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Recent Patents on Anti-Cancer Drug Discovery

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ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

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Mini-Review Article

Potential Therapeutic Application of Local Anesthetics in Cancer Treatment

Author(s): Zhaosheng Jin, William Zhang, Hengrui Liu, Arianna Ding, Yongjian Lin, Shao-Xiong Wu* and Jun Lin*

Volume 17, Issue 4, 2022

Published on: 30 March, 2022

Page: [326 - 342] Pages: 17

DOI: 10.2174/1574892817666220119121204

Price: $65

Abstract

Local anesthetics are voltage-gated sodium channel blockers primarily administered locally or to the innervating nerves for anesthetic or analgesic purposes. In vitro studies have found direct effects of local anesthetics on cancer cells, such as impact on cancer cell proliferation, apoptosis, migration, invasion, and chemosensitivity, by multiple mechanisms. So far, in vivo evidence regarding the effect of local anesthetics on cancer cell lines is relatively lacking. Local and regional anesthesia administration has been reported to reduce postoperative pain and opioid use in cancer treatment. Additionally, regional anesthesia may reduce the perioperative stress response. However, the clinical therapeutic application of local anesthetics in cancer remains exploratory. In this review, we will discuss the direct and indirect effects of local anesthetics on cancer cells, and discuss the current evidence related to the use of local anesthetics in the treatment of cancer.

Keywords: Cancer, immunomodulation, ion channels, local anesthetics, opioids, pain, stress response.

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