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Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Review Article

Clinical Evaluation of Exertional Dyspnea in Adult Pectus Excavatum Patients

Author(s): Mateo C. Houle*, Tyson J. Sjulin, Ian C. McInnis, Robert J. Walter and Michael J. Morris

Volume 18, Issue 1, 2022

Published on: 25 February, 2022

Page: [12 - 19] Pages: 8

DOI: 10.2174/1573398X18666220128110107

Price: $65

Abstract

Evaluation of patients with pectus excavatum has primarily been focused on, especially the pediatric population who undergoes surgical correction of sternal defects mainly for cosmetic reasons combined with exercise-limiting symptoms. The extent of cardiopulmonary improvement in this population based on cardiac imaging, pulmonary function testing, and cardiopulmonary exercise testing may be highly variable. There is no current consensus on the limitations of cardiopulmonary impairment or potential improvement from surgical repair in pediatric patients. Limited data have been published in the medical literature on the evaluation of adults with pectus excavatum who may also present with a variety of clinical symptoms. Adult patients with exercise limitation and pectus excavatum may present with exertional dyspnea, chest discomfort, palpitations/tachycardia, exercise-induced wheezing, and use of bronchodilators for asthma-like symptoms. While numerous published review articles outline clinical evaluation and surgical treatment for younger patients, comprehensive evaluation for these adult patients has not been fully elucidated. There is no current consensus on the underlying cause of cardiopulmonary impairment in adult patients or their potential improvement from surgical repair. This review focuses on the recommended evaluation of adult patients to discern the potential cardiopulmonary limitations to exercise due to pectus excavatum, especially in physically fit adults, such as active-duty military personnel. Two illustrative cases are presented to describe the complexity of the evaluation for adult patients and the potential need for surgical correction.

Keywords: Clinical evaluation, exertional dyspnea, adult, pectus excavatum, patients, MVV.

