Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Abstract

Background: COVID-19 pandemic information is critical to study it further, but the virus has still not been confined. In addition, even if there is no longer any threat, more knowledge may be gathered from these resources.

Methods: The data used in this study was gathered from several scientific areas and the links between them. Since the COVID-19 pandemic has not been fully contained, and additional information can be gleaned from these references, bibliometric analysis of it is important

Results: A total of 155 publications on the topic of "COVID-19" and the keyword "nanotechnology" was identified in the Scopus database between 2020 and 2021 in a network visualization map.

Conclusion: As a result, our analysis was conducted appropriately to provide a comprehensive understanding of COVID-19 and nanotechnology and prospective research directions for medicinal chemistry.

Keywords: COVID-19, Bibliometric data, nanotechnology, medicinal chemistry, drug delivery, target.

Next »
Graphical Abstract

[1]
Weiss, C.; Carriere, M.; Fusco, L.; Capua, I.; Regla-Nava, J.A.; Pasquali, M.; Scott, J.A.; Vitale, F.; Unal, M.A.; Mattevi, C.; Bedognetti, D.; Merkoçi, A.; Tasciotti, E.; Yilmazer, A.; Gogotsi, Y.; Stellacci, F.; Delogu, L.G. Toward nanotechnology-enabled approaches against the COVID-19 pandemic. ACS Nano, 2020, 14(6), 6383-6406.
[http://dx.doi.org/10.1021/acsnano.0c03697] [PMID: 32519842]
[2]
Shin, M.D.; Shukla, S.; Chung, Y.H.; Beiss, V.; Chan, S.K.; Ortega-Rivera, O.A.; Wirth, D.M.; Chen, A.; Sack, M.; Pokorski, J.K.; Steinmetz, N.F. COVID-19 vaccine development and a potential nanomaterial path forward. Nat. Nanotechnol., 2020, 15(8), 646-655.
[http://dx.doi.org/10.1038/s41565-020-0737-y] [PMID: 32669664]
[3]
Asif, M.; Xu, Y.; Xiao, F.; Sun, Y. Diagnosis of COVID-19, vitality of emerging technologies and preventive measures. Chem. Eng. J., 2021, 423, 130189.
[http://dx.doi.org/10.1016/j.cej.2021.130189] [PMID: 33994842]
[4]
Bhalla, N.; Pan, Y.; Yang, Z.; Payam, A.F. Opportunities and challenges for biosensors and nanoscale analytical tools for pandemics: COVID-19. ACS Nano, 2020, 14(7), 7783-7807.
[http://dx.doi.org/10.1021/acsnano.0c04421] [PMID: 32551559]
[5]
Kalantar-Zadeh, K.; Ward, S.A.; Kalantar-Zadeh, K.; El-Omar, E.M. Considering the effects of microbiome and diet on SARS-CoV-2 infection: Nanotechnology roles. ACS Nano, 2020, 14(5), 5179-5182.
[http://dx.doi.org/10.1021/acsnano.0c03402] [PMID: 32356654]
[6]
Chung, Y.H.; Beiss, V.; Fiering, S.N.; Steinmetz, N.F. COVID-19 Vaccine frontrunners and their nanotechnology design. ACS Nano, 2020, 14(10), 12522-12537.
[http://dx.doi.org/10.1021/acsnano.0c07197] [PMID: 33034449]
[7]
Chan, W.C.W. Nano research for COVID-19. ACS Nano, 2020, 14(4), 3719-3720.
[http://dx.doi.org/10.1021/acsnano.0c02540] [PMID: 32227916]
[8]
Talebian, S.; Wallace, G.G.; Schroeder, A.; Stellacci, F.; Conde, J. Nanotechnology-based disinfectants and sensors for SARS-CoV-2. Nat. Nanotechnol., 2020, 15(8), 618-621.
[http://dx.doi.org/10.1038/s41565-020-0751-0] [PMID: 32728083]
[9]
Chauhan, D.S.; Prasad, R.; Srivastava, R.; Jaggi, M.; Chauhan, S.C.; Yallapu, M.M. Comprehensive review on current interventions, diagnostics, and nanotechnology perspectives against SARS-CoV-2. Bioconjug. Chem., 2020, 31(9), 2021-2045.
[http://dx.doi.org/10.1021/acs.bioconjchem.0c00323] [PMID: 32680422]
[10]
Ruiz-Hitzky, E.; Darder, M.; Wicklein, B.; Ruiz-Garcia, C.; Martín-Sampedro, R.; Del Real, G.; Aranda, P. Nanotechnology responses to COVID-19. Adv. Healthc. Mater., 2020, 9(19), e2000979.
[http://dx.doi.org/10.1002/adhm.202000979] [PMID: 32885616]
[11]
Rabiee, N.; Rabiee, M.; Bagherzadeh, M.; Rezaei, N. COVID-19 and picotechnology: Potential opportunities. Med. Hypotheses, 2020, 144, 109917.
[http://dx.doi.org/10.1016/j.mehy.2020.109917] [PMID: 32505072]
[12]
Lukas, H.; Xu, C.; Yu, Y.; Gao, W. Emerging telemedicine tools for remote COVID-19 diagnosis, monitoring, and management. ACS Nano, 2020, 14(12), 16180-16193.
[http://dx.doi.org/10.1021/acsnano.0c08494] [PMID: 33314910]
[13]
Zyoud, S.H.; Zyoud, A.H. Coronavirus disease-19 in environmental fields: A bibliometric and visualization mapping analysis. Environ. Dev. Sustain., 2020, 6, 1-29.
[PMID: 33041643]
[14]
Vaksevanidis, M.N.; Vencl, A.; Asenova, E.; Kandeva, M.; Psilaki, P. Scientific literature on thermal spray coatings from Southeastern Europe: A ten years bibliometric analysis. FME Transactions., 2019, 47(3), 649-657.
[http://dx.doi.org/10.5937/fmet1903649V]
[15]
van Eck, N.J.; Waltman, L. Software survey: VOSviewer, a computer program for bibliometric mapping. Scientometrics, 2010, 84(2), 523-538.
[http://dx.doi.org/10.1007/s11192-009-0146-3] [PMID: 20585380]
[16]
Zhao, Y. Special issue “new studies of conjugated compounds”. Molecules, 2020, 25(14), 3220.
[http://dx.doi.org/10.3390/molecules25143220] [PMID: 32679658]
[17]
Bhavana, V.; Thakor, P.; Singh, S.B.; Mehra, N.K. COVID-19: Pathophysiology, treatment options, nanotechnology approaches, and research agenda to combating the SARS-CoV2 pandemic. Life Sci., 2020, 261, 118336.
[http://dx.doi.org/10.1016/j.lfs.2020.118336] [PMID: 32846164]
[18]
de Sousa, F.D.B. Management of plastic waste: A bibliometric mapping and analysis. Waste Manag. Res., 2021, 39(5), 664-678.
[http://dx.doi.org/10.1177/0734242X21992422] [PMID: 33624576]
[19]
Hassan, N.R.; Loebbecke, C. Engaging scientometrics in in- formation systems. J. Inf. Technol., 2017, 32(1), 85-109.
[http://dx.doi.org/10.1057/jit.2015.29]
[20]
Losse, M.; Geissdoerfer, M. Mapping socially responsible investing: A bibliometric and citation network analysis. J. Clean. Prod., 2021, 296(4), 126376.
[http://dx.doi.org/10.1016/j.jclepro.2021.126376]
[21]
Muñoz-Écija, T.; Vargas-Quesada, B.; Chinchilla-Rodríguez, Z. Identification and visualization of the intellectual structure and the main research lines in nanoscience and nanotechnology at the worldwide level. J. Nanopart. Res., 2017, 19(2), 62-62.
