[29]
Dehghan P, Abbasalizad Farhangi M. Dietary acid load, blood pressure, fasting blood sugar and biomarkers of insulin resistance among adults: Findings from an updated systematic review and meta-analysis. Int J Clin Pract 2020; 74(4): e13471.
[http://dx.doi.org/10.1111/ijcp.13471] [PMID: 31884719]
[30]
Chen SW, Chen ZH, Liang YH, Wang P, Peng JW. Elevated hypertension risk associated with higher dietary acid load: A systematic review and meta-analysis. Clin Nutr ESPEN 2019; 33: 171-7.
[http://dx.doi.org/10.1016/j.clnesp.2019.05.020] [PMID: 31451256]
[31]
Daneshzad E, Haghighatdoost F, Azadbakht L. Dietary acid load and cardiometabolic risk factors: A systematic review and meta-analysis of observational studies. Public Health Nutr 2019; 22(15): 2823-34.
[http://dx.doi.org/10.1017/S1368980019001125] [PMID: 31124769]
[32]
Zhang L, Curhan GC, Forman JP. Diet-dependent net acid load and risk of incident hypertension in United States women. Hypertension 2009; 54(4): 751-5.
[http://dx.doi.org/10.1161/HYPERTENSIONAHA.109.135582] [PMID: 19667248]
[33]
Fagherazzi G, Vilier A, Bonnet F, et al. Dietary acid load and risk of type 2 diabetes: The E3N-EPIC cohort study. Diabetologia 2014; 57(2): 313-20.
[http://dx.doi.org/10.1007/s00125-013-3100-0] [PMID: 24232975]
[34]
Akter S, Eguchi M, Kuwahara K, et al. High dietary acid load is associated with insulin resistance: The Furukawa Nutrition and Health Study. Clin Nutr 2016; 35(2): 453-9.
[http://dx.doi.org/10.1016/j.clnu.2015.03.008] [PMID: 25863769]
[35]
Akter S, Kurotani K, Kashino I, et al. Japan Public Health Center-based Prospective Study Group. High dietary acid load score is associat-ed with increased risk of type 2 diabetes in japanese men: The Japan Public health center-based prospective study. J Nutr 2016; 146(5): 1076-83.
[http://dx.doi.org/10.3945/jn.115.225177] [PMID: 27052540]
[36]
Arisawa K, Katsuura-Kamano S, Uemura H, et al. Association of dietary acid load with the prevalence of metabolic syndrome among participants in baseline survey of the japan multi-institutional collaborative Cohort Study. Nutrients 2020; 12(6): 1605.
[http://dx.doi.org/10.3390/nu12061605] [PMID: 32486113]
[37]
Amodu A, Abramowitz MK. Dietary acid, age, and serum bicarbonate levels among adults in the United States. Clin J Am Soc Nephrol 2013; 8(12): 2034-42.
[http://dx.doi.org/10.2215/CJN.03600413] [PMID: 24052219]
[38]
Chen SW, Ji GY, Jiang Q, et al. Association between dietary acid load and the risk of hypertension among adults from South China: Result from nutrition and health survey (2015-2017). BMC Public Health 2019; 19(1): 1599.
[http://dx.doi.org/10.1186/s12889-019-7985-5] [PMID: 31783746]
[39]
Stone MS, Martyn L, Weaver CM. Potassium intake, bioavailability, hypertension, and glucose control. Nutrients 2016; 8(7): E444.
[http://dx.doi.org/10.3390/nu8070444] [PMID: 27455317]
[40]
Champagne CM. Dietary interventions on blood pressure: The Dietary Approaches to Stop Hypertension (DASH) trials. Nutr Rev 2006; 64(2 Pt 2): S53-6.
[http://dx.doi.org/10.1111/j.1753-4887.2006.tb00234.x] [PMID: 16532899]
[41]
Institute of Medicine (IOM). Food and nutrition board dietary reference intakes: Calcium, phosphorus, magnesium, vitamin D and fluo-ride. Washington, DC: National Academy Press 1997.
[42]
Ross AC, Taylor CL, Yaktine AL, Del Valle HB. Committee to review dietary reference intakes for vitamin D and calcium, institute of medicine Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academy Press 2011.
[43]
Aleixandre A, Miguel M. Dietary fiber and blood pressure control. Food Funct 2016; 7(4): 1864-71.
