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Review Article

假马齿苋对帕金森病的临床前循证神经保护潜力的综合评价

卷 23, 期 9, 2022

发表于: 26 April, 2022

页: [889 - 901] 页: 13

弟呕挨: 10.2174/1389450123666220316091734

价格: $65

摘要

帕金森病是一种慢性和逐渐进行性的神经退行性疾病，由于黑质致密部区域中多巴胺释放神经元的丧失而引发，其特征是运动症状，如震颤、运动迟缓、运动不能和姿势不稳。蛋白质病、线粒体功能障碍引起的多巴胺能神经元退化和基因突变是帕金森病的标志。 Brahmi 的生物活性成分，如 Bacoside A、Bacoside B 和 Bacosaponins，属于各种化学家族。 Brahmi 的神经保护作用包括减少神经元氧化应激、多巴胺能神经元变性、线粒体功能障碍、炎症、抑制 α-突触核蛋白聚集以及改善认知和学习行为。研究人员发现，假马齿苋显着增加暴露于香烟烟雾的大鼠大脑中谷胱甘肽、维生素 C、维生素 E 和维生素 A 的水平。 Brahmi 具有强大的抗氧化特性和对 PD 的神经保护作用，有助于减少氧化应激和神经炎症并提高多巴胺水平。该综述整理了所有证明 Brahmi 对治疗 PD 具有有益神经保护作用的临床前研究。

关键词: Brahmi，神经保护，帕金森氏症，多巴胺，抗氧化剂，抗炎。

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