Abstract
Alzheimer’s disease (AD) was first identified more than 100 years ago, yet aspects pertaining to its origin and the mechanisms underlying disease progression are not well known. To this date, there is no therapeutic approach or disease-modifying drug that could halt or at least delay disease progression. Until recently, glial cells were seen as secondary actors in brain homeostasis. Although this view was gradually refuted and the relevance of glial cells for the most diverse brain functions such as synaptic plasticity and neurotransmission was vastly proved, many aspects of its functioning, as well as its role in pathological conditions, remain poorly understood. Metabotropic glutamate receptors (mGluRs) in glial cells were shown to be involved in neuroinflammation and neurotoxicity. Besides its relevance for glial function, glutamatergic receptors are also central in the pathology of AD, and recent studies have shown that glial mGluRs play a role in the establishment and progression of AD. AD-related alterations in Ca2+ signalling, APP processing, and Aβ load, as well as AD-related neurodegeneration, are influenced by glial mGluRs. However, different types of mGluRs play different roles, depending on the cell type and brain region that is being analysed. Therefore, in this review, we focus on the current understanding of glial mGluRs and their implication in AD, providing an insight for future therapeutics and identifying existing research gaps worth investigating.
Keywords: Alzheimer's disease, Metabotropic glutamate receptors, Astrocytes, Microglia, Neurodegeneration, Calcium signalling, Amyloid-beta
Graphical Abstract
[http://dx.doi.org/10.1002/ca.980080612] [PMID: 8713166]
[http://dx.doi.org/10.1016/j.jalz.2013.02.003] [PMID: 23507120]
[http://dx.doi.org/10.1192/bjp.bp.114.148403] [PMID: 27491532]
[http://dx.doi.org/10.1016/B978-0-444-64012-3.00002-2] [PMID: 31727229]
[http://dx.doi.org/10.1016/S0072-9752(07)01219-5] [PMID: 18631745]
[http://dx.doi.org/10.1016/S0006-291X(84)80190-4] [PMID: 6375662]
[http://dx.doi.org/10.1073/pnas.82.12.4245] [PMID: 3159021]
[http://dx.doi.org/10.1002/j.1460-2075.1985.tb04000.x] [PMID: 4065091]
[http://dx.doi.org/10.1073/pnas.83.13.4913] [PMID: 3088567]
[http://dx.doi.org/10.1073/pnas.83.11.4044] [PMID: 2424016]
[http://dx.doi.org/10.1016/S0021-9258(17)38495-8] [PMID: 3084478]
[http://dx.doi.org/10.1093/oxfordjournals.jbchem.a135625] [PMID: 2423512]
[http://dx.doi.org/10.1007/BF01182672] [PMID: 4781784]
[http://dx.doi.org/10.1007/BF00687139] [PMID: 3376753]
[http://dx.doi.org/10.1016/0022-510X(81)90048-4] [PMID: 7229656]
[http://dx.doi.org/10.1016/0022-510X(87)90057-8] [PMID: 3572454]
[http://dx.doi.org/10.1093/brain/awm112] [PMID: 17533169]
