摘要
背景:自武汉首次报告以来,当前的2019冠状病毒病(COVID-19)大流行激励了全球努力制定有效的COVID-19疫苗接种策略。编码COVID-19抗原的mRNA疫苗因其高效和简单的制造工艺而在这场全球竞赛中脱颖而出。值得注意的是,两种COVID-19 mRNA疫苗mRNA-1273和BNT162b2在临床试验中存活下来,并获准在各国紧急使用。 综述:从这个角度讨论了COVID-19 mRNA疫苗的最新进展,包括序列设计、化学修饰、生产工艺和体内交付。总结mRNA-1273和BNT162b2的I期至IV期临床试验。 结论:mRNA疫苗是实现COVID-19大流行大规模疫苗接种的一种有前景的策略。我们希望未来mRNA疫苗技术的研究能够克服现有的局限性,帮助人们应对COVID-19。
关键词: 新冠肺炎(COVID-19), SARS-CoV-2, mRNA疫苗,化学修饰,mRNA- 1273, BNT162b2。
Current Medicinal Chemistry
Title:Perspectives and Prospects on mRNA Vaccine Development for COVID-19
Volume: 29 Issue: 23
关键词: 新冠肺炎(COVID-19), SARS-CoV-2, mRNA疫苗,化学修饰,mRNA- 1273, BNT162b2。
摘要:
Background: The current coronavirus disease 2019 (COVID-19) pandemic, since first reported in Wuhan, has inspired worldwide efforts to develop effective COVID-19 vaccination strategies. mRNA vaccines encoding COVID-19 antigens have emerged prominantlyin this global race due to their high effectiveness and simple manufacturing process. Notably, two COVID-19 mRNA vaccines, mRNA-1273 and BNT162b2, have survived in clinical trials and been authorized for emergency use across variouscountries.
Summary: Recent advances on mRNA vaccine development for COVID-19 are discussed in this perspective, including sequence design, chemical modification, manufacturing process, and in vivo delivery. Phase I to IV clinical trials of mRNA-1273 and BNT162b2 are then summarized, respectively.
Conclusion: Using mRNA vaccines is a promising strategy to achieve mass vaccination in the COVID-19 pandemic. We hope that future studies of mRNA vaccine technology will overcome existing limitations and help people cope with COVID-19.
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Cite this article as:
Perspectives and Prospects on mRNA Vaccine Development for COVID-19, Current Medicinal Chemistry 2022; 29 (23) . https://dx.doi.org/10.2174/0929867329666220216110931
DOI https://dx.doi.org/10.2174/0929867329666220216110931 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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