[http://dx.doi.org/10.1007/s11051-016-3732-3] [PMID: 28250713]
[22]
van Eck, N.J.; Waltman, L.; Dekker, R.; van den Berg, J. A comparison of two techniques for bibliometric mapping: Multidimensional scaling and VOS. J. Am. Soc. Inf. Sci. Technol., 2010, 61(12), 2405-2416.
[http://dx.doi.org/10.1002/asi.21421]
[23]
Darsono, D.; Rohmana, J.A.; Busro, B. Against COVID-19 Pandemic: Bibliometric assessment of world scholars’ international publications related to COVID-19. Jurnal Komunikasi Ikatan Sarjana Komunikasi Indonesia., 2020, 5(1), 75-89.
[http://dx.doi.org/10.25008/jkiski.v5i1.356]
[24]
Galvez, C. Evolution of the field of social media research through science maps (2008-2017). Commun. Soc., 2019, 32(2), 61-76.
[http://dx.doi.org/10.15581/003.32.2.61-76]
[25]
Aristovnik, A.; Ravšelj, D.; Umek, L. A bibliometric analysis of COVID-19 across science and social science research landscape. Sustainability (Basel), 2020, 12(21), 9132.
[http://dx.doi.org/10.3390/su12219132]
[26]
Geraghty, R.J.; Aliota, M.T.; Bonnac, L.F. Broad-spectrum antiviral strategies and nucleoside analogues. Viruses, 2021, 13(4), 667.
[http://dx.doi.org/10.3390/v13040667] [PMID: 33924302]
[27]
Ma, Y.; Frutos-Beltrán, E.; Kang, D.; Pannecouque, C.; De Clercq, E.; Menéndez-Arias, L.; Liu, X.; Zhan, P. Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses. Chem. Soc. Rev., 2021, 50(7), 4514-4540.
[http://dx.doi.org/10.1039/D0CS01084G] [PMID: 33595031]
[28]
Chauhan, G.; Madou, M.J.; Kalra, S.; Chopra, V.; Ghosh, D.; Martinez-Chapa, S.O. Nanotechnology for COVID-19: Therapeutics and vaccine research. ACS Nano, 2020, 14(7), 7760-7782.
[http://dx.doi.org/10.1021/acsnano.0c04006] [PMID: 32571007]
[29]
Jones, G.W.; Monopoli, M.P.; Campagnolo, L.; Pietroiusti, A.; Tran, L.; Fadeel, B. No small matter: a perspective on nanotechnology-enabled solutions to fight COVID-19. Nanomedicine (Lond.), 2020, 15(24), 2411-2427.
[http://dx.doi.org/10.2217/nnm-2020-0286] [PMID: 32873192]
[30]
Diag Liu, Y.; Ye, H.; Huynh, H.; Kang, P.; Xie, C.; Kahn, J.S.; Qin, Z. Single-particle counting based on digital plasmonic nanobubble detection for rapid and ultrasensitive diagnostics. medRxiv, 2021. preprint.
[31]
Reina, G.; Peng, S.; Jacquemin, L.; Andrade, A.F.; Bianco, A. Hard nanomaterials in time of viral pandemics. ACS Nano, 2020, 14(8), 9364-9388.
[http://dx.doi.org/10.1021/acsnano.0c04117] [PMID: 32667191]
[32]
Rabiee, N.; Bagherzadeh, M.; Ghasemi, A.; Zare, H.; Ahmadi, S.; Fatahi, Y.; Dinarvand, R.; Rabiee, M.; Ramakrishna, S.; Shokouhimehr, M.; Varma, R.S. Point-of-use rapid detection of SARS-CoV-2: Nanotechnology-enabled solutions for the COVID-19 pandemic. Int. J. Mol. Sci., 2020, 21(14), 5126.
[http://dx.doi.org/10.3390/ijms21145126] [PMID: 32698479]
[33]
Nikaeen, G.; Abbaszadeh, S.; Yousefinejad, S. Application of nanomaterials in treatment, anti-infection and detection of coronaviruses. Nanomedicine (Lond.), 2020, 15(15), 1501-1512.
[http://dx.doi.org/10.2217/nnm-2020-0117] [PMID: 32378459]
[34]
Jackson, L.A.; Anderson, E.J.; Rouphael, N.G.; Roberts, P.C.; Makhene, M.; Coler, R.N.; McCullough, M.P.; Chappell, J.D.; Denison, M.R.; Stevens, L.J.; Pruijssers, A.J.; McDermott, A.; Flach, B.; Doria-Rose, N.A.; Corbett, K.S.; Morabito, K.M.; O’Dell, S.; Schmidt, S.D.; Swanson, P.A., II; Padilla, M.; Mascola, J.R.; Neuzil, K.M.; Bennett, H.; Sun, W.; Peters, E.; Makowski, M.; Albert, J.; Cross, K.; Buchanan, W.; Pikaart-Tautges, R.; Ledgerwood, J.E.; Graham, B.S.; Beigel, J.H. mRNA-1273 study group. An mRNA vaccine against SARS-CoV-2 - preliminary report. N. Engl. J. Med., 2020, 383(20), 1920-1931.
[http://dx.doi.org/10.1056/NEJMoa2022483] [PMID: 32663912]
[35]
Lee, W.S.; Wheatley, A.K.; Kent, S.J.; DeKosky, B.J. Antibody-dependent enhancement and SARS-CoV-2 vaccines and therapies. Nat. Microbiol., 2020, 5(10), 1185-1191.
[http://dx.doi.org/10.1038/s41564-020-00789-5] [PMID: 32908214]
[36]
Zahid, M.N.; Moosa, M.S.; Perna, S.; Buti, E.B. A review on COVID-19 vaccines: stages of clinical trials, mode of actions and efficacy. Arab. J. Basic App. Sci., 2021, 28(1), 225-233.
[http://dx.doi.org/10.1080/25765299.2021.1903144]
[37]
Kumar, A.; Dowling, W.E.; Román, R.G.; Chaudhari, A.; Gurry, C.; Le, T.T.; Tollefson, S.; Clark, C.E.; Bernasconi, V.; Kristiansen, P.A. Status report on COVID-19 vaccines development. Curr. Infect. Dis. Rep., 2021, 23(6), 9.
[http://dx.doi.org/10.1007/s11908-021-00752-3] [PMID: 33867863]
[38]
Forni, G.; Mantovani, A. COVID-19 vaccines: where we stand and challenges ahead. Cell Death Differ., 2021, 28(2), 626-639.
[http://dx.doi.org/10.1038/s41418-020-00720-9] [PMID: 33479399]
[39]
Antiochia, R. Nanobiosensors as new diagnostic tools for SARS, MERS and COVID-19: from past to perspectives. Mikrochim. Acta, 2020, 187(12), 639.
[http://dx.doi.org/10.1007/s00604-020-04615-x] [PMID: 33151419]
[40]
Pinals, R.L.; Ledesma, F.; Yang, D.; Navarro, N.; Jeong, S.; Pak, J.E.; Kuo, L.; Chuang, Y.C.; Cheng, Y.W.; Sun, H.Y.; Landry, M.P. Rapid SARS-CoV-2 spike protein detection by carbon nanotube-based near-infrared nanosensors. Nano Lett., 2021, 21(5), 2272-2280.
[http://dx.doi.org/10.1021/acs.nanolett.1c00118] [PMID: 33635655]
[41]
Qiao, J; Qi, L Recent progress in plant-gold nanoparticles fabrication methods and bio-applications. Talanta, 2021, 223(Pt 2), 121396.
