Abstract
Backgrounds: Plant and derived herbal drugs have been used in the traditional medicine system to treat various human health complications from a very early age. Commercial products prepared from natural herbs have always been valuable for society in the form of health supplements to medicament. In ancient times, herbal products were mainly prepared from plants and derived phytochemicals. Plants contain a rich source of pure phytochemicals called secondary metabolites, and examples are flavonoids, glycosides, tannins, terpenoids, etc. Plants and their parts, including fruits, flowers, vegetables, etc., are the best source of Flavonoid class phytochemicals.
Methods: Present work summarized the scientific information of karanjin for their beneficial health aspects and pharmacological activities, including its analytical aspects. In the present investigation, scientific data on karanjin have been collected from various scientific databases such as Google, Google Scholar, Science Direct, and PubMed and analyzed to know the beneficial health aspects of karanjin in medicine. Further pharmacological activity data has been collected and analyzed in the present work to know their biological potential in medicine. Analytical methods used for the separation, isolation, and identification of karanjin to standardize different natural products have also been discussed in the present work.
Results: Scientific data analysis signified the biological importance of Flavonoid class phytochemicals in the medicine as they are well known for their anti-ischemic, vasodilatory, anti-bacterial, antiinflammatory, anti-oxidant, anti-viral, and anti-cancer activities. Scientific data analysis revealed the presence of karanjin in numerous medicinal plants such as Fordia cauliflora, Lonchocarpus latifolius, Millettia pinnata, Millettia pubinervis, Pongamia pinnata, and Tephrosia purpurea. Pharmacological activity data revealed the biological potential of karanjin against cancerous disorders, glucose metabolism abnormalities, gastrointestinal disorders, arthritis, inflammatory disorders, colitis, psoriasis, and brain-related disorders. However, analytical data signified the importance of RP-HPLC, TLC, HPTLC, UPLC-ESI-MS/MS, and HSCCC techniques in the medicine to quantify karanjin in different samples.
Conclusion: Presented information about karanjin in this review paper will be beneficial to the scientific peoples of the world to know the beneficial health aspects of karanjin in medicine.
Keywords: Karanjin, flavonoid, cancer, glucose metabolism, gastrointestinal disorders, arthritis, inflammatory disorders, colitis, psoriasis, brain disorders.
Graphical Abstract
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