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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Relationship between Gut Microbiota and Bone Health

Author(s): Ke You, Lianjun Yang, Jun Shen, Bin Liu, Yuanqing Guo, Tao Chen, Guowei Li and Hai Lu*

Volume 22, Issue 18, 2022

Published on: 22 April, 2022

Page: [2406 - 2418] Pages: 13

DOI: 10.2174/1389557522666220304230920

Price: $65

Abstract

Gut Microbiota (GM) are microorganisms that live in the host gastrointestinal tract, and their abundance varies throughout the host’s life. With the development of sequencing technology, the role of GM in various diseases has been increasingly elucidated. Unlike earlier studies on orthopedic diseases, this review elucidates the correlation between GM health and bone health and discusses the potential mechanism of GM effects on host metabolism, inflammation, and ability to induce or aggravate some common orthopedic diseases, such as osteoarthritis, osteoporosis, rheumatoid arthritis, etc. Finally, the prospective methods of GM manipulation and evaluation of potential GM-targeting strategies in the diagnosis and treatment of orthopedic diseases are reviewed.

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