Abstract
Magnetic resonance spectroscopy (MRS) has been used for several decades to examine the biochemistry of the myocardium in a non destructive manner. 31P MRS, in particular, has been used to study heart failure. 31P MRS allows for the detection of adenosine triphosphate (ATP), the primary energy source for all energy consuming processes in cardiomyocytes, and phosphocreatine (PCr). Via the creatine kinase (CK) reaction PCr forms the primary ATP buffer in the cell and is involved in transporting the chemical energy from the ATP-producing mitochondria to the ATP-consuming contractile proteins. MRS examination of the failing heart has revealed that PCr, and to a lesser extent, ATP is reduced. These findings have led to the concept that the heart is energy starved. The additional application of 1H MRS has allowed for the detection of total creatine, allowing for in depth examination of the creatine kinase system. Using saturation transfer techniques it is also possible to measure flux through the CK reaction in the intact heart, and the application of this technique has proven that in the failing human heart this flux is reduced. In recent years the study of transgenic animal models by MRS has led to further insights into the role of energy metabolism in heart failure.
Current Pharmaceutical Design
Title: The Application of NMR Spectroscopy for the Study of Heart Failure
Volume: 14 Issue: 18
Author(s): Michiel ten Hove and Stefan Neubauer
Affiliation:
Abstract: Magnetic resonance spectroscopy (MRS) has been used for several decades to examine the biochemistry of the myocardium in a non destructive manner. 31P MRS, in particular, has been used to study heart failure. 31P MRS allows for the detection of adenosine triphosphate (ATP), the primary energy source for all energy consuming processes in cardiomyocytes, and phosphocreatine (PCr). Via the creatine kinase (CK) reaction PCr forms the primary ATP buffer in the cell and is involved in transporting the chemical energy from the ATP-producing mitochondria to the ATP-consuming contractile proteins. MRS examination of the failing heart has revealed that PCr, and to a lesser extent, ATP is reduced. These findings have led to the concept that the heart is energy starved. The additional application of 1H MRS has allowed for the detection of total creatine, allowing for in depth examination of the creatine kinase system. Using saturation transfer techniques it is also possible to measure flux through the CK reaction in the intact heart, and the application of this technique has proven that in the failing human heart this flux is reduced. In recent years the study of transgenic animal models by MRS has led to further insights into the role of energy metabolism in heart failure.
Export Options
About this article
Cite this article as:
Hove ten Michiel and Neubauer Stefan, The Application of NMR Spectroscopy for the Study of Heart Failure, Current Pharmaceutical Design 2008; 14 (18) . https://dx.doi.org/10.2174/138161208784746743
DOI https://dx.doi.org/10.2174/138161208784746743 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Editorial: The Interplay between TSH and Lipids. What Should Clinicians Know?
Current Vascular Pharmacology MicroRNAs in the Diagnosis and Treatment of Unstable Angina
Current Topics in Medicinal Chemistry The Adenine Nucleotide Translocase 2, a Mitochondrial Target for Anticancer Biotherapy
Current Drug Targets Inflammatory Biomarkers and Cardiovascular Risk Assessment. Current Knowledge and Future Perspectives
Current Pharmaceutical Design Peroxynitrite-Driven Mechanisms in Diabetes and Insulin Resistance – the Latest Advances
Current Medicinal Chemistry In silico Prediction of Drug Metabolism by P450
Current Drug Metabolism Ghrelin in Hypothalamic Regulation of Energy Balance
Current Topics in Medicinal Chemistry Nephrotoxicity Associated with Antiretroviral Therapy in HIV-Infected Patients
Current Drug Safety Chondroitin Sulfate and Sulfur Containing Chondroprotective Agents: Is there a Basis for their Pharmacological Action?
Current Rheumatology Reviews Emergence of Azole Therapy for Cancer Associated Fungal Infections and Their Potential Human Toxicity
The Natural Products Journal Neuro-Inflammatory Mechanisms in Developmental Disorders Associated with Intellectual Disability and Autism Spectrum Disorder: A Neuro- Immune Perspective
CNS & Neurological Disorders - Drug Targets Endothelin Receptors in Gastrointestinal Smooth Muscle
Current Protein & Peptide Science Challenges and Solutions in the Development of Genomic Biomarker Panels: A Systematic Phased Approach
Current Genomics Enantiomeric Local Anesthetics: Can Ropivacaine and Levobupivacaine Improve Our Practice?
Current Drug Therapy Preparation, Characterization, and In Vitro Release of Vinorelbine Tartrate (VLBT)- Loaded Folate-conjugated Recombination Human Serum Albumin (rHSA) Nanoparticles with Different Degree of Cross-linking
Current Nanoscience A Review of the Ethnopharmacology, Phytochemistry and Pharmacology of Plants of the Maytenus Genus
Current Pharmaceutical Design Radioligands for the Angiotensin II Subtype 1 (AT1) Receptor
Current Topics in Medicinal Chemistry The Role of Coagulation and Fibrinolysis in the Pathogenesis of Acute Lung Injury
Current Respiratory Medicine Reviews Reprogrammed Metabolism of Cancer Cells as a Potential Therapeutic Target
Current Pharmaceutical Design <i>In silico</i>-based Approach to Investigate the Ability of PEGylated Rapamycin to Inhibit Galectin-3
Current Drug Discovery Technologies