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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Perspective

Endocrine Disruptors and Obesity: An Overview

Author(s): Isanna Murro, Giuseppe Lisco, Carmen Di Noia, Luisa Lampignano, Roberta Zupo, Vito Angelo Giagulli, Edoardo Guastamacchia, Vincenzo Triggiani and Giovanni De Pergola*

Volume 22, Issue 8, 2022

Published on: 12 May, 2022

Page: [798 - 806] Pages: 9

DOI: 10.2174/1871530322666220328122300

Abstract

Obesity is a growing pandemic. Endocrine-disrupting chemicals are widespread in the environment. In this perspective, the authors examine the issue related to the exposure to several chemicals with endocrine-disrupting properties as promoting factors to obesity. Data show that Phthalates, Bisphenol compounds, Persistent Organic Pollutants (POPs), solvents, and personal care products can modify metabolic properties in a dose-response and sex-specific manner. Phthalates and bisphenol compounds increase body mass index, waist circumference, waist to height ratio, and the sum of skinfold thicknesses in women and not in men. Low-dose exposure to Persistent Organic Pollutants is strongly associated with increased body mass index in men and decreased this parameter in women. The mechanism through which these compounds act on anthropometric parameters is not entirely understood. Several studies suggest a possible interference in gonadotropin secretion and the thyroid axis. These inspire a decrease in both total and free testosterone levels in men and FT3 and FT4 levels in women, particularly after a pregnancy. The impact of endocrine disruptor chemicals on adipose tissue inflammation and future cardio-metabolic disorders remains to be elucidated. Therefore, studies involving both healthy and obese individuals are needed to unambiguously confirm results from in vitro and animal models.

Keywords: Endocrine-disrupting chemicals, obesity, adipose tissue, phthalates, bisphenols, persistent organic pollutants.

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Graphical Abstract

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