[http://dx.doi.org/10.1016/j.talanta.2020.121396]
[42]
Sharifi, M; Hasan, A; Haghighat, S; Taghizadeh, A; Attar, F; Bloukh, SH; Edis, Z; Xue, M; Khan, S; Falahati, M Rapid diagnostics of coronavirus disease 2019 in early stages using nanobiosensors: Challenges and opportunities. Talanta, 2021, 223(Pt 1), 121704.
[43]
Vermisoglou, E; Panáček, D; Jayaramulu, K; Pykal, M; Frébort, I; Kolář, M; Hajdúch, M; Zbořil, R; Otyepka, M Human virus detection with graphene-based materials. Biosens Bioelectron., 2020, 15(166), 112436.
[http://dx.doi.org/10.1016/j.bios.2020.112436]
[44]
Rahimkhoei, V.; Rezaie, J.; Akbari, A.; Nourani, A.; Jabbari, N.; Lighvan, Z.M.; Amini, M. Nano-based methods for novel coronavirus 2019 (2019-nCoV) diagnosis: A review. Cell Biochem. Funct., 2021, 39(1), 29-34.
[http://dx.doi.org/10.1002/cbf.3606] [PMID: 33319383]
[45]
Castillo-Henríquez, L.; Brenes-Acuña, M.; Castro-Rojas, A.; Cordero-Salmerón, R.; Lopretti-Correa, M.; Vega-Baudrit, J.R. Biosensors for the detection of bacterial and viral clinical pathogens. Sensors (Basel), 2020, 20(23), 6926.
[http://dx.doi.org/10.3390/s20236926] [PMID: 33291722]
[46]
Zhao, M.; Liao, L.; Xiao, W.; Yu, X.; Wang, H.; Wang, Q.; Lin, Y.L.; Kilinc-Balci, F.S.; Price, A.; Chu, L.; Chu, M.C.; Chu, S.; Cui, Y. Household materials selection for homemade cloth face coverings and their filtration efficiency enhancement with triboelectric charging. Nano Lett., 2020, 20(7), 5544-5552.
[http://dx.doi.org/10.1021/acs.nanolett.0c02211] [PMID: 32484683]
[47]
Campos, E.V.R.; Pereira, A.E.S.; de Oliveira, J.L.; Carvalho, L.B.; Guilger-Casagrande, M.; de Lima, R.; Fraceto, L.F. How can nanotechnology help to combat COVID-19? Opportunities and urgent need. J. Nanobiotechnology, 2020, 18(1), 125.
[http://dx.doi.org/10.1186/s12951-020-00685-4] [PMID: 32891146]
[48]
Zhong, H.; Zhu, Z.; Lin, J.; Cheung, C.F.; Lu, V.L.; Yan, F.; Chan, C.Y.; Li, G. Reusable and recyclable graphene masks with outstanding superhydrophobic and photothermal performances. ACS Nano, 2020, 14(5), 6213-6221.
[http://dx.doi.org/10.1021/acsnano.0c02250] [PMID: 32329600]
[49]
Palmieri, V.; Papi, M. Can graphene take part in the fight against COVID-19? Nano Today, 2020, 33, 100883.
[http://dx.doi.org/10.1016/j.nantod.2020.100883] [PMID: 32382315]
[50]
Shanmugam, A.; Muralidharan, N.; Velmurugan, D.; Gromiha, M.M. Therapeutic targets and computational approaches on drug development for COVID-19. Curr. Top. Med. Chem., 2020, 20(24), 2210-2220.
[http://dx.doi.org/10.2174/1568026620666200710105507] [PMID: 32648845]
[51]
Sabbah, D.A.; Hajjo, R.; Bardaweel, S.K.; Zhong, H.A. An updated review on betacoronavirus viral entry inhibitors: Learning from past discoveries to advance COVID-19 drug discovery. Curr. Top. Med. Chem., 2021, 21(7), 571-596.
[http://dx.doi.org/10.2174/1568026621666210119111409] [PMID: 33463470]
[52]
Lai, C.C.; Shih, T.P.; Ko, W.C.; Tang, H.J.; Hsueh, P.R. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges. Int. J. Antimicrob. Agents, 2020, 55(3), 105924.
[http://dx.doi.org/10.1016/j.ijantimicag.2020.105924] [PMID: 32081636]
[53]
Ahmed, S.; Mahtarin, R.; Islam, M.S.; Das, S.; Al Mamun, A.; Ahmed, S.S.; Ali, M.A. Remdesivir analogs against SARS-CoV-2 RNA-dependent RNA polymerase. J. Biomol. Struct. Dyn., 2021, 1-14.
[http://dx.doi.org/10.1080/07391102.2021.1955743] [PMID: 34315339]
[54]
Sharma, V.; Sharma, A.; Bharate, S.B. Natural products in mitigation of SARS CoV infections. Curr. Med. Chem., 2021, 28(22), 4454-4483.
[http://dx.doi.org/10.2174/0929867327666201027153940] [PMID: 33109028]
[55]
Hartini, Y.; Saputra, B.; Wahono, B.; Auw, Z.; Indayani, F.; Adelya, L.; Namba, G.; Hariono, M. Biflavonoid as potential 3-chymotrypsin-like protease (3CLpro) inhibitor of SARS-coronavirus. Results Chem., 2021, 3, 100087.
[http://dx.doi.org/10.1016/j.rechem.2020.100087] [PMID: 33520632]
[56]
Farzin, L.; Sadjadi, S.; Sheini, A.; Mohagheghpour, E. A nano-scale genosensor for early detection of COVID-19 by voltammetric determination of RNA-dependent RNA polymerase (RdRP) sequence of SARS-CoV-2 virus. Mikrochim. Acta, 2021, 188(4), 121.
[http://dx.doi.org/10.1007/s00604-021-04773-6] [PMID: 33694010]
[57]
Hu, C.J.; Chang, W.S.; Fang, Z.S.; Chen, Y.T.; Wang, W.L.; Tsai, H.H.; Chueh, L.L.; Takano, T.; Hohdatsu, T.; Chen, H.W. Nanoparticulate vacuolar ATPase blocker exhibits potent host-targeted antiviral activity against feline coronavirus. Sci. Rep., 2017, 7(1), 13043.
[http://dx.doi.org/10.1038/s41598-017-13316-0] [PMID: 29026122]
[58]
Abou-El-Naga, I.F.; El Kerdany, E.D.; Mady, R.F.; Shalaby, T.I.; Zaytoun, E.M. The effect of lopinavir/ritonavir and lopinavir/ritonavir loaded PLGA nanoparticles on experimental toxoplasmosis. Parasitol. Int., 2017, 66(6), 735-747.
[http://dx.doi.org/10.1016/j.parint.2017.08.007] [PMID: 28838776]
[59]
Refaat, H.; Mady, F.M.; Sarhan, H.A.; Rateb, H.S.; Alaaeldin, E. Optimization and evaluation of propolis liposomes as a promising therapeutic approach for COVID-19. Int. J. Pharm., 2021, 592, 120028.
[http://dx.doi.org/10.1016/j.ijpharm.2020.120028] [PMID: 33166584]
[60]
Cao, P.; Wu, S.; Wu, T.; Deng, Y.; Zhang, Q.; Wang, K.; Zhang, Y. The important role of polysaccharides from a traditional Chinese medicine-lung cleansing and detoxifying decoction against the COVID-19 pandemic. Carbohydr. Polym., 2020, 240, 116346.
[http://dx.doi.org/10.1016/j.carbpol.2020.116346] [PMID: 32475597]
[61]
Chen, X.; Han, W.; Wang, G.; Zhao, X. Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines. Int. J. Biol. Macromol., 2020, 164, 331-343.
