摘要
近年来,环丁基在药物设计领域的影响力越来越大。其独特的四元环结构不仅是生物医学候选材料合成的有用中间体,而且是药物设计和应用不可或缺的框架。环丁基药物按治疗领域大致分为肿瘤和癌症药物、神经系统药物、镇痛药、抗病毒药物和胃肠道药物。其中,含环丁基片段的铂类抗癌药物在治疗癌症方面取得了显著的成功,为更多环丁基药物的开发带来了新的希望。本文详细介绍了已上市或处于临床阶段的环丁基药物的结构类型、构效关系、靶点、作用机制等方面的研究进展,为新型含环丁基药物的发现和合成提供思路。
关键词: 环丁基药物、铂类、抗癌药物、抗癌、构效关系、获批药物、激酶抑制剂。
Current Medicinal Chemistry
Title:Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A Review on Cyclobutyl Drugs
Volume: 29 Issue: 23
关键词: 环丁基药物、铂类、抗癌药物、抗癌、构效关系、获批药物、激酶抑制剂。
摘要: In recent years, cyclobutyl has become more influential in the field of drug design. Its unique four-membered ring structure is not only a useful intermediate for the synthesis of biomedical candidate materials but also an indispensable framework for drug design and application. According to the therapeutic field, cyclobutyl drugs are roughly divided into tumor and cancer drugs, nervous system drugs, analgesics, antiviral drugs, and gastrointestinal drugs. Among them, platinum-based anticancer drugs containing cyclobutyl fragments have achieved remarkable success in the treatment of cancer, bringing new hope for the development of more cyclobutyl drugs. This article provides details of the research progress of the structure types, structure-activity relationships, targets, and mechanisms of cyclobutyl drugs that have been on the market or are in the clinical stage and provides ideas for the discovery and synthesis of novel cyclobutyl-containing drugs.
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Cite this article as:
Molecules Containing Cyclobutyl Fragments as Therapeutic Tools: A Review on Cyclobutyl Drugs, Current Medicinal Chemistry 2022; 29 (23) . https://dx.doi.org/10.2174/0929867329666220105120722
DOI https://dx.doi.org/10.2174/0929867329666220105120722 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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