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Mini-Reviews in Organic Chemistry

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ISSN (Print): 1570-193X
ISSN (Online): 1875-6298

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Mini-Review Article

Review on Synthesis of (S)-5-Benzylpyrrolidine-2,4-dione Derivatives with Substitution at C-3 Position by Employing Functional Groups Interconversion

Author(s): Munirah Zulkifli, Noor Hidayah Pungot*, Noraishah Abdullah, Nur Ain Nabilah Ash’ari and Zurina Shaameri

Volume 19, Issue 6, 2022

Published on: 18 February, 2022

Page: [681 - 685] Pages: 5

DOI: 10.2174/1570193X19666220110121158

Price: $65

Abstract

5-benzylpyrrolidine-2,4-dione 9 are versatile scaffolds with a unique structural feature responsible for the diversity of its biological importance. Over the past years, many researchers have reported the synthesis of various bio-active (S)-5-benzylpyrrolidine-2,4-dione derivatives due to their simplicity yet exhibiting promising bioactivities. This review focuses on the synthesis of core structure 9 and its derivatives based on the substitution at carbon-3 position of (S)-5-benzylpyrrolidine- 2,4-dione 9. This review also reported the effective method for the synthesis of core structure 9 with a 98% yield. Biological evaluations of various prepared derivatives by various researchers were described.

Keywords: 5-benzylpyrrolidine-2, 4-dione, substitution, C-3 position, synthesis, biological activities, derivatives.

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