[http://dx.doi.org/10.1093/cercor/bhn111] [PMID: 18632740]
[http://dx.doi.org/10.1093/hmg/ddx381] [PMID: 29040533]
[http://dx.doi.org/10.1093/brain/awy079] [PMID: 29608645]
[http://dx.doi.org/10.1093/brain/awy188] [PMID: 30052812]
[http://dx.doi.org/10.1155/2006/276239] [PMID: 16410654]
[http://dx.doi.org/10.1002/glia.20967] [PMID: 20140958]
[http://dx.doi.org/10.1016/j.neurobiolaging.2005.09.012] [PMID: 16289476]
[http://dx.doi.org/10.1016/0165-5728(89)90115-X] [PMID: 2808689]
[http://dx.doi.org/10.1016/0304-3940(94)90121-X] [PMID: 7970158]
[http://dx.doi.org/10.1097/NEN.0b013e3182933788] [PMID: 23656989]
[PMID: 25815299]
[http://dx.doi.org/10.1126/science.1566067] [PMID: 1566067]
[http://dx.doi.org/10.1038/nn.4017] [PMID: 26007212]
[http://dx.doi.org/10.1038/325733a0] [PMID: 2881207]
[http://dx.doi.org/10.1016/S0304-4165(99)00140-3] [PMID: 10572956]
[http://dx.doi.org/10.1002/j.1460-2075.1988.tb02900.x] [PMID: 2900137]
[http://dx.doi.org/10.1126/science.1738846] [PMID: 1738846]
[http://dx.doi.org/10.1002/jnr.10737] [PMID: 14598310]
[http://dx.doi.org/10.1126/science.2111583] [PMID: 2111583]
[http://dx.doi.org/10.1126/science.286.5440.735] [PMID: 10531052]
[http://dx.doi.org/10.1021/bi026888g] [PMID: 12515548]
[http://dx.doi.org/10.1038/990107] [PMID: 10591213]
[http://dx.doi.org/10.1038/990114] [PMID: 10591214]
[http://dx.doi.org/10.1038/35024009] [PMID: 10993067]
[http://dx.doi.org/10.1016/S1534-5807(02)00189-2] [PMID: 12110170]
[http://dx.doi.org/10.1016/S0896-6273(03)00205-8] [PMID: 12691659]
[http://dx.doi.org/10.1002/jnr.10736] [PMID: 14598311]
[http://dx.doi.org/10.1097/00005072-199311000-00006] [PMID: 8229078]
[http://dx.doi.org/10.15252/emmm.201606210] [PMID: 27025652]
[http://dx.doi.org/10.1016/S1474-4422(12)70227-2] [PMID: 23137949]
[http://dx.doi.org/10.1016/S1474-4422(13)70044-9] [PMID: 23477989]
[http://dx.doi.org/10.1056/NEJMoa1202753] [PMID: 22784036]
[http://dx.doi.org/10.1002/ana.410300410] [PMID: 1789684]
[http://dx.doi.org/10.1177/0891988706291079] [PMID: 16880353]
[http://dx.doi.org/10.1126/science.1072994] [PMID: 12130773]
[http://dx.doi.org/10.1073/pnas.72.5.1858] [PMID: 1057175]
[http://dx.doi.org/10.1126/science.aat1780] [PMID: 29748322]
[http://dx.doi.org/10.1073/pnas.73.11.4070] [PMID: 1069293]
[http://dx.doi.org/10.1073/pnas.1504081112] [PMID: 26034266]
[http://dx.doi.org/10.1016/j.pneurobio.2018.12.005] [PMID: 30605723]
[http://dx.doi.org/10.1016/j.neurobiolaging.2011.01.005] [PMID: 21388709]
[http://dx.doi.org/10.1091/mbc.10.3.727] [PMID: 10069814]
[http://dx.doi.org/10.1074/jbc.M110.199976] [PMID: 21131359]
[http://dx.doi.org/10.1073/pnas.83.11.4040] [PMID: 2424015]
[http://dx.doi.org/10.1126/science.1062097] [PMID: 11520988]