[http://dx.doi.org/10.1016/j.ijbiomac.2020.07.106] [PMID: 32679328]
[62]
Otto, D.P.; de Villiers, M.M. Layer-By-Layer nanocoating of antiviral polysaccharides on surfaces to prevent coronavirus infections. Molecules, 2020, 25(15), 3415.
[http://dx.doi.org/10.3390/molecules25153415] [PMID: 32731428]
[63]
Chen, Y.; Yao, F.; Ming, K.; Wang, D.; Hu, Y.; Liu, J. Polysaccharides from traditional chinese medicines: Extraction, purification, modification, and biological activity. Molecules, 2016, 21(12), 1705.
[http://dx.doi.org/10.3390/molecules21121705] [PMID: 27983593]
[64]
Jiang, X.; Li, Z.; Young, D.J.; Liu, M.; Wu, C.; Wu, Y.L.; Loh, X.J. Toward the prevention of coronavirus infection: What role can polymers play? Mater Today Adv., 2021, 10, 100140.
[http://dx.doi.org/10.1016/j.mtadv.2021.100140] [PMID: 33778467]
[65]
Lee, C. Carrageenans as broad-spectrum microbicides: Current status and challenges. Mar. Drugs, 2020, 18(9), 435.
[http://dx.doi.org/10.3390/md18090435] [PMID: 32825645]
[66]
Souza, P.R.; de Oliveira, A.C.; Vilsinski, B.H.; Kipper, M.J.; Martins, A.F. Polysaccharide-based materials created by physical processes: From preparation to biomedical applications. Pharmaceutics, 2021, 13(5), 621.
[http://dx.doi.org/10.3390/pharmaceutics13050621] [PMID: 33925380]
[67]
Upadhyay, S.K.; Dan, S.; Girdhar, M.; Rastogi, K. Recent advancement in SARS-CoV-2 diagnosis, treatment, and vaccine formulation: A new paradigm of nanotechnology in strategic combating of COVID-19 pandemic. Curr. Pharmacol. Rep., 2021, 3(1), 1-14.
[http://dx.doi.org/10.1007/s40495-021-00250-z] [PMID: 33552875]
[68]
Chavda, V.P.; Vora, L.K.; Pandya, A.K.; Patravale, V.B. Intranasal vaccines for SARS-CoV-2: From challenges to potential in COVID-19 management. Drug Discov. Today, 2021, 26(11), 2619-2636.
[http://dx.doi.org/10.1016/j.drudis.2021.07.021] [PMID: 34332100]
[69]
Moitra, P.; Alafeef, M.; Dighe, K.; Frieman, M.B.; Pan, D. Selective naked-eye detection of SARS-CoV-2 mediated by N gene targeted antisense oligonucleotide capped plasmonic nanoparticles. ACS Nano, 2020, 14(6), 7617-7627.
[http://dx.doi.org/10.1021/acsnano.0c03822] [PMID: 32437124]
[70]
Mesias, V.S.D.; Zhu, H.; Tang, X.; Dai, X.; Guo, Y.; Liu, W.; Huang, J. Effective ACE2 peptide-nanoparticle conjugation and its binding with the SARS-Cov-2 RBD quantified by dynamic light scattering. Chem. Commun. (Camb.), 2021, 57(57), 6979-6982.
[http://dx.doi.org/10.1039/D1CC02267A] [PMID: 34190246]
[71]
Ramezani, Z.; Dayer, M.R.; Noorizadeh, S.; Thompson, M. Deactivation of SARS-CoV-2 via shielding of spike glycoprotein using carbon quantum dots: Bioinformatic perspective. COVID, 2021, 1(1), 120-129.
[http://dx.doi.org/10.3390/covid1010011]
[72]
Garg, P.; Sangam, S.; Kochhar, D.; Pahari, S.; Kar, C.; Mukherjee, M. Exploring the role of triazole functionalized heteroatom co-doped carbon quantum dots against human coronaviruses. Nano Today, 2020, 35, 101001.
[http://dx.doi.org/10.1016/j.nantod.2020.101001] [PMID: 33052202]
[73]
Pandey, A.; Nikam, A.N.; Mutalik, S.P.; Fernandes, G.; Shreya, A.B.; Padya, B.S.; Raychaudhuri, R.; Kulkarni, S.; Prassl, R.; Subramanian, S.; Korde, A.; Mutalik, S. Architectured therapeutic and diagnostic nanoplatforms for combating SARS-CoV-2: Role of inorganic, organic, and radioactive materials. ACS Biomater. Sci. Eng., 2021, 7(1), 31-54.
[http://dx.doi.org/10.1021/acsbiomaterials.0c01243] [PMID: 33371667]
[74]
El-Atab, N.; Mishra, R.B.; Hussain, M.M. Toward nanotechnology-enabled face masks against SARS-CoV-2 and pandemic respiratory diseases. Nanotechnology, 2021, 33(6), 062006.
[http://dx.doi.org/10.1088/1361-6528/ac3578] [PMID: 34727530]
[75]
El-Atab, N.; Qaiser, N.; Badghaish, H.; Shaikh, S.F.; Hussain, M.M. Flexible nanoporous template for the design and de- velopment of reusable anti-COVID-19 hydrophobic face masks. ACS Nano, 2020, 14(6), 7659-7665.
[http://dx.doi.org/10.1021/acsnano.0c03976] [PMID: 32432461]
[76]
Ali, M.A.; Hu, C.; Jahan, S.; Yuan, B.; Saleh, M.S.; Ju, E.; Gao, S.J.; Panat, R. Sensing of COVID-19 antibodies in seconds via aerosol jet nanoprinted reduced-graphene-oxide-coated 3D electrodes. Adv. Mater., 2021, 33(7), e2006647.
[http://dx.doi.org/10.1002/adma.202006647] [PMID: 33349975]
[77]
Gazzi, A.; Fusco, L.; Orecchioni, M.; Ferrari, S.; Franzoni, G.; Yan, J.S.; Rieckher, M.; Peng, G.; Lucherelli, M.A.; Vacchi, I.A.; Chau, N.D.Q.; Criado, A.; Istif, A.; Mancino, D.; Dominguez, A.; Eckert, H.; Vázquez, E.; Ros, T.D.; Nicolussi, P.; Palermo, V.; Schumacher, B.; Cuniberti, G.; Mai, Y.; Clementi, C.; Pasquali, M.; Feng, X.; Kostarelos, K.; Yilmazer, A.; Bedognetti, D.; Fadeel, B.; Prato, M.; Bianco, A.; Delogu, L.G. Graphene, other carbon nanomaterials and the immune system: Toward nanoimmunity-by-design. J. Phy. Mat., 2020, 3(3), 034009.
[http://dx.doi.org/10.1088/2515-7639/ab9317]
[78]
Jiang, Z.; Feng, B.; Xu, J.; Qing, T.; Zhang, P.; Qing, Z. Graphene biosensors for bacterial and viral pathogens. Biosens. Bioelectron., 2020, 166, 112471.
[http://dx.doi.org/10.1016/j.bios.2020.112471] [PMID: 32777726]
[79]
Cordaro, A.; Neri, G.; Sciortino, M.T.; Scala, A.; Piperno, A. Graphene-based strategies in liquid biopsy and in viral diseases diagnosis. Nanomaterials (Basel), 2020, 10(6), 1014.
[http://dx.doi.org/10.3390/nano10061014] [PMID: 32466536]

Rights & Permissions Print Cite
© 2025 Bentham Science Publishers | Privacy Policy
Request history8.2.27PHP Version288msRequest Duration28MBMemory UsageGET article/{article_id}/{param?}Route
  • warninglog[18:00:47] LOG.warning: Optional parameter $article_id declared before required parameter $request i...
