Green and Efficient Synthesis of 1, 2, 4-Triazolidine-3-thiones using Guanidine Hydrochloride as a Recyclable Catalyst under the Aqueous Condition

Title:Green and Efficient Synthesis of 1, 2, 4-Triazolidine-3-thiones using Guanidine Hydrochloride as a Recyclable Catalyst under the Aqueous Condition

Volume: 19 Issue: 9

Author(s): Angad B. Barkule, Yatin U. Gadkari and Vikas N. Telvekar*

Affiliation:

• Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Mumbai 400019, India

Keywords: Aldehydes, guanidine hydrochloride, water, 1, 2, 4-trizolodine-3-thiones, synthesis, catalyst.

Abstract: A rapid and highly efficient methodology for the synthesis of 1, 2, 4-triazolidine-3-thiones derivatives has been developed in the presence of a catalytic amount of guanidine hydrochloride using water as a solvent. The reaction of thiosemicarbazide with different aryl aldehydes resulted in the formation of title compounds in good yields (85-95%) with a convenient reaction time (20-30 min). The key advantages of this approach include shorter reaction time, energy efficiency, easy work-up procedure, and wide substrate scope tolerance. Furthermore, the catalyst was recycled without significant loss of its catalytic activity.

Cite this article as:

Barkule B. Angad, Gadkari U. Yatin and Telvekar N. Vikas*, Green and Efficient Synthesis of 1, 2, 4-Triazolidine-3-thiones using Guanidine Hydrochloride as a Recyclable Catalyst under the Aqueous Condition, Letters in Organic Chemistry 2022; 19 (9) . https://dx.doi.org/10.2174/1570178619666220111110352