[http://dx.doi.org/10.1126/science.1058189] [PMID: 11520987]
[http://dx.doi.org/10.1016/j.neuron.2004.07.003] [PMID: 15294141]
[http://dx.doi.org/10.1126/science.1141736] [PMID: 17478722]
[http://dx.doi.org/10.1016/j.neuron.2013.06.036] [PMID: 24012003]
[http://dx.doi.org/10.1038/nature07761] [PMID: 19242475]
[http://dx.doi.org/10.1038/nn.3178] [PMID: 22820466]
[http://dx.doi.org/10.1074/jbc.M607483200] [PMID: 17308309]
[http://dx.doi.org/10.1016/j.cell.2010.06.036] [PMID: 20655099]
[http://dx.doi.org/10.3233/JAD-160763] [PMID: 27662322]
[http://dx.doi.org/10.1073/pnas.1212971110] [PMID: 23277569]
[http://dx.doi.org/10.1126/science.1074069] [PMID: 12399581]
[http://dx.doi.org/10.1097/00005072-199708000-00011] [PMID: 9258263]
[http://dx.doi.org/10.1097/00005072-200606000-00007] [PMID: 16783169]
[http://dx.doi.org/10.1126/science.aad8373] [PMID: 27033548]
[http://dx.doi.org/10.1007/s12035-019-1467-8] [PMID: 30652266]
[http://dx.doi.org/10.2174/1566524015666150330143008] [PMID: 25817855]
[http://dx.doi.org/10.1016/0896-6273(94)90043-4] [PMID: 7946343]
[http://dx.doi.org/10.1038/s41582-020-00435-y] [PMID: 33318676]
[http://dx.doi.org/10.1002/glia.20783] [PMID: 18816644]
[http://dx.doi.org/10.1074/jbc.M806139200] [PMID: 19364772]
[http://dx.doi.org/10.1089/neu.2012.2589] [PMID: 23199080]
[http://dx.doi.org/10.1016/S0306-4522(01)00181-6] [PMID: 11672616]
[http://dx.doi.org/10.1093/jnen/63.8.831] [PMID: 15330338]
[http://dx.doi.org/10.1016/S0304-3940(99)00145-7] [PMID: 10213149]
[http://dx.doi.org/10.1002/(SICI)1097-4547(19991115)58:4<533::AID-JNR6>3.0.CO;2-G] [PMID: 10533045]
[http://dx.doi.org/10.1523/JNEUROSCI.15-09-06103.1995] [PMID: 7666194]
[http://dx.doi.org/10.1002/(SICI)1098-1136(199712)21:4<390::AID-GLIA6>3.0.CO;2-7] [PMID: 9419014]
[http://dx.doi.org/10.1023/A:1027317319166] [PMID: 9251103]
[http://dx.doi.org/10.1002/(SICI)1098-1136(20000101)29:1<70::AID-GLIA7>3.0.CO;2-V] [PMID: 10594924]
[http://dx.doi.org/10.1046/j.1471-4159.1999.721671.x] [PMID: 10098876]
[http://dx.doi.org/10.1126/science.1226740] [PMID: 23307741]
[http://dx.doi.org/10.1523/JNEUROSCI.1860-14.2014] [PMID: 25186741]
[http://dx.doi.org/10.1002/cne.903590206] [PMID: 7499528]
[http://dx.doi.org/10.1002/cne.903620108] [PMID: 8576426]
[http://dx.doi.org/10.1002/glia.22548] [PMID: 23922225]
[http://dx.doi.org/10.1038/cddis.2013.145] [PMID: 23661001]
[http://dx.doi.org/10.1016/j.brainres.2008.12.082] [PMID: 19401173]
[http://dx.doi.org/10.1002/glia.22502] [PMID: 23616440]
[http://dx.doi.org/10.1016/j.neurobiolaging.2012.05.005] [PMID: 22673114]
[http://dx.doi.org/10.1016/j.ceca.2014.02.016] [PMID: 24656753]
[http://dx.doi.org/10.1046/j.1471-4159.2002.01062.x] [PMID: 12358765]