Graphical Abstract

[1]
Nuss D, Kelly RE Jr. Minimally invasive surgical correction of chest wall deformities in children (Nuss procedure). Adv Pediatr 2008; 55(1): 395-410.
[http://dx.doi.org/10.1016/j.yapd.2008.07.012] [PMID: 19048741]
[2]
Bay V, Farthmann E, Naegele U. Unoperated funnel chest in middle and advances age: evaluation of indications for operation. J Pediatr Surg 1970; 5(6): 606-9.
[http://dx.doi.org/10.1016/S0022-3468(70)80004-5] [PMID: 5502888]
[3]
Shamberger RC. Cardiopulmonary effects of anterior chest wall deformities. Chest Surg Clin N Am 2000; 10(2): 245-52.
[PMID: 10803331]
[4]
Fonkalsrud EW, DeUgarte D, Choi E. Repair of pectus excavatum and carinatum deformities in 116 adults. Ann Surg 2002; 236(3): 304-12.
[http://dx.doi.org/10.1097/00000658-200209000-00007] [PMID: 12192317]
[5]
Weg JG, Krumholz RA, Harkleroad LE. Pulmonary dysfunction in pectus excavatum. Am Rev Respir Dis 1967; 96(5): 936-45.
[PMID: 6059202]
[6]
Tardie GB, Dorsey DA, Kaeferlein BH. Evaluation of unexplained dyspnea in a young athletic male with pectus excavatum. J Sports Sci Med 2005; 4(3): 323-31.
[PMID: 24453537]
[7]
Kowalewski J, Barcikowski S, Brocki M. Cardiorespiratory function before and after operation for pectus excavatum: Medium-term results. Eur J Cardiothorac Surg 1998; 13(3): 275-9.
[http://dx.doi.org/10.1016/S1010-7940(97)00326-6] [PMID: 9628377]
[8]
Zhao L, Feinberg MS, Gaides M, Ben-Dov I. Why is exercise capacity reduced in subjects with pectus excavatum? J Pediatr 2000; 136(2): 163-7.
[http://dx.doi.org/10.1016/S0022-3476(00)70096-5] [PMID: 10657820]
[9]
Kelly RE Jr, Shamberger RC, Mellins RB, et al. Prospective multicenter study of surgical correction of pectus excavatum: Design, perioperative complications, pain, and baseline pulmonary function facilitated by internet-based data collection. J Am Coll Surg 2007; 205(2): 205-16.
[http://dx.doi.org/10.1016/j.jamcollsurg.2007.03.027] [PMID: 17660066]
[10]
Kelly RE Jr, Mellins RB, Shamberger RC, et al. Multicenter study of pectus excavatum, final report: complications, static/exercise pulmonary function, and anatomic outcomes. J Am Coll Surg 2013; 217(6): 1080-9.
[http://dx.doi.org/10.1016/j.jamcollsurg.2013.06.019] [PMID: 24246622]
[11]
Jaroszewski DE, Velazco CS, Pulivarthi VSKK, Arsanjani R, Obermeyer RJ. Cardiopulmonary function in thoracic wall deformities: What do we really know? Eur J Pediatr Surg 2018; 28(4): 327-46.
[http://dx.doi.org/10.1055/s-0038-1668130] [PMID: 30103240]
[12]
Koumbourlis AC. Pectus deformities and their impact on pulmonary physiology. Paediatr Respir Rev 2015; 16(1): 18-24.
[PMID: 25464892]
[13]
St Peter SD, Juang D, Garey CL, et al. A novel measure for pectus excavatum: the correction index. J Pediatr Surg 2011; 46(12): 2270-3.
[http://dx.doi.org/10.1016/j.jpedsurg.2011.09.009] [PMID: 22152863]
[14]
Malek MH, Berger DE, Marelich WD, Coburn JW, Beck TW, Housh TJ. Pulmonary function following surgical repair of pectus excavatum: A meta-analysis. Eur J Cardiothorac Surg 2006; 30(4): 637-43.
[http://dx.doi.org/10.1016/j.ejcts.2006.07.004] [PMID: 16901712]
[15]
Morshuis W, Folgering H, Barentsz J, van Lier H, Lacquet L. Pulmonary function before surgery for pectus excavatum and at long-term follow-up. Chest 1994; 105(6): 1646-52.
[http://dx.doi.org/10.1378/chest.105.6.1646] [PMID: 8205855]
[16]
Morshuis WJ, Folgering HT, Barentsz JO, Cox AL, van Lier HJ, Lacquet LK. Exercise cardiorespiratory function before and one year after operation for pectus excavatum. J Thorac Cardiovasc Surg 1994; 107(6): 1403-9.
[http://dx.doi.org/10.1016/S0022-5223(94)70414-7] [PMID: 8196380]
[17]
Lawson ML, Mellins RB, Tabangin M, et al. Impact of pectus excavatum on pulmonary function before and after repair with the Nuss procedure. J Pediatr Surg 2005; 40(1): 174-80.
[http://dx.doi.org/10.1016/j.jpedsurg.2004.09.040] [PMID: 15868581]
[18]
Coskun ZK, Turgut HB, Demirsoy S, Cansu A. The prevalence and effects of pectus excavatum and pectus carinatum on the respiratory function in children between 7-14 years old. Indian J Pediatr 2010; 77(9): 1017-9.
[http://dx.doi.org/10.1007/s12098-010-0155-5] [PMID: 20814837]
[19]
Sesia SB, Obermeyer RJ, Mayr J, Haecker FM. Pulmonary function in pectus excavatum patients before repair with the Nuss procedure. Postgrad Med 2016; 128(6): 598-602.
[http://dx.doi.org/10.1080/00325481.2016.1205454] [PMID: 27352619]
[20]
Derveaux L, Clarysse I, Ivanoff I, Demedts M. Preoperative and postoperative abnormalities in chest x-ray indices and in lung function in pectus deformities. Chest 1989; 95(4): 850-6.
[http://dx.doi.org/10.1378/chest.95.4.850] [PMID: 2924614]
[21]
Koumbourlis AC, Stolar CJ. Lung growth and function in children and adolescents with idiopathic pectus excavatum. Pediatr Pulmonol 2004; 38(4): 339-43.
[http://dx.doi.org/10.1002/ppul.20062] [PMID: 15334513]
[22]
Fonkalsrud EW. 912 open pectus excavatum repairs: Changing trends, lessons learned: One surgeon’s experience. World J Surg 2009; 33(2): 180-90.
[http://dx.doi.org/10.1007/s00268-008-9793-4] [PMID: 19002739]
[23]
