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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Chiral NADH Model: Design, Synthesis, Asymmetric Reduction Reaction, and Fluorescence Characteristics

Author(s): Cui-Bing Bai, Lei-Yang Zhang, Nai-Xing Wang*, Zhan Yan, Yue-Hua Wu, Bao-Cai Xu*, Ning Liu, Bo-Zhou Wang* and Vesna Tomasic

Volume 19, Issue 10, 2022

Published on: 25 March, 2022

Page: [827 - 831] Pages: 5

DOI: 10.2174/1570178619666220127122333

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Abstract

A new type of NADH model compound, which has six asymmetric carbon centers, has been synthesized by an efficient and convenient method. We used NADH models combined with enzymes in the asymmetric reduction. It was the first time that dehydrogenase combined with NADH models instead of inorganic catalysts, such as MgCl2, was used in the asymmetric reduction. Furthermore, the experimental results showed that the new NADH model has the strongest fluorescence emission properties compared to previously reported models.

Keywords: NADH model, synthesis, dehydrogenase, asymmetric reduction, fluorescence, NADH.

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