  • warninglog[18:00:47] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • warninglog[18:00:47] LOG.warning: trim(): Passing null to parameter #1 ($string) of type string is deprecated ...
  • warninglog[18:00:47] LOG.warning: Function strftime() is deprecated in /home/alphaeurekaselec/public_html/stor...
  • Booting (94.96ms)time
  • Application (193ms)time
  • 1 x Application (66.99%)
    193ms
    1 x Booting (33%)
    94.96ms
    14 templates were rendered
    • articlearticle.blade.php#?blade
    • includes.article_top_bannerarticle_top_banner.blade.php#?blade
    • includes.article_referencearticle_reference.blade.php#?blade
    • export_citation_formexport_citation_form.blade.php#?blade
    • includes.article_bottom_bannerarticle_bottom_banner.blade.php#?blade
    • includes.inc_related_journalsinc_related_journals.blade.php#?blade
    • includes.inc_related_ebooksinc_related_ebooks.blade.php#?blade
    • includes.journal_rightmenujournal_rightmenu.blade.php#?blade
    • includes.journal_right_bannerjournal_right_banner.blade.php#?blade
    • layouts.appapp.blade.php#?blade
    • layouts._login_access_login_access.blade.php#?blade
    • layouts._header_header.blade.php#?blade
    • layouts._main_menu_main_menu.blade.php#?blade
    • layouts._footer_menu_footer_menu.blade.php#?blade
    uri
    GET article/{article_id}/{param?}
    middleware
    web, check_user_access
    controller
    App\Http\Controllers\ArticleController@GetArticleDetails
    namespace
    App\Http\Controllers
    where
    as
    article
    file
    app/Http/Controllers/ArticleController.php:1974-2510
    37 statements were executed, 4 of which were duplicates, 33 unique. Show only duplicated121ms
    • Connection Establishedalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 9. middleware::check_user_access:24
      • 10. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 11. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address (ip_address,visitor_agent,visitor_count, created_on,updated_on) VALUES ('309684047','',1,1739988047,1739988047) ON DUPLICATE KEY UPDATE visitor_count=visitor_count + 1, updated_on=1739988047
      1.19msalphaeurekaselec_live_10_06_2022UserAccessCheck.php#24
      Backtrace
      • 11. middleware::check_user_access:24
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • INSERT INTO visitor_ip_address_detail (ip_address,visitor_url,visitor_count, created_on,updated_on) VALUES ('309684047','/article/121413',1,1739988047,1739988047)
      240μsalphaeurekaselec_live_10_06_2022UserAccessCheck.php#27
      Backtrace
      • 11. middleware::check_user_access:27
      • 12. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 14. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 15. vendor/laravel/framework/src/Illuminate/Foundation/Http/Middleware/VerifyCsrfToken.php:88
    • (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_journal_volume_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_ebook_volume_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_issue_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_article_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_trail WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_chapter_token WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) union (select `user_id`, `to_ip`, `from_ip` from (select user_id, to_ip, from_ip FROM user_access_disease_corporate WHERE to_ip >= 309684047 ORDER BY to_ip ASC LIMIT 1) as `tjv` where `from_ip` <= 309684047) limit 1
      13.61msalphaeurekaselec_live_10_06_2022UserAccess.php#784
      Bindings
      • 0: 309684047
      • 1: 309684047
      • 2: 309684047
      • 3: 309684047
      • 4: 309684047
      • 5: 309684047
      • 6: 309684047
      • 7: 309684047
      • 8: 309684047
      • 9: 309684047
      • 10: 309684047
      • 11: 309684047
      • 12: 309684047
      • 13: 309684047
      • 14: 309684047
      • 15: 309684047
      Backtrace
      • 14. app/Models/UserAccess/UserAccess.php:784
      • 15. middleware::check_user_access:114
      • 16. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Middleware/SubstituteBindings.php:50
      • 18. vendor/laravel/framework/src/Illuminate/Pipeline/Pipeline.php:183
    • SELECT at.type_name, p.copyright, p.publisher_location,m.month,y.year, a.publish_on, a.nid article_nid,a.article_id, a.pmid, a.issue_id, a.title, a.abstract,a.podcast,a.altmetric_score,a.altmetric_url,a.kudos_url, a.page_count, a.first_page, a.elocator, a.last_page, i.publication_date, a.file_name, a.file_path, a.doi, a.is_epub,a.epub_type, a.volume_id, a.is_uploaded, a.editor_choice, a.is_epub, j.image_file_name, a.article_no, a.art_type AS article_type, a.supplementary_filename,a.html_filename,a.prc_filename,a.epub_filename, a.graph_abs_lg_filename, a.graph_abs_sm_filename, a.oa_image_lg_filename, a.oa_image_sm_filename, j.journal_banner,a.animated_abstract,a.erratum_in,a.erratum_for, (CASE WHEN a.issue_id =0 THEN j.epub_price ELSE j.price END) AS sell_price, j.epub_price, j.nid AS jour_nid, j.title AS journal_title, j.issn, j.eissn,j.journal_id, j.subtitle AS jour_subtitle, v.volume_id,v.volume_name AS volume, v.year_id, i.title AS issue, i.month_id ,i.type issue_type, j.subtitle,j.formerly_title, ac.subtitle AS epub_title,a.crossmark_enabled,a.text_mining_urls,a.license_urls,a.created, a.receivedate, a.revisedate, a.acceptdate,js.js_title FROM article a LEFT JOIN article_section ac ON a.is_epub = ac.art_sec_id LEFT JOIN journal_section js ON a.js_id = js.js_id LEFT JOIN article_type at ON a.art_type = at.art_type_id LEFT JOIN issue i ON a.issue_id = i.issue_id LEFT JOIN month m ON m.id = i.month_id LEFT JOIN volume v ON v.volume_id = a.volume_id INNER JOIN year y ON y.id = v.year_id INNER JOIN journal j ON j.journal_id = a.journal_id INNER JOIN publisher p ON p.publisher_id = j.publisher_id WHERE a.article_id=121413
      660μsalphaeurekaselec_live_10_06_2022Article.php#408
      Backtrace
      • 11. app/Models/Article.php:408
      • 12. app/Http/Controllers/ArticleController.php:2515
      • 13. app/Http/Controllers/ArticleController.php:2035
      • 14. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 15. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `journal` where `journal_id` = 38 limit 1
      1.02msalphaeurekaselec_live_10_06_2022Journal.php#64
      Bindings
      • 0: 38
      Backtrace
      • 14. app/Models/Journal.php:64
      • 15. app/Http/Controllers/ArticleController.php:2516
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=38) and sj.journal_id!=38 group by `j`.`nid`) as `aggregate_table`
      1.16msalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 16. app/Models/Subject.php:200
      • 17. app/Http/Controllers/ArticleController.php:2517
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select j.nid as journal_nid,j.flyer_link,j.title ,j.issn,j.eissn,j.keyword, j.journal_id as journal_id, j.subtitle, j.image_file_name,j.description,j.journal_insight_url,j.doi from `subject_journal` as `sj` inner join `journal` as `j` on `j`.`journal_id` = `sj`.`journal_id` where j.journal_status=1 and subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=38) and sj.journal_id!=38 group by `j`.`nid` order by `j`.`journal_id` asc limit 10 offset 0
      940μsalphaeurekaselec_live_10_06_2022Subject.php#200
      Backtrace
      • 14. app/Models/Subject.php:200
      • 15. app/Http/Controllers/ArticleController.php:2517
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select count(*) as aggregate from (select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=38) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid`) as `aggregate_table`