[http://dx.doi.org/10.1016/j.neuropharm.2017.05.008] [PMID: 28495373]
[http://dx.doi.org/10.1523/JNEUROSCI.4456-04.2005] [PMID: 15772355]
[http://dx.doi.org/10.1002/cne.903350209] [PMID: 8227517]
[http://dx.doi.org/10.1016/j.brainres.2007.02.041] [PMID: 17428452]
[http://dx.doi.org/10.1016/S0304-3940(99)00484-X] [PMID: 10462106]
[http://dx.doi.org/10.1016/j.neuropharm.2013.11.015] [PMID: 24291464]
[http://dx.doi.org/10.1016/j.neuint.2019.104547] [PMID: 31536785]
[http://dx.doi.org/10.1124/mol.110.067488] [PMID: 21159998]
[http://dx.doi.org/10.1523/JNEUROSCI.22-13-05403.2002] [PMID: 12097492]
[http://dx.doi.org/10.1523/JNEUROSCI.23-06-02150.2003] [PMID: 12657674]
[http://dx.doi.org/10.1016/S0166-4328(02)00272-3] [PMID: 12644276]
[PMID: 10049997]
[http://dx.doi.org/10.1146/annurev.pharmtox.37.1.205] [PMID: 9131252]
[PMID: 7724653]
[http://dx.doi.org/10.1146/annurev.pharmtox.011008.145533] [PMID: 20055706]
[http://dx.doi.org/10.1016/S0163-7258(03)00038-X] [PMID: 12782243]
[http://dx.doi.org/10.1016/j.coph.2006.08.008] [PMID: 17055336]
[http://dx.doi.org/10.1042/bj3590465] [PMID: 11672421]
[http://dx.doi.org/10.1038/7243] [PMID: 10204539]
[http://dx.doi.org/10.1523/JNEUROSCI.5355-08.2009] [PMID: 19403827]
[http://dx.doi.org/10.1093/cercor/bhm193] [PMID: 18024992]
[http://dx.doi.org/10.1016/0092-8674(94)90204-6] [PMID: 7954802]
[http://dx.doi.org/10.1523/JNEUROSCI.21-16-05925.2001] [PMID: 11487615]
[http://dx.doi.org/10.3389/fphar.2012.00189] [PMID: 23125836]
[http://dx.doi.org/10.1038/nn1134] [PMID: 14528310]
[http://dx.doi.org/10.1038/ncomms13571] [PMID: 27886171]
[http://dx.doi.org/10.1016/j.phrs.2016.11.013] [PMID: 27872019]
[http://dx.doi.org/10.1016/0896-6273(93)90086-7] [PMID: 8104433]
[http://dx.doi.org/10.1111/j.1460-9568.1996.tb01611.x] [PMID: 8758956]
[http://dx.doi.org/10.1016/0896-6273(92)90165-A] [PMID: 1323311]
[http://dx.doi.org/10.1002/cne.903550310] [PMID: 7636025]
[http://dx.doi.org/10.1523/JNEUROSCI.17-19-07503.1997] [PMID: 9295396]
[http://dx.doi.org/10.1016/0304-3940(93)90227-C] [PMID: 8295733]
[http://dx.doi.org/10.1093/brain/awg179] [PMID: 12805104]
[http://dx.doi.org/10.1016/j.expneurol.2005.05.012] [PMID: 16004983]
[http://dx.doi.org/10.2174/1567205011666140812115423] [PMID: 25115540]
[http://dx.doi.org/10.1523/JNEUROSCI.17-20-07817.1997] [PMID: 9315902]
[http://dx.doi.org/10.1186/1756-6606-6-9] [PMID: 23406666]
[http://dx.doi.org/10.1046/j.1471-4159.1999.721441.x] [PMID: 10098847]
[http://dx.doi.org/10.1046/j.1471-4159.1998.71020603.x] [PMID: 9681450]
[PMID: 11561058]
[http://dx.doi.org/10.1085/jgp.109.4.477] [PMID: 9101406]
[http://dx.doi.org/10.1111/j.1471-4159.1993.tb09796.x] [PMID: 7693864]
[http://dx.doi.org/10.1523/JNEUROSCI.18-23-09594.1998] [PMID: 9822720]
