摘要
背景:卵巢癌是最具侵袭性的妇科癌症之一。许多患者在诊断和随后的治疗后两年内复发。在人们普遍认为与癌症发生有关的不同基因变化中,TP53是卵巢癌中最常见的突变。 目的:我们的工作旨在分析不同比较的结果,根据卵巢癌患者的总生存期,TP53状态的测定和p53蛋白在肿瘤组织中的数量。 方法:对436例卵巢患者的资料进行分析和比较。提取的数据包括TP53突变状态、p53蛋白水平和总生存信息。p53蛋白水平依赖于TP53突变状态的值采用独立样本t检验进行比较。生存分析采用Kaplan- Meier图,使用log-rank检验检验统计学意义。 结果:我们没有发现肿瘤组织中TP53状态的测定或p53蛋白的含量与卵巢癌患者的总生存期之间有任何统计学上的显著相关性。 结论:在卵巢肿瘤中,TP53状态及p53蛋白含量的测定诊断价值有限。
关键词: 卵巢癌,肿瘤抑制因子,TP53, p53,患者生存,预后实验室参数。
Current Medicinal Chemistry
Title:Determination of Both TP53 Mutation Status and the Amount of p53 Protein has Limited Diagnostic Importance for Patients with Ovarian Cancer
Volume: 29 Issue: 24
关键词: 卵巢癌,肿瘤抑制因子,TP53, p53,患者生存,预后实验室参数。
摘要:
Background: Ovarian cancer is one of the most aggressive types of gynecologic cancers. Many patients have a relapse within two years after diagnosis and subsequent therapy. Among different genetic changes generally believed to be important for the development of cancer, TP53 is the most common mutation in the case of ovarian tumors.
Objective: Our work aims to analyze the outcomes of different comparisons based on the overall survival of ovarian cancer patients, the determination of TP53 status and the amount of p53 protein in tumor tissues.
Methods: We analyzed and compared a collective of 436 ovarian patients’ data. The extracted data include TP53 mutation status, p53 protein level and information on the overall survival. Values for p53 protein level in dependence of the TP53 mutation status were compared using the Independent Samples t-Test. Survival analyses were displayed by Kaplan- Meier plots, using the log-rank test to check for statistical significance.
Results: We have not found any statistically significant correlations between the determination of TP53 status or the amount of p53 protein in tumor tissues and the overall survival of ovarian cancer patients.
Conclusion: In ovarian tumors the determination of both the TP53 status as well as the p53 protein amount has only limited diagnostic importance.
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Cite this article as:
Determination of Both TP53 Mutation Status and the Amount of p53 Protein has Limited Diagnostic Importance for Patients with Ovarian Cancer, Current Medicinal Chemistry 2022; 29 (24) . https://dx.doi.org/10.2174/0929867329666220112141211
DOI https://dx.doi.org/10.2174/0929867329666220112141211 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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