Abstract
Family C of the superfamily of G-protein coupled receptors is a growing family of heptahelical receptors, which includes, among others, metabotropic glutamate receptors (mGluRs) and GABA(B) receptors. A common feature of all the members of family C is a structural architecture much more complex than any other GPCRs. Computational studies, including homology modeling, pharmacophore definitions and molecular dynamics simulations have constantly flanked experimental approaches in the understanding of the receptor functioning. The present review will discuss the evolution of our perception in family C GPCRs structure and function as emerged from the critical comparison of in silico methods with molecular biology and crystallographic experiments.
Keywords: GPCRs, Metabotropic glutamate receptors, Venus flytrap, homology modeling, Extracellular domain
Current Pharmaceutical Design
Title: In Silico Approaches Towards the Understanding of the Structure- Function Relationships in Metabotropic Glutamate Receptors (mGluRs) and other Family C GPRCs
Volume: 12 Issue: 17
Author(s): Gabriele Costantino
Affiliation:
Keywords: GPCRs, Metabotropic glutamate receptors, Venus flytrap, homology modeling, Extracellular domain
Abstract: Family C of the superfamily of G-protein coupled receptors is a growing family of heptahelical receptors, which includes, among others, metabotropic glutamate receptors (mGluRs) and GABA(B) receptors. A common feature of all the members of family C is a structural architecture much more complex than any other GPCRs. Computational studies, including homology modeling, pharmacophore definitions and molecular dynamics simulations have constantly flanked experimental approaches in the understanding of the receptor functioning. The present review will discuss the evolution of our perception in family C GPCRs structure and function as emerged from the critical comparison of in silico methods with molecular biology and crystallographic experiments.
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Cite this article as:
Costantino Gabriele, In Silico Approaches Towards the Understanding of the Structure- Function Relationships in Metabotropic Glutamate Receptors (mGluRs) and other Family C GPRCs, Current Pharmaceutical Design 2006; 12 (17) . https://dx.doi.org/10.2174/138161206777585210
DOI https://dx.doi.org/10.2174/138161206777585210 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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