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Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Editorial

Recent Advances in the Use of Multitarget Therapeutics

Author(s): Daniel Alencar Rodrigues

Volume 22, Issue 5, 2022

Published on: 04 March, 2022

Page: [331 - 332] Pages: 2

DOI: 10.2174/156802662205220304155829

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[1]
Wermuth, C.G. Multitargeted drugs: the end of the “one-target-one-disease” philosophy? Drug Discov. Today, 2004, 9(19), 826-827.
[2]
Morphy, R.; Kay, C.; Rankovic, Z. From magic bullets to designed multiple ligands. Drug Discov. Today, 2004, 9, 641-651.
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Peters, J.U. Polypharmacology - foe or friend? J. Med. Chem., 2013, 56(22), 8955-8971.
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Viegas-Junior, C.; Danuello, A.; da Silva Bolzani, V.; Barreiro, E.J.; Fraga, C.A.M. Molecular hybridization: a useful tool in the design of new drug prototypes. Curr. Med. Chem., 2007, 14, 1829-1852.
[5]
Ivasiv, V.; Albertini, C.; Goncalves, A.E.; Rossi, M.; Bolognesi, M.L. Molecular hybridization as a tool for designing multitarget drug candidates for complex diseases. Curr. Top. Med. Chem., 2019, 19(19), 1694-1711.
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Garuti, L.; Roberti, M.; Bottegoni, G. Multi-kinase inhibitors. Curr. Med. Chem., 2015, 22(6), 695-712.
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Gentile, C.; Martorana, A.; Lauria, A.; Bonsignore, R. Kinase inhibitors in multitargeted cancer therapy. Curr. Med. Chem., 2017, 24(16), 1671-1686.
[8]
Castro, L.H.E.; Sant’Anna, C.M.R. Molecular modeling techniques applied to the design of multitarget drugs: methods and applications. Curr. Top. Med. Chem., 2022, 22(5), 333-346.
[9]
Kaur, R.; Sood, A.; Lang, D.K.; Rashmi, A.; Kumar, N.; Vishal, D.; Balraj, S. Natural products as sources of multitarget compounds: advances in the development of ferulic acid as multitarget therapeutic. Curr. Top. Med. Chem., 2022, 22(5), 347-365.
[10]
Caruso, L.; Nadur, N.F.; Brandão, M.; Ferreira, L.d.A.P; Lacerda, R.B.; Graebin, C.S.; Kümmerle, A.E. The design of multi-target drugs to treat cardiovascular diseases: two (or more) birds on one stone. Curr. Top. Med. Chem., 2022, 22(5), 366-394.
[11]
Gulcan, H.O.; Kosar, M. The hybrid compounds as multi-target ligands for the treatment of alzheimer’s disease: considerations on donepezil. Curr. Top. Med. Chem., 2022, 22(5), 395-407.
[12]
Rodrigues, D.A.; Roe, A.; Griffith, D.; Ní Chonghaile, T. Advances in the design and development of PROTAC-mediated HDAC degradation. Curr. Top. Med. Chem., 2022, 22(5), 408-424.

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