      1.56msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 16. app/Models/Subject.php:220
      • 17. app/Http/Controllers/ArticleController.php:2518
      • 18. app/Http/Controllers/ArticleController.php:2035
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 20. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select v.nid as volume_id,e.nid,e.title,v.issn,v.eissn,v.isbn,v.eisbn,e.ebook_id, v.image_file_name,v.file_path,v.flyer_link,v.ebook_volume_id, v.volume_name,v.doi,v.year_id,v.introduction from `subject_ebook` as `se` inner join `ebook` as `e` on `e`.`ebook_id` = `se`.`ebook_id` inner join `ebook_volume` as `v` on `v`.`ebook_id` = `se`.`ebook_id` inner join `year` as `y` on `y`.`id` = `v`.`year_id` where subject_id IN (SELECT subject_id FROM subject_journal WHERE journal_id=38) and v.ebook_status='1' and y.year > 2020 group by `v`.`nid` order by `v`.`ebook_volume_id` desc limit 10 offset 0
      1.43msalphaeurekaselec_live_10_06_2022Subject.php#220
      Backtrace
      • 14. app/Models/Subject.php:220
      • 15. app/Http/Controllers/ArticleController.php:2518
      • 16. app/Http/Controllers/ArticleController.php:2035
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `keywords` where `article_id` = '121413'
      1.29msalphaeurekaselec_live_10_06_2022Keywords.php#43
      Bindings
      • 0: 121413
      Backtrace
      • 13. app/Models/Keywords.php:43
      • 14. app/Http/Controllers/ArticleController.php:2519
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select * from `article_citation` where `article_id` = '121413'
      6.03msalphaeurekaselec_live_10_06_2022Article.php#1570
      Bindings
      • 0: 121413
      Backtrace
      • 13. app/Models/Article.php:1570
      • 14. app/Http/Controllers/ArticleController.php:2520
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select CONCAT_WS(' ',au.first_name, ' ', ifnull(au.initials,''), ' ', au.last_name) as authors, CONCAT(au.last_name, IFNULL(CONCAT(' ', au.initials), ''), ' ', au.first_name) AS authorsRIS, CONCAT_WS(' ',au.last_name, ' ', ifnull(au.initials,''), ' ', au.first_name) as authorsCiteAs, CONCAT_WS(' ',au.first_name, IFNULL(CONCAT(' ', au.initials), ''), IFNULL(CONCAT(' ', au.last_name), '')) as authorsmodal , `au`.*, `af`.`ror_id`, `af`.`institution`, `af`.`department`, `af`.`country`, `af`.`city`, `af`.`address`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.institution,','),''), ifnull(concat(af.department,','),''), ifnull(concat(af.address,','),''), ifnull(concat(af.city,','),''), ifnull(concat(af.country,','),''), ifnull(concat(af.postal_code,','),''), ifnull(concat(af.phone,','),''), ifnull(concat(af.fax,','),''))) SEPARATOR '|')) as `author_affiliation`, (GROUP_CONCAT(TRIM(BOTH ', ' FROM CONCAT(ifnull(concat(af.web_view,','),''))) SEPARATOR '|')) as `web_view` from `author` as `au` left join `author_affiliation` as `af` on `au`.`author_id` = `af`.`author_id` where `au`.`article_id` = '121413' group by `au`.`author_id` order by `au`.`article_id` asc, `au`.`sequence` asc
      920μsalphaeurekaselec_live_10_06_2022Author.php#86
      Bindings
      • 0: 121413
      Backtrace
      • 13. app/Models/Author.php:86
      • 14. app/Http/Controllers/ArticleController.php:2533
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      210μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2535
      • 15. app/Http/Controllers/ArticleController.php:2035
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
    • select `subtitle` from `journal` where `continues_publication_journal` = 1
      440μsalphaeurekaselec_live_10_06_2022Article.php#1960
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/Article.php:1960
      • 14. app/Http/Controllers/ArticleController.php:2062
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • Select j.subtitle, v.volume_id as volume_id,v.year_id,y.year as year,v.volume_name, v.total_no_of_issues, i.issue_id as issue_id,i.title as issue, i.publication_date as issue_pub_date from journal j join volume v on j.journal_id = v.journal_id join issue i on v.volume_id = i.volume_id join article a on a.issue_id = i.issue_id join year y on v.year_id = y.id where j.journal_id = 38 and i.is_uploaded = 1 order by v.volume_name+0 desc, i.title+0 desc limit 1
      29.67msalphaeurekaselec_live_10_06_2022Issue.php#298
      Backtrace
      • 11. app/Models/Issue.php:298
      • 12. app/Http/Controllers/ArticleController.php:2068
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 1 and a.journal_id = 38 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      18.63msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2070
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid,a.publish_on, a.pmid,a.article_id,a.doi,j.journal_id,j.subtitle,v.volume_name,a.volume_id as volume_id, a.issue_id,a.title,first_page, last_page, page_count,abstract,ifnull(is_abstract,"y"),asec.title as article_section,at.type_name as article_type_name, a.article_id as ArticleID ,is_epub,epub_price,epub_type,a.created, y.year from `article` as `a` left join `article_section` as `asec` on `asec`.`art_sec_id` = `a`.`is_epub` left join `article_type` as `at` on `at`.`art_type_id` = `a`.`art_type` left join `journal` as `j` on `j`.`journal_id` = `a`.`journal_id` inner join `volume` as `v` on `a`.`volume_id` = `v`.`volume_id` inner join `year` as `y` on `v`.`year_id` = `y`.`id` where a.article_status != "W" and a.is_epub = 4 and a.journal_id = 38 and a.is_uploaded = 1 group by `a`.`article_id` order by `a`.`publish_on` desc
      17.93msalphaeurekaselec_live_10_06_2022Article.php#528
      Backtrace
      • 13. app/Models/Article.php:528
      • 14. app/Http/Controllers/ArticleController.php:2071
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select pdf, html, epub, prc from `article_metrics` where `article_id` = 121413 limit 1
      300μsalphaeurekaselec_live_10_06_2022Article.php#744
      Bindings
      • 0: 121413
      Backtrace
      • 14. app/Models/Article.php:744
      • 15. app/Http/Controllers/ArticleController.php:2091
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from content_by_diseases where content_id = 121413 and content_type = 'article' order by status desc limit 1
      340μsalphaeurekaselec_live_10_06_2022Article.php#751
      Backtrace
      • 11. app/Models/Article.php:751
      • 12. app/Http/Controllers/ArticleController.php:2094
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select a.nid article_nid,a.title article_title,j.title journal_title from content_by_diseases cd inner join article a on a.article_id=cd.content_id inner join journal j on j.journal_id=a.journal_id where cd.pid = 622 and cd.sub_disease_id = 623 and content_id!=121413 and cd.content_type = 'article' order by rand() limit 20
      8.48msalphaeurekaselec_live_10_06_2022Article.php#769
      Backtrace
      • 11. app/Models/Article.php:769
      • 12. app/Http/Controllers/ArticleController.php:2098
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `node_meta` where `nid` = 201826 limit 1
      280μsalphaeurekaselec_live_10_06_2022Meta.php#30
      Bindings
      • 0: 201826
      Backtrace
      • 14. app/Models/Meta.php:30
      • 15. app/Http/Controllers/ArticleController.php:2101
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `bo`.* from `bundle_offer` as `bo` where `bo`.`bundle_status` = 'A' order by `bo`.`bundle_id` desc
      260μsalphaeurekaselec_live_10_06_2022BundleOffer.php#57
      Bindings
      • 0: A
      Backtrace
      • 13. app/Models/BundleOffer.php:57
      • 14. app/Http/Controllers/ArticleController.php:2108
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `tbl_ht_submission` as `h` where `h`.`subtitle` = 'CTMC' and (h.proposal_closing_date = 0 OR TO_DAYS(FROM_UNIXTIME(h.proposal_closing_date)) >= TO_DAYS(NOW())) order by `h`.`manuscript` asc