[http://dx.doi.org/10.1039/C5FO00950B] [PMID: 26923351]
[44]
Zeisel SH. Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis. Clin Chem Lab Med 2013; 51(3): 467-75.
[http://dx.doi.org/10.1515/cclm-2012-0518] [PMID: 23072856]
[45]
Yang JJ, Lipworth LP, Shu XO, et al. Associations of choline-related nutrients with cardiometabolic and all-cause mortality: Results from 3 prospective cohort studies of blacks, whites, and Chinese. Am J Clin Nutr 2020; 111(3): 644-56.
[http://dx.doi.org/10.1093/ajcn/nqz318] [PMID: 31915809]
[46]
Golzarand M, Bahadoran Z, Mirmiran P, Azizi F. Dietary choline and betaine intake and risk of hypertension development: A 7.4-year follow-up. Food Funct 2021; 12(9): 4072-8.
[http://dx.doi.org/10.1039/D0FO03208E] [PMID: 33977970]
[47]
Zhao G, He F, Wu C, et al. Betaine in inflammation: Mechanistic aspects and applications. Front Immunol 2018; 9: 1070.
[http://dx.doi.org/10.3389/fimmu.2018.01070] [PMID: 29881379]
[48]
Zheng Y, Li Y, Rimm EB, et al. Dietary phosphatidylcholine and risk of all-cause and cardiovascular-specific mortality among US women and men. Am J Clin Nutr 2016; 104(1): 173-80.
[http://dx.doi.org/10.3945/ajcn.116.131771] [PMID: 27281307]
[49]
Liu RH. Health-promoting components of fruits and vegetables in the diet. Adv Nutr 2013; 4(3): 384S-92S.
[http://dx.doi.org/10.3945/an.112.003517] [PMID: 23674808]
[50]
Zhang Y, Bi J, Huang J, Tang Y, Du S, Li P. Exosome: A review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications. Int J Nanomedicine 2020; 15: 6917-34.
[http://dx.doi.org/10.2147/IJN.S264498] [PMID: 33061359]
[51]
Raimondo S, Naselli F, Fontana S, et al. Citrus limon-derived nanovesicles inhibit cancer cell proliferation and suppress CML xenograft growth by inducing TRAIL-mediated cell death. Oncotarget 2015; 6(23): 19514-27.
[http://dx.doi.org/10.18632/oncotarget.4004] [PMID: 26098775]
[52]
Blackwood RA, Smolen JE, Transue A, et al. Phospholipase D activity facilitates Ca2+-induced aggregation and fusion of complex lipo-somes. Am J Physiol 1997; 272(4 Pt 1): C1279-85.
[http://dx.doi.org/10.1152/ajpcell.1997.272.4.C1279] [PMID: 9142853]
[53]
Mu J, Zhuang X, Wang Q, et al. Interspecies communication between plant and mouse gut host cells through edible plant derived exo-some-like nanoparticles. Mol Nutr Food Res 2014; 58(7): 1561-73.
[http://dx.doi.org/10.1002/mnfr.201300729] [PMID: 24842810]
[54]
Zhuang X, Deng ZB, Mu J, et al. Ginger-derived nanoparticles protect against alcohol-induced liver damage. J Extracell Vesicles 2015; 4(1): 28713.
[http://dx.doi.org/10.3402/jev.v4.28713] [PMID: 26610593]
[55]
Koeberle A, Werz O. Multi-target approach for natural products in inflammation. Drug Discov Today 2014; 19(12): 1871-82.
[http://dx.doi.org/10.1016/j.drudis.2014.08.006] [PMID: 25172801]
[56]
Csiszar A. Anti-inflammatory effects of resveratrol: Possible role in prevention of age-related cardiovascular disease. Ann N Y Acad Sci 2011; 1215(1): 117-22.
[http://dx.doi.org/10.1111/j.1749-6632.2010.05848.x] [PMID: 21261649]
[57]
Semwal DK, Kumar A, Aswal S, Chauhan A, Semwal RB. Protective and therapeutic effects of natural products against diabetes mellitus via regenerating pancreatic β-cells and restoring their dysfunction. Phytother Res 2021; 35(3): 1218-29.
[http://dx.doi.org/10.1002/ptr.6885] [PMID: 32987447]

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