Functional Connectivity, Physical Activity, and Neurocognitive Performances
in Patients with Vascular Cognitive Impairment, No Dementia

doi:10.2174/1567205019666220127103852

摘要

背景：血管性认知障碍，无痴呆（VCIND）是早期干预延迟或预防痴呆的关键阶段。 VCIND 的病理生理学认为，大脑中单个位置的病变具有破坏大脑网络的能力，随后大脑网络的异常功能连接 (FC) 会导致相应神经行为域的缺陷。在这项研究中，我们检验了破坏前扣带皮层和纹状体网络介导体育活动 (PA) 对神经行为功能影响的假设。方法：在 27 名 VCIND 患者中，评估了脑网络内的 FC 和神经行为功能障碍。研究了认知评分、FC 和 PA 之间的关系。 Fitbit Charge 2 用于测量步数、距离和燃烧的卡路里。在 VCIND 患者中，使用横断面 Spearman 相关性分析患者级别的 PA、认知功能评分和脑网络内 FC 强度之间的关系。结果：平均步数和平均距离与 Trail Making Test B (TMB) 完成时间（秒）和日常生活工具活动 (IADL) 得分相关（P < 0.05）。燃烧的平均卡路里与 IADL 评分相关（P = 0.009）。由左尾前扣带皮层 (ACC) 种子 (x= -5, y= 0, z= 36) 和 (x= -5, y= -10, z= 47) 锚定的大脑网络内的 FC 呈正相关与平均步数和平均距离呈负相关，与 TMB 完成时间（秒）呈负相关，与 IADL 评分呈正相关（P < 0.05）。左膝下 ACC 种子 (x= -5, y= 25, z= -10) 锚定的大脑网络内的 FC 与平均步数呈负相关，平均距离与 TMB 完成时间（秒）呈正相关，并且与 IADL 评分呈负相关（P < 0.05）。纹状体网络内的 FC 与平均燃烧卡路里和 IADL 评分呈正相关（P < 0.05）。结论：尾部 ACC 种子锚定的脑网络内 FC 与更多的平均步数/平均距离和更好的 IADL 评分呈正相关；与较长的TMB完成时间（秒）呈负相关，而亚属ACC种子的FC与相同的参数呈负相关。由壳核而非尾状核或苍白球锚定的大脑网络内的 FC 与平均燃烧卡路里和 IADL 评分呈正相关。

关键词: 活动记录、大脑网络、认知、执行功能、功能连接、身体活动

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DOI https://dx.doi.org/10.2174/1567205019666220127103852	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828

当代阿耳茨海默病研究

血管性认知障碍、无痴呆症患者的功能连接、身体活动和神经认知表现

摘要

当代阿耳茨海默病研究

血管性认知障碍、无痴呆症患者的功能连接、身体活动和神经认知表现

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