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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

使用患者来源的类器官研究结直肠癌干细胞的新前景

卷 22, 期 3, 2022

发表于: 17 March, 2022

页: [195 - 208] 页: 14

弟呕挨: 10.2174/1568009622666220117124546

价格: $65

摘要

人类结直肠癌 (CRC) 患者衍生的类器官 (PDO) 是一个强大的离体平台，可直接评估分子改变和治疗对肿瘤细胞增殖、分化、对化疗的反应、肿瘤-微环境相互作用以及 CRC 其他方面的影响生物学。新一代测序研究表明，CRC 是一种具有多种不同亚型的高度异质性疾病。 PDO 是研究 CRC 的一种有前途的新工具，因为它们能够准确地概括其源肿瘤并因此再现这种异质性。本综述总结了 CRC PDO 在癌症干细胞 (CSC) 和癌症干细胞生态位研究中的最新进展。重点领域包括 PDO 与了解 CSC 相关旁分泌信号传导的相关性，识别 CSC 与肿瘤微环境之间的相互作用，以及模拟 CSC 驱动的对化疗和靶向治疗的耐药性。最后，我们总结了有关使用 PDO 识别和验证 CSC 目标及其在个性化医疗中的潜在用途的当前发现。

关键词: 结直肠癌、癌症干细胞、肿瘤微环境、患者来源的类器官、个性化医疗、LGR5。

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