      420μsalphaeurekaselec_live_10_06_2022Article.php#2025
      Bindings
      • 0: CTMC
      Backtrace
      • 13. app/Models/Article.php:2025
      • 14. app/Http/Controllers/ArticleController.php:2112
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '121413' and content_type = 'a' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      430μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2186
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '11511' and content_type = 'i' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      380μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2207
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select count(*) as total_count, content_type_access_id as access_type from journal_access where content_type_id = '3201' and content_type = 'v' and ( (from_date <= CURDATE() and to_date >= CURDATE() and perpetual= 0) or (from_date is null and to_date is null and perpetual= 1) )
      330μsalphaeurekaselec_live_10_06_2022ContentAccess.php#647
      Backtrace
      • 11. app/Models/ContentAccess.php:647
      • 12. app/Http/Controllers/ArticleController.php:2231
      • 13. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 14. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3201) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3201) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"volume" as access_level,"" as issue_id,"" as article_id from `user_access_journal_volume_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.volume_id = 3201)
      5.04msalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2272
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11511) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11511) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"issue" as access_level,j.issue_id,"" as article_id from `user_access_issue_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.issue_id = 11511)
      650μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2297
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Trial Access" as access_base_text, CASE j.type WHEN 111 THEN true ELSE false END as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_trail` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 121413) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Subscribed" as access_base_text, false as terms_popup, "S" as content_download_type, null as restricted_user_access_key, null as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_corporate` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 121413) union (select j.user_access_id,j.volume_id,j.user_id,j.from_ip,j.to_ip,j.type,j.track,"Token Based Access" as access_base_text, false as terms_popup, "R" as content_download_type, j.uc_id as restricted_user_access_key, "v" as restricted_user_access_type, CASE j.track WHEN 0 THEN false ELSE true END as tracksAccessByVolume,"article" as access_level, j.issue_id, j.article_id from `user_access_article_token` as `j` inner join `user_access_info` as `info` on `j`.`user_access_id` = `info`.`user_access_id` where ((j.from_ip <= 309684047 and j.to_ip >=309684047 )) and ((j.from_date <= 1739988047 and j.to_date >= 1739988047 and j.perpetual= 0) or (j.from_date is null and j.to_date is null and j.perpetual= 1)) and j.article_id = 121413)
      610μsalphaeurekaselec_live_10_06_2022UserAccess.php#1266
      Backtrace
      • 13. app/Models/UserAccess/UserAccess.php:1266
      • 14. app/Http/Controllers/ArticleController.php:2329
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `first_page` < '629' and is_uploaded = 1 and issue_id = 11511 order by cast(first_page as SIGNED) desc limit 1
      470μsalphaeurekaselec_live_10_06_2022Article.php#1819
      Bindings
      • 0: 629
      Backtrace
      • 14. app/Models/Article.php:1819
      • 15. app/Http/Controllers/ArticleController.php:2470
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select * from `article` where `last_page` > '638' and is_uploaded = 1 and issue_id = 11511 order by cast(first_page as SIGNED) asc limit 1
      450μsalphaeurekaselec_live_10_06_2022Article.php#1831
      Bindings
      • 0: 638
      Backtrace
      • 14. app/Models/Article.php:1831
      • 15. app/Http/Controllers/ArticleController.php:2472
      • 16. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 17. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `language_id` from `multilanguage` where `short_code` = 'en'
      200μsalphaeurekaselec_live_10_06_2022ArticleController.php#2497
      Bindings
      • 0: en
      Backtrace
      • 14. app/Http/Controllers/ArticleController.php:2497
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 18. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select `source_lang_label`, `target_lang_label` from `multilanguage_labels` where `target_lang_id` = 1
      230μsalphaeurekaselec_live_10_06_2022MultiLanguage.php#23
      Bindings
      • 0: 1
      Backtrace
      • 13. app/Models/MultiLanguage.php:23
      • 14. app/Http/Controllers/ArticleController.php:2498
      • 15. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 16. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
    • select `id` from `multilanguage_article` where `article_id` = 121413 limit 1
      2.86msalphaeurekaselec_live_10_06_2022ArticleController.php#2506
      Bindings
      • 0: 121413
      Backtrace
      • 16. app/Http/Controllers/ArticleController.php:2506
      • 17. vendor/laravel/framework/src/Illuminate/Routing/Controller.php:54
      • 18. vendor/laravel/framework/src/Illuminate/Routing/ControllerDispatcher.php:43
      • 19. vendor/laravel/framework/src/Illuminate/Routing/Route.php:260
      • 20. vendor/laravel/framework/src/Illuminate/Routing/Route.php:206
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 38 and `b`.`banner_from_date` <= 1739988047 and `b`.`banner_to_date` >= 1739988047 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.13msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 38
      • 3: 1739988047
      • 4: 1739988047
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select b.banner_link, b.banner_name, b.banner_script, b.banner_remarks, b.banner_file_name, b.banner_placement, bd.content_type, bd.content_id from `tbl_banner` as `b` inner join `tbl_banner_detail` as `bd` on `bd`.`banner_id` = `b`.`banner_id` inner join `users` as `u` on `u`.`id` = `b`.`updated_by` inner join `journal` as `j` on `j`.`journal_id` = `bd`.`content_id` where `b`.`banner_journal` = 1 and `bd`.`content_type` = 'J' and `bd`.`content_id` = 38 and `b`.`banner_from_date` <= 1739988047 and `b`.`banner_to_date` >= 1739988047 and `b`.`banner_status` = 'A' order by `b`.`banner_id` desc
      1.11msalphaeurekaselec_live_10_06_2022Banner.php#95
      Bindings
      • 0: 1
      • 1: J
      • 2: 38
      • 3: 1739988047
      • 4: 1739988047
      • 5: A
      Backtrace
      • 13. app/Models/Banner.php:95
      • 14. app/Http/helpers.php:404
      • 17. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 18. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    • select count(*) as aggregate from `uc_cart_products` where cart_id='82e7b9ec3445ffda7a584e380d9c85c9'
      230μsalphaeurekaselec_live_10_06_2022Cart.php#271
      Backtrace
      • 15. app/Models/Cart.php:271
      • 16. view::layouts._header:260
      • 18. vendor/laravel/framework/src/Illuminate/Filesystem/Filesystem.php:124
      • 19. vendor/laravel/framework/src/Illuminate/View/Engines/PhpEngine.php:58
      • 20. vendor/laravel/framework/src/Illuminate/View/Engines/CompilerEngine.php:73
    App\Models\MultiLanguage
    1MultiLanguage.php#?
