Login Register Cart 0
Generic placeholder image

Recent Advances in Inflammation & Allergy Drug Discovery

Editor-in-Chief

ISSN (Print): 2772-2708
ISSN (Online): 2772-2716

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Research Article

Major Histocompatibility Complex Class II HLA-DRB1 Allelic Epitopes in Fibromyalgia

Author(s): Basant K. Puri*, Gary S. Lee and Armin Schwarzbach

Volume 16, Issue 1, 2022

Published on: 21 March, 2022

Page: [16 - 18] Pages: 3

DOI: 10.2174/2772270816666220321162802

Price: $65

conference banner
Abstract

Background: Preliminary evidence has pointed an association of the gene HLA-DRB1 with fibromyalgia. HLA-DRB1 alleles carrying the shared or susceptibility epitope encoding the five-amino acid motif QKRAA, QRRAA or RRRAA in positions 70 to 74 of the major histocompatibility complex class II DRβ chain are associated with several autoimmune diseases.

Objective: The objective of this study was to test the hypothesis that susceptibility epitope-encoding HLA-DRB1 alleles are associated with fibromyalgia.

Methods: Using a case-control design, the prevalence of susceptibility epitope-encoding HLADRB1 alleles in 27 white Caucasian patients fulfilling the revised diagnostic criteria for fibromyalgia of the American College of Rheumatology was compared with that in 27 white Caucasian ageand sex-matched healthy controls.

Results: 13 (48%) of the fibromyalgia patients had susceptibility epitope-coding HLA-DRB1 alleles compared with 15 (56%) of the controls (P = 0.785). The DRB1*01 allele encoding the protective epitope 70-DERAA-74 motif was found in one of the control subjects; none of the fibromyalgia patients had such a protective epitope.

Conclusion: While the present study does not provide evidence supporting the potential role of HLA-DRB1 in the etiology of fibromyalgia, it does not exclude the possibility that there is a polygenic component to a putative genetic causative role.

Keywords: Autoimmune disease, fibromyalgia, human leukocyte antigen, inflammation, major histocompatibility complex, protective epitope, rheumatoid arthritis, susceptibility epitope.

« Previous Next »
Graphical Abstract

[1]
Janssen LP, Medeiros LF, Souza A, Silva JD. Fibromyalgia: A review of related polymorphisms and clinical relevance. An Acad Bras Cienc 2021; 93 (Suppl. 4): e20210618.
[http://dx.doi.org/10.1590/0001-3765202120210618] [PMID: 34730627]
[2]
Banfi G, Diani M, Pigatto PD, Reali E. T cell subpopulations in the physiopathology of fibromyalgia: Evidence and perspectives. Int J Mol Sci 2020; 21(4): E1186.
[http://dx.doi.org/10.3390/ijms21041186] [PMID: 32054062]
[3]
Burda CD, Cox FR, Osborne P. Histocompatability antigens in the fibrositis (fibromyalgia) syndrome. Clin Exp Rheumatol 1986; 4(4): 355-8.
[PMID: 3491715]
[4]
Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol 1999; 26(2): 408-12.
[PMID: 9972977]
[5]
Silver J, Goyert SM. Epitopes are the functional units of HLA class II molecules and form the molecular basis for disease susceptibility HLA Class II Antigens: A comprehensive review of structure and function. Berlin, Heidelberg: Springer 1986; pp. 32-48.
[http://dx.doi.org/10.1007/978-3-642-70367-6_3]
[6]
Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis. An approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987; 30(11): 1205-13.
[http://dx.doi.org/10.1002/art.1780301102] [PMID: 2446635]
[7]
Haworth S, Ridgeway J, Stewart I, Dyer PA, Pepper L, Ollier W. Polymyalgia rheumatica is associated with both HLA-DRB1*0401 and DRB1*0404. Br J Rheumatol 1996; 35(7): 632-5.
[http://dx.doi.org/10.1093/rheumatology/35.7.632] [PMID: 8670595]
[8]
Mathias K, Amarnani A, Pal N, et al. Chronic pain in patients with rheumatoid arthritis. Curr Pain Headache Rep 2021; 25(9): 59.
[http://dx.doi.org/10.1007/s11916-021-00973-0] [PMID: 34269913]
[9]
Giacomelli C, Talarico R, Bombardieri S, Bazzichi L. The interaction between autoimmune diseases and fibromyalgia: Risk, disease course and management. Expert Rev Clin Immunol 2013; 9(11): 1069-76.
[http://dx.doi.org/10.1586/1744666X.2013.849440] [PMID: 24168413]
[10]
Wolfe F, Clauw DJ, Fitzcharles M-A, et al. The American college of rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res (Hoboken) 2010; 62(5): 600-10.
[http://dx.doi.org/10.1002/acr.20140] [PMID: 20461783]
[11]
R Core Team. R: A Language and Environment for Statistical Computing. Vienna, Austria: R Foundation for Statistical Computing 2021.
[12]
JASP Team. JASP (Version 015). University of Amsterdam 2021.
[13]
Gerra MC, González-Villar A, Arendt-Nielsen L, et al. A family-based study to identify genetic biomarkers of fibromyalgia: Consideration of patients’ subgroups. Clin Exp Rheumatol 2021; 130(3): 144-52.
[14]
Ellerbrock I, Sandström A, Tour J, et al. Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls. Mol Brain 2021; 14(1): 81.
[http://dx.doi.org/10.1186/s13041-021-00789-4] [PMID: 33980291]
[15]
Estévez-López F, Guerrero-González JM, Salazar-Tortosa D, et al. Interplay between genetics and lifestyle on pain susceptibility in women with fibromyalgia: The al-Ándalus project. Rheumatology (Oxford) 2021; 2021: keab911.
[http://dx.doi.org/10.1093/rheumatology/keab911] [PMID: 34875034]

Rights & Permissions Print Cite
Article Metrics
4
© 2024 Bentham Science Publishers | Privacy Policy