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Current Drug Metabolism

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ISSN (Print): 1389-2002
ISSN (Online): 1875-5453

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Pharmacokinetics-based Chronotherapy

Author(s): Danyi Lu, Zhigang Wang* and Baojian Wu*

Volume 23, Issue 1, 2022

Published on: 21 February, 2022

Page: [2 - 7] Pages: 6

DOI: 10.2174/1389200223666220106124218

Abstract

Dosing time-dependency of pharmacokinetics (or chronopharmacokinetics) has been long recognized. Studies in recent years have revealed that daily rhythmicity in expression of drug-metabolizing enzymes and transporters (DMETs) are key factors determining chronopharmacokinetics. In this article, we briefly summarize current knowledge with respect to circadian mechanisms of DMETs and discuss how rhythmic DMETs are translated to drug chronoeffects. More importantly, we present our perspectives on pharmacokinetics-based chronotherapy.

Keywords: Chronopharmacokinetics, chronotherapy, drug-metabolizing enzymes, drug transporters, circadian rhythms, chronopharmacology.

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