[http://dx.doi.org/10.1046/j.1471-4159.2001.00435.x] [PMID: 11483646]
[http://dx.doi.org/10.1046/j.1460-9568.2003.02657.x] [PMID: 12786977]
[http://dx.doi.org/10.1124/mol.106.031617] [PMID: 17293559]
[http://dx.doi.org/10.1016/S0197-0186(00)00019-X] [PMID: 10812201]
[http://dx.doi.org/10.1111/j.1471-4159.2004.02937.x] [PMID: 15686497]
[http://dx.doi.org/10.1002/jnr.20897] [PMID: 16752416]
[http://dx.doi.org/10.1002/(SICI)1098-1136(199909)27:3<275::AID-GLIA9>3.0.CO;2-0] [PMID: 10457374]
[http://dx.doi.org/10.1046/j.1471-4159.2001.00056.x] [PMID: 11208898]
[http://dx.doi.org/10.1101/cshperspect.a035188] [PMID: 31110130]
[http://dx.doi.org/10.1152/physrev.00042.2016] [PMID: 29351512]
[http://dx.doi.org/10.1016/S0166-2236(98)01349-6] [PMID: 10322493]
[http://dx.doi.org/10.1523/JNEUROSCI.16-21-06908.1996] [PMID: 8824329]
[http://dx.doi.org/10.1002/glia.1061] [PMID: 11360300]
[http://dx.doi.org/10.1126/scitranslmed.3003748] [PMID: 22896675]
[http://dx.doi.org/10.1126/science.1240514] [PMID: 23812703]
[http://dx.doi.org/10.1038/nrneurol.2015.119] [PMID: 26195256]
[http://dx.doi.org/10.1002/ana.24271] [PMID: 25204284]
[http://dx.doi.org/10.1186/1742-2094-2-22] [PMID: 16212664]
[http://dx.doi.org/10.1042/AN20110025] [PMID: 22103264]
[http://dx.doi.org/10.2967/jnumed.110.087031] [PMID: 22213821]
[http://dx.doi.org/10.1093/brain/awv404] [PMID: 26813969]
[http://dx.doi.org/10.1177/1073858414547132] [PMID: 25125026]
[http://dx.doi.org/10.1038/cddis.2017.89] [PMID: 28333144]
[http://dx.doi.org/10.1074/jbc.M602440200] [PMID: 16787929]
[http://dx.doi.org/10.1523/JNEUROSCI.2085-06.2006] [PMID: 17065436]
[http://dx.doi.org/10.1096/fj.12-208660] [PMID: 23038755]
[http://dx.doi.org/10.1002/glia.22800] [PMID: 25731615]
[http://dx.doi.org/10.1097/00005072-199708000-00008] [PMID: 9258260]
[http://dx.doi.org/10.3233/JAD-2007-11113] [PMID: 17361039]
[http://dx.doi.org/10.1111/nan.12475] [PMID: 29405337]
[http://dx.doi.org/10.1002/ana.410400512] [PMID: 8957017]
[http://dx.doi.org/10.1038/ncomms13441] [PMID: 27834383]
[http://dx.doi.org/10.3233/JAD-2011-110503] [PMID: 21677376]
[http://dx.doi.org/10.1084/jem.20140413] [PMID: 25711212]
[http://dx.doi.org/10.1038/s41598-018-19442-7] [PMID: 29374250]
[http://dx.doi.org/10.1126/science.1110647] [PMID: 15831717]
[http://dx.doi.org/10.1002/1098-1136(200103)33:3<256::AID-GLIA1024>3.0.CO;2-J] [PMID: 11241743]
[http://dx.doi.org/10.1038/nn1472] [PMID: 15895084]
[http://dx.doi.org/10.1002/glia.10362] [PMID: 15042586]
[http://dx.doi.org/10.1016/j.arr.2016.07.002] [PMID: 27421577]
[http://dx.doi.org/10.1152/physrev.00011.2010] [PMID: 21527731]
[http://dx.doi.org/10.1016/j.cell.2013.11.030] [PMID: 24360280]
[http://dx.doi.org/10.1126/science.1202529] [PMID: 21778362]
