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ISSN (Online): 1875-5607

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Review Article

Biological Activities, Pharmacokinetics and Toxicity of Nootkatone: A Review

Author(s): Ankush Kumar Jha, Shobhit Gairola, Sourav Kundu, Pakpi Doye, Abu Mohammad Syed, Chetan Ram, Uttam Kulhari, Naresh Kumar, Upadhyayula Suryanarayana Murty and Bidya Dhar Sahu*

Volume 22, Issue 17, 2022

Published on: 19 April, 2022

Page: [2244 - 2259] Pages: 16

DOI: 10.2174/1389557522666220214092005

Price: $65

Abstract

Plant-based drugs have a significant impact on modern therapeutics due to their vast array of pharmacological activities. The integration of herbal plants in the current healthcare system has emerged as a new field of research. It can be used for the identification of novel lead compound candidates for future drug development. Nootkatone is a sesquiterpene derivative and an isolate of grapefruit. Shreds of evidence illustrate that nootkatone targets few molecular mechanisms to exhibit its pharmacological activity and yet needs more exploration. The current review is related to nootkatone, drafted through a literature search using research articles and books from different sources, including Science Direct, Google Scholar, Elsevier, PubMed, and Scopus. It has been reported to possess a wide range of pharmacological activities such as anti-inflammatory, anticancer, antibacterial, hepatoprotective, neuroprotective, and cardioprotective. Although preclinical studies in experimental animal models suggest that nootkatone has therapeutic potential, it is further warranted to evaluate its toxicity and pharmacokinetic parameters before being applied to humans. Hence, in the present review, we have summarized the scientific knowledge on nootkatone with a particular emphasis on its pharmacological properties to encourage researchers for further exploration in preclinical and clinical settings.

Keywords: Nootkatone, pharmacological activities, pharmacokinetic, toxicity, anticancer, anti-inflammatory.

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