Abstract
Small double stranded RNA molecules known as small interfering RNA (siRNA), initially identified for their role in the guide sequence in the effector complex of the RNA interference pathway, now represent a promising new class of therapeutic agent with potentially important clinical applications for the prevention and treatment of viral disease. siRNA with its ability to harness the cells own gene-silencing apparatus in a highly adaptable and sequence specific manner has demonstrated unprecedented anti-gene activity. This review highlights the key chemical and biological parameters of this technology and its application in viral suppression, particularly in the respiratory tract. This treatment site represents both an important opportunity to establish clinical exposure for the technology, and an important challenge to provide an additional layer of protection against highly threatening influenza epidemics and potential pandemics.
Keywords: siRNA, RNA interference, influenza, PTGS, respiratory tract, pandemic, liposome and anti-viral
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry
Title: Small Interfering RNAs and their Therapeutic Applications in Mitigation of Virus Replication and Pathological Effects in the Respiratory Tract
Volume: 7 Issue: 2
Author(s): Murray J. Cairns
Affiliation:
Keywords: siRNA, RNA interference, influenza, PTGS, respiratory tract, pandemic, liposome and anti-viral
Abstract: Small double stranded RNA molecules known as small interfering RNA (siRNA), initially identified for their role in the guide sequence in the effector complex of the RNA interference pathway, now represent a promising new class of therapeutic agent with potentially important clinical applications for the prevention and treatment of viral disease. siRNA with its ability to harness the cells own gene-silencing apparatus in a highly adaptable and sequence specific manner has demonstrated unprecedented anti-gene activity. This review highlights the key chemical and biological parameters of this technology and its application in viral suppression, particularly in the respiratory tract. This treatment site represents both an important opportunity to establish clinical exposure for the technology, and an important challenge to provide an additional layer of protection against highly threatening influenza epidemics and potential pandemics.
Export Options
About this article
Cite this article as:
Cairns J. Murray, Small Interfering RNAs and their Therapeutic Applications in Mitigation of Virus Replication and Pathological Effects in the Respiratory Tract, Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 2008; 7 (2) . https://dx.doi.org/10.2174/187152308784533177
DOI https://dx.doi.org/10.2174/187152308784533177 |
Print ISSN 1871-5230 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-614X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Chemical Aspects of Coumarin Compounds for the Prevention of Hepatocellular Carcinomas
Current Medicinal Chemistry - Anti-Cancer Agents Ischemic and Oxidative Damage to the Hypothalamus May Be Responsible for Heat Stroke
Current Neuropharmacology Ebola Virus: Current and Future Perspectives
Infectious Disorders - Drug Targets COVID-19: Underpinning Research for Detection, Therapeutics, and Vaccines Development
Pharmaceutical Nanotechnology Anti-Inflammatory Role of Fetuin-A in Injury and Infection
Current Molecular Medicine Targeting Inflammation in Cancer-Related-Fatigue: A Rationale for Mistletoe Therapy as Supportive Care in Colorectal Cancer Patients
Inflammation & Allergy - Drug Targets (Discontinued) Immunomics in Skin Cancer - Improvement in Diagnosis, Prognosis and Therapy Monitoring
Current Proteomics Vascular Remodelling and Angiogenesis in Asthma: Morphological Aspects and Pharmacological Modulation
Inflammation & Allergy - Drug Targets (Discontinued) Synthetic Sustained Gene Delivery Systems
Current Topics in Medicinal Chemistry Depression has a Strong Relationship to Alterations in the Immune, Endocrine and Neural System
Current Psychiatry Reviews Oxidative Stress and Antioxidants in Neurological Diseases: Is There Still Hope?
Current Drug Targets Endogenous and Exogenous Ligands of Aryl Hydrocarbon Receptor: Current State of Art
Current Drug Metabolism Osteocyte biology and space flight
Current Biotechnology Molecular Mechanism of Anti-tumor Effect by Triptolide in Hematological Malignancies
Current Signal Transduction Therapy Uncovering γ-Secretase
Current Alzheimer Research Enhancement by Nanogold of the Efficacy of a Light-Activated Antimicrobial Coating
Current Nanoscience Swimming Impacts on Pancreatic Inflammatory Cytokines, miR-146a and NF-кB Expression Levels in Type-2 Diabetic Rats
Current Diabetes Reviews Neuroprotective Effects of Lutein in the Retina
Current Pharmaceutical Design Creating Chemical Diversity to Target Protein Kinases
Combinatorial Chemistry & High Throughput Screening Synthesis and Theoretical Calculations of 5-Aminosalicylic Acid Derivatives as Potential Analgesic Agents
Medicinal Chemistry