Radiotherapy and Breast Reconstruction: What Is the Ideal Timing?
A Narrative Review

Evanthia      Letsiou; Sergios      Tsakatikas; George      Vakis; Konstantinos      Tsapakidis; Nikolaos      Charalampakis; Alexandros      Diamantis; Antigoni      Poultsidi; Dimosthenis      Michelakis; Eelco      de Bree; Davide      Mauri; Nikolaos      Tsoukalas; Chrysostomos      Antoniades; Maria      Tolia
doi:10.2174/1574887117666220314161609
Abstract

Introduction: Women undergoing mastectomy choose to pursue breast reconstruction (BR) in order to reduce their body image distress.Adjuvant chest wall irradiation is associated with a negative cosmetic outcome. The aim of our review was to identify the optimal timing of BR relating to radiotherapy delivery.
Materials and Methods: Using Cochrane Library, Embase, PubMed, Springer, Wanfang and CNKI, we performed a non-systematic review of articles published up to August 2021.
Results: There is no hard evidence in favor of immediate, delayed or 2-stage BR when post-mastectomy radiation is indicated. Immediate and 2-stage BR seem to be valid alternatives to delayed BR.
Conclusions: Further research is essential in order to assess clinician and patient reported aesthetic outcomes and determine the optimal timing of BR in view of post-mastectomy radiotherapy, in breast cancer survivors.
Keywords: Breast, cancer, breast reconstruction, radiotherapy, timing, review.
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DOI https://dx.doi.org/10.2174/1574887117666220314161609	Print ISSN 1574-8871
Publisher Name Bentham Science Publisher	Online ISSN 1876-1038
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