The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer

doi:10.2174/1568009622666211231140623
摘要

三阴性乳腺癌（TNBC）是一种缺乏靶向治疗受体的乳腺癌亚型。因此，化疗是目前系统治疗的主要选择。然而，肿瘤干细胞（CSC，一个具有干细胞特征和肿瘤启动倾向的亚群）的富集促进了化疗耐药性和肿瘤发生，导致癌症复发。此外，化疗药物的毒副作用会降低患者的幸福感。天然产物，特别是来源于植物的化合物，具有治疗TNBC和通过抑制CSC信号通路靶向CSCs的潜力。本文回顾了6种有前景化合物的文献证据，包括萝卜硫素、姜黄素、染料木素、白藜芦醇、番茄红素和表没食子儿茶素-3-没食子酸酯。这些化合物已被证明能促进TNBC细胞的细胞周期阻滞和凋亡。它们还能抑制在转移中起重要作用的上皮-间充质转化（EMT）。此外，这些天然化合物已被发现可以抑制CSCs的重要通路，如NF-κ b、PI3K/Akt/mTOR、Notch 1、Wnt/β- catenin和YAP。对这些化合物进行的临床试验显示了不同程度的有效性。还总结了对某些人类群体中通常消费的化合物的流行病学案例控制研究。虽然体内和体外数据很有潜力，但还需要进一步的基础和临床调查。很可能，天然产品与其他药物联合使用可能在改善TNBC疗效和患者预后方面有很大潜力。
关键词: 乳腺癌，三阴性乳腺癌，癌症干细胞，转移，凋亡，天然化合物。
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图形摘要

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DOI https://dx.doi.org/10.2174/1568009622666211231140623	Print ISSN 1568-0096
Publisher Name Bentham Science Publisher	Online ISSN 1873-5576
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