Shimoyama S, Kobayashi T, Inoue Y, et al. Left displacement of the mediastinum determines the imbalance in the pulmonary vascular bed and lung volume in children with pectus excavatum. Pediatr Surg Int 2008; 24(5): 549-53.
[http://dx.doi.org/10.1007/s00383-008-2135-7] [PMID: 18357458]
[24]
Kao CH, Liao SQ, Wang SJ, Yeh SH. Pulmonary scintigraphic findings in children with pectus excavatum by the comparison of chest radiograph indices. Clin Nucl Med 1992; 17(11): 874-6.
[http://dx.doi.org/10.1097/00003072-199211000-00008] [PMID: 1424376]
[25]
Blickman JG, Rosen PR, Welch KJ, Papanicolaou N, Treves ST. Pectus excavatum in children: Pulmonary scintigraphy before and after corrective surgery. Radiology 1985; 156(3): 781-2.
[http://dx.doi.org/10.1148/radiology.156.3.4023243] [PMID: 4023243]
[26]
Kinuya K, Ueno T, Kobayashi T, Tuji T, Yamamoto Y, Kinuya S. Tc-99m MAA SPECT in pectus excavatum: assessment of perfusion volume changes after correction by the Nuss procedure. Clin Nucl Med 2005; 30(12): 779-82.
[http://dx.doi.org/10.1097/01.rlu.0000186854.41771.8f] [PMID: 16319631]
[27]
Gürkan U, Aydemir B, Aksoy S, et al. Echocardiographic assessment of right ventricular function before and after surgery in patients with pectus excavatum and right ventricular compression. Thorac Cardiovasc Surg 2014; 62(3): 231-5.
[PMID: 23619591]
[28]
Sigalet DL, Montgomery M, Harder J, Wong V, Kravarusic D, Alassiri A. Long term cardiopulmonary effects of closed repair of pectus excavatum. Pediatr Surg Int 2007; 23(5): 493-7.
[http://dx.doi.org/10.1007/s00383-006-1861-y] [PMID: 17252283]
[29]
Peterson RJ, Young WG Jr, Godwin JD, Sabiston DC Jr, Jones RH. Noninvasive assessment of exercise cardiac function before and after pectus excavatum repair. J Thorac Cardiovasc Surg 1985; 90(2): 251-60.
[http://dx.doi.org/10.1016/S0022-5223(19)38626-X] [PMID: 4021526]
[30]
Oezcan S, Attenhofer Jost CH, Pfyffer M, et al. Pectus excavatum: echocardiography and cardiac MRI reveal frequent pericardial effusion and right-sided heart anomalies. Eur Heart J Cardiovasc Imaging 2012; 13(8): 673-9.
[http://dx.doi.org/10.1093/ehjci/jer284] [PMID: 22298154]
[31]
Jaroszewski DE, Ewais MM, Chao CJ, et al. Success of minimally invasive pectus excavatum procedures (modified nuss) in adult patients (≥30 years). Ann Thorac Surg 2016; 102(3): 993-1003.
[http://dx.doi.org/10.1016/j.athoracsur.2016.03.105] [PMID: 27283111]
[32]
Haller JA Jr, Peters GN, Mazur D, White JJ. Pectus excavatum. A 20 year surgical experience. J Thorac Cardiovasc Surg 1970; 60(3): 375-83.
[http://dx.doi.org/10.1016/S0022-5223(19)42349-0] [PMID: 5451734]
[33]
Ghory MJ, James FW, Mays W. Cardiac performance in children with pectus excavatum. J Pediatr Surg 1989; 24(8): 751-5.
[http://dx.doi.org/10.1016/S0022-3468(89)80530-5] [PMID: 2769541]
[34]
Malek MH, Fonkalsrud EW, Cooper CB. Ventilatory and cardiovascular responses to exercise in patients with pectus excavatum. Chest 2003; 124(3): 870-82.
[http://dx.doi.org/10.1378/chest.124.3.870] [PMID: 12970011]
[35]
Neviere R, Montaigne D, Benhamed L, et al. Cardiopulmonary response following surgical repair of pectus excavatum in adult patients. Eur J Cardiothorac Surg 2011; 40(2): e77-82.
[http://dx.doi.org/10.1016/j.ejcts.2011.03.045] [PMID: 21570313]
[36]
Cahill JL, Lees GM, Robertson HT. A summary of preoperative and postoperative cardiorespiratory performance in patients undergoing pectus excavatum and carinatum repair. J Pediatr Surg 1984; 19(4): 430-3.
[http://dx.doi.org/10.1016/S0022-3468(84)80268-7] [PMID: 6481587]
[37]
Yeh SW, Yang MC, Chang YW, Hsu YT, Tzeng IS, Cheng YL. Improved dynamics of thoracic cage and exercise capacity after nuss repair for pectus excavatum. Thorac Cardiovasc Surg 2020; 68(1): 85-91.
[http://dx.doi.org/10.1055/s-0039-1683384] [PMID: 30861534]
[38]
Skoczynski S, Koszutski T, Bunarowska M, et al. Respiratory long term outcomes of pectus excavatum in patients after Nuss surgery. Eur Resp J 2016; 48: PA3558.
[39]
Wynn SR, Driscoll DJ, Ostrom NK, et al. Exercise cardiorespiratory function in adolescents with pectus excavatum. Observations before and after operation. J Thorac Cardiovasc Surg 1990; 99(1): 41-7.
[http://dx.doi.org/10.1016/S0022-5223(19)35630-2] [PMID: 2294364]
[40]
Wallaert B, Cavestri B, Fournier C, Nevière R, Aguilaniu B. Positional hyperventilation-induced hypoxaemia in pectus excavatum. Eur Respir J 2006; 28(1): 243-7.
[http://dx.doi.org/10.1183/09031936.06.00096005] [PMID: 16816351]
[41]
Godfrey S. Association between pectus excavatum and segmental bronchomalacia. J Pediatr 1980; 96(4): 649-52.
[http://dx.doi.org/10.1016/S0022-3476(80)80731-1] [PMID: 7359268]
[42]
Kamiyama M, Usui N, Tani G, Nose K, Kimura T, Fukuzawa M. Airway deformation in patients demonstrating pectus excavatum with an improvement after the Nuss procedure. Pediatr Surg Int 2011; 27(1): 61-6.
[http://dx.doi.org/10.1007/s00383-010-2709-z] [PMID: 21113603]
[43]
Kim DH, Hwang JJ, Lee MK, Lee DY, Paik HC. Analysis of the Nuss procedure for pectus excavatum in different age groups. Ann Thorac Surg 2005; 80(3): 1073-7.
[http://dx.doi.org/10.1016/j.athoracsur.2005.03.070] [PMID: 16122489]

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