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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

通过生物信息学方法全面研究阿尔茨海默病和癫痫之间的分子特征和通道

卷 19, 期 2, 2022

发表于: 08 March, 2022

页: [146 - 160] 页: 15

弟呕挨: 10.2174/1567205019666220202120638

价格: $65

摘要

背景：在阿尔茨海默病（AD）患者身上经常出现癫痫的症状，这可能会加快AD的发展；然而，AD和癫痫之间的关系仍然不清楚。 目标：我们旨在利用生物信息学方法来研究AD和癫痫之间的分子通道和基因。 方法：AD（GSE1297）和癫痫（GSE28674）的基因表达谱源自基因表达综合（GEO）数据库。前50%的表达变体进行了加权基因共表达网络分析（WGCNA），以辨别与这些疾病相关的关键模块。对关键模块进行了基因本体论（GO）和京都基因和基因组百科全书（KEGG）分析，并选择了关键模块中功能丰富和常见基因的交叉部分。对部分重叠的基因进行了蛋白质-蛋白质相互作用（PPI）网络、转录因子（TF）-mRNA网络、microRNA（miRNA）-mRNA网络和药物预测的分析。 结果：我们分别在AD相关紫色和癫痫相关蓝色模块中确定了229个和1187个基因。两个模块之间的六个共享功能部分包括“钙离子结合”和“钙信号通路”。根据发现的17个常见基因，建立了130个TFmRNA对和56个miRNA-mRNA对。对构建的调控网络的拓扑分析表明，TF-FOXC1和miRNA-hsa-mir-335-5p可能是AD和癫痫中重要的基因表达的共同调节因子。此外，CXCR4被确定为枢纽基因，成为20种药物的推定的靶点。 结论：我们的研究对AD和癫痫之间的分子联系阐明了新的见解，这可能有助于探索共同机制和设计疾病改良疗法。

关键词: 阿尔茨海默病，癫痫，钙，miRNA，转录因子，网络

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