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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Research Article

An Insight into the Role of E2F1 in Breast Cancer Progression, Drug Resistance, and Metastasis

Author(s): Zafar Abbas Shah, Faisal Nouroz, Samina Ejaz* and Asima Tayyeb

Volume 23, Issue 4, 2023

Published on: 01 August, 2022

Page: [365 - 376] Pages: 12

DOI: 10.2174/1566524022666220308095834

Price: $65

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Abstract

Aims: This study aimed to investigate the role of E2F1 in breast cancer biology.

Background: Expression of E2F1, a transcription factor of many oncogenes and tumor suppressor genes, is lowered in several malignancies, including breast carcinoma.

Objectives: In the present study, we analyzed the status of E2F1 expression in association with diverse attributes of breast malignancy and its impact on cancer progression.

Methods: For this purpose, we used various freely available online applications for gene enrichment, expression, and methylation analysis to extract mutation-based E2F1 map, to measure E2F1 drug sensitivity, and to determine E2F1 association with DNA damage response proteins.

Results: Results revealed tissue-specific regulatory behavior of E2F1. Moreover, the key role of E2F1 in the promotion of metastasis, stem cell-mediated carcinogenesis, estrogen-mediated cell proliferation, and cellular defense system, has therefore highlighted it as a metaplastic marker and hot member of key resistome pathways.

Conclusion: The information thus generated can be employed for future implications in devising rational therapeutic strategies. Moreover, this study has provided a more detailed insight into the diagnostic and prognostic potential of E2F1.

Keywords: Breast Invasive Carcinoma (BRIC), Triple Negative Breast Carcinoma (TNBC), cellular proliferation, estrogen pathways, cyclin-dependent kinases (CDKs), biomarker.

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