[http://dx.doi.org/10.1016/S0896-6273(04)00069-8] [PMID: 14980203]
[http://dx.doi.org/10.1016/j.devcel.2012.10.027] [PMID: 23201120]
[http://dx.doi.org/10.1038/s41586-020-2777-8] [PMID: 32999463]
[http://dx.doi.org/10.1002/glia.10319] [PMID: 14730714]
[http://dx.doi.org/10.1002/glia.22287] [PMID: 22223464]
[http://dx.doi.org/10.1007/s00441-012-1537-y] [PMID: 23250575]
[http://dx.doi.org/10.3389/fnagi.2017.00194] [PMID: 28659790]
[http://dx.doi.org/10.1523/JNEUROSCI.21-04-01179.2001] [PMID: 11160388]
[http://dx.doi.org/10.1016/0006-8993(96)00156-4] [PMID: 8782901]
[http://dx.doi.org/10.1523/JNEUROSCI.17-07-02284.1997] [PMID: 9065490]
[http://dx.doi.org/10.1084/jem.20151948] [PMID: 27091843]
[http://dx.doi.org/10.1038/nn.4338] [PMID: 27459405]
[http://dx.doi.org/10.1038/s41583-018-0057-5] [PMID: 30206328]
[http://dx.doi.org/10.1016/j.cell.2017.05.018] [PMID: 28602351]
[http://dx.doi.org/10.1126/science.8346443] [PMID: 8346443]
[http://dx.doi.org/10.1056/NEJMoa1211103] [PMID: 23150908]
[http://dx.doi.org/10.1056/NEJMoa1211851] [PMID: 23150934]
[http://dx.doi.org/10.1016/j.neuron.2018.01.031] [PMID: 29518356]
[http://dx.doi.org/10.1016/j.neuron.2016.06.015] [PMID: 27477018]
[http://dx.doi.org/10.2353/ajpath.2010.100265] [PMID: 20864679]
[http://dx.doi.org/10.1074/jbc.272.46.29390] [PMID: 9361021]
[http://dx.doi.org/10.1016/j.neuron.2006.01.022] [PMID: 16476660]
[http://dx.doi.org/10.1016/j.febslet.2007.01.009] [PMID: 17240371]
[http://dx.doi.org/10.1186/1750-1326-6-45] [PMID: 21718498]
[http://dx.doi.org/10.1038/s41590-021-00913-5] [PMID: 33859405]
[http://dx.doi.org/10.1016/j.ajpath.2011.07.001] [PMID: 21835156]
[http://dx.doi.org/10.4049/jimmunol.0903382] [PMID: 20368278]
[http://dx.doi.org/10.1038/s41586-021-03734-6] [PMID: 34262178]
[http://dx.doi.org/10.1038/nature21029] [PMID: 28099414]
[http://dx.doi.org/10.1073/pnas.87.9.3454] [PMID: 1970637]
[http://dx.doi.org/10.1126/science.1967852] [PMID: 1967852]
[http://dx.doi.org/10.1038/90507] [PMID: 11477426]
[http://dx.doi.org/10.1038/nn1703] [PMID: 16699507]
[http://dx.doi.org/10.1016/0896-6273(91)90238-U] [PMID: 1675864]
[http://dx.doi.org/10.1016/0896-6273(92)90271-E] [PMID: 1347996]
[http://dx.doi.org/10.1038/5692] [PMID: 10195197]
[http://dx.doi.org/10.1016/j.neuron.2009.03.019] [PMID: 19447095]
[http://dx.doi.org/10.1038/nn.2557] [PMID: 20495558]
[http://dx.doi.org/10.1038/nn.4001] [PMID: 25894291]
[http://dx.doi.org/10.1016/j.jphs.2020.07.006] [PMID: 32709559]
[http://dx.doi.org/10.1016/j.neuron.2004.08.011] [PMID: 15339653]
[http://dx.doi.org/10.1523/JNEUROSCI.3965-04.2005] [PMID: 15745945]
[http://dx.doi.org/10.1073/pnas.0609408104] [PMID: 17259307]
[http://dx.doi.org/10.1523/JNEUROSCI.18-17-06822