        _token
        4vIm1nsJvR2tSV7Ag0Xyebb8cB8iPIxI3azNJAgK
        uc_cart_id
        82e7b9ec3445ffda7a584e380d9c85c9
        _previous
        array:1 [ "url" => "http://alpha.eurekaselect.com/article/121413" ]
        _flash
        array:2 [ "old" => [] "new" => [] ]
        PHPDEBUGBAR_STACK_DATA
        []
        path_info
        /article/121413
        status_code
        200
        
        status_text
        OK
        format
        html
        content_type
        text/html; charset=UTF-8
        request_query
        []
        
        request_request
        []
        
        request_headers
        0 of 0
        array:9 [ "cookie" => array:1 [ 0 => "wayfindertarget=eyJpdiI6IjVSako3dDRhNERvTmxEQTNONlV0MEE9PSIsInZhbHVlIjoiRUdoR3NvMFg0YXo3YS9LQ2Fvclc4R2FldUthQ3RBd3N5M0FMeGJUR1VnND0iLCJtYWMiOiIxZWJhODU0OWQ5YTQzMTAyNzVjNzZjY2U5YTUzOWM0Mzg1YmU2OGRiYjQwMWFhOWQ2NWU1Y2UzYWJkNzBhNGY5IiwidGFnIjoiIn0%3Dwayfindertarget=eyJpdiI6IjVSako3dDRhNERvTmxEQTNONlV0MEE9PSIsInZhbHVlIjoiRUdoR3NvMFg0YXo3YS9LQ2Fvclc4R2FldUthQ3RBd3N5M0FMeGJUR1VnND0iLCJtYWMiOiIxZWJhODU0OWQ5YTQz" ] "accept-encoding" => array:1 [ 0 => "gzip, deflate" ] "accept" => array:1 [ 0 => "text/html,application/xhtml+xml,application/xml;q=0.9,image/avif,image/webp,image/apng,*/*;q=0.8,application/signed-exchange;v=b3;q=0.7" ] "user-agent" => array:1 [ 0 => "Mozilla/5.0 AppleWebKit/537.36 (KHTML, like Gecko; compatible; ClaudeBot/1.0; +claudebot@anthropic.com)" ] "upgrade-insecure-requests" => array:1 [ 0 => "1" ] "cache-control" => array:1 [ 0 => "no-cache" ] "pragma" => array:1 [ 0 => "no-cache" ] "connection" => array:1 [ 0 => "keep-alive" ] "host" => array:1 [ 0 => "alpha.eurekaselect.com" ] ]
        request_cookies
        0 of 0
        array:1 [ "wayfindertarget" => null ]
        response_headers
        0 of 0
        array:5 [ "content-type" => array:1 [ 0 => "text/html; charset=UTF-8" ] "cache-control" => array:1 [ 0 => "no-cache, private" ] "date" => array:1 [ 0 => "Wed, 19 Feb 2025 18:00:47 GMT" ] "set-cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImkzQjdCMW9jcm0zd25yRCtCbWdVN1E9PSIsInZhbHVlIjoiT2t0QXZsOWhOM1ZSaEFYQ3JTa2xxRVFKMk14TCtFZi96MzdPMEtaMExxM2tYb2lUOWI3eWYvZFlBU1gzQndBZVFGQSs0VlhiMy9CeTRFNjI3VXo1ZnM3eDZadjJnNkhiWFRaQ1MwNlRyQkFxSlF6T25FcXAyMTJ2TXJUd2JjZXciLCJtYWMiOiJiNGU0MWI1MzRkYzVhNGVjOWNiYjdmNGFjNDAyMWM1NmZhZmJiZmUxNTA1N2E5MWFlYzYyY2ExYjMwYWFmNTBlIiwidGFnIjoiIn0%3D; expires=Sat, 22 Feb 2025 06:00:47 GMT; Max-Age=216000; path=/; secure; samesite=laxXSRF-TOKEN=eyJpdiI6ImkzQjdCMW9jcm0zd25yRCtCbWdVN1E9PSIsInZhbHVlIjoiT2t0QXZsOWhOM1ZSaEFYQ3JTa2xxRVFKMk14TCtFZi96MzdPMEtaMExxM2tYb2lUOWI3eWYvZFlBU1gzQndBZVFGQSs0V" 1 => "alphaeurekaselectnet_session=eyJpdiI6IisvTTcxMlorZGZsTnJqNGxUR2dJN3c9PSIsInZhbHVlIjoickVOT21EY0dxbGN6TGJHQzZPd0x1aU92djljMUpSK0lLaW9aWjlsQWUydURaR1FKV1BtTGh3TjhrdE1xd2hxbE15WDBoVTI3ektvcXdrNU5iR2xhTE5DQlhsZGsrUEZiRzVCc01xVEIweWlIMS9sMTYvZTNGUDhmMjFHeGdYMjMiLCJtYWMiOiI2NDA5Y2RjOThkNTQ2OGM0MDE0MzIzMjVmMDhiYmViOGE0Yjg2MWJmODZkZWI3MTA5NDJmZmY2MTJmZTUwOGJmIiwidGFnIjoiIn0%3D; path=/; secure; httponly; samesite=laxalphaeurekaselectnet_session=eyJpdiI6IisvTTcxMlorZGZsTnJqNGxUR2dJN3c9PSIsInZhbHVlIjoickVOT21EY0dxbGN6TGJHQzZPd0x1aU92djljMUpSK0lLaW9aWjlsQWUydURaR1FKV1BtTGh3Tjh" ] "Set-Cookie" => array:2 [ 0 => "XSRF-TOKEN=eyJpdiI6ImkzQjdCMW9jcm0zd25yRCtCbWdVN1E9PSIsInZhbHVlIjoiT2t0QXZsOWhOM1ZSaEFYQ3JTa2xxRVFKMk14TCtFZi96MzdPMEtaMExxM2tYb2lUOWI3eWYvZFlBU1gzQndBZVFGQSs0VlhiMy9CeTRFNjI3VXo1ZnM3eDZadjJnNkhiWFRaQ1MwNlRyQkFxSlF6T25FcXAyMTJ2TXJUd2JjZXciLCJtYWMiOiJiNGU0MWI1MzRkYzVhNGVjOWNiYjdmNGFjNDAyMWM1NmZhZmJiZmUxNTA1N2E5MWFlYzYyY2ExYjMwYWFmNTBlIiwidGFnIjoiIn0%3D; expires=Sat, 22-Feb-2025 06:00:47 GMT; path=/; secureXSRF-TOKEN=eyJpdiI6ImkzQjdCMW9jcm0zd25yRCtCbWdVN1E9PSIsInZhbHVlIjoiT2t0QXZsOWhOM1ZSaEFYQ3JTa2xxRVFKMk14TCtFZi96MzdPMEtaMExxM2tYb2lUOWI3eWYvZFlBU1gzQndBZVFGQSs0V" 1 => "alphaeurekaselectnet_session=eyJpdiI6IisvTTcxMlorZGZsTnJqNGxUR2dJN3c9PSIsInZhbHVlIjoickVOT21EY0dxbGN6TGJHQzZPd0x1aU92djljMUpSK0lLaW9aWjlsQWUydURaR1FKV1BtTGh3TjhrdE1xd2hxbE15WDBoVTI3ektvcXdrNU5iR2xhTE5DQlhsZGsrUEZiRzVCc01xVEIweWlIMS9sMTYvZTNGUDhmMjFHeGdYMjMiLCJtYWMiOiI2NDA5Y2RjOThkNTQ2OGM0MDE0MzIzMjVmMDhiYmViOGE0Yjg2MWJmODZkZWI3MTA5NDJmZmY2MTJmZTUwOGJmIiwidGFnIjoiIn0%3D; path=/; secure; httponlyalphaeurekaselectnet_session=eyJpdiI6IisvTTcxMlorZGZsTnJqNGxUR2dJN3c9PSIsInZhbHVlIjoickVOT21EY0dxbGN6TGJHQzZPd0x1aU92djljMUpSK0lLaW9aWjlsQWUydURaR1FKV1BtTGh3Tjh" ] ]
        session_attributes
        0 of 0
        array:5 [ "_token" => "4vIm1nsJvR2tSV7Ag0Xyebb8cB8iPIxI3azNJAgK" "uc_cart_id" => "82e7b9ec3445ffda7a584e380d9c85c9" "_previous" => array:1 [ "url" => "http://alpha.eurekaselect.com/article/121413" ] "_flash" => array:2 [ "old" => [] "new" => [] ] "PHPDEBUGBAR_STACK_DATA" => [] ]
        ClearShow all
        Date ↕MethodURLData
        #12025-02-19 18:00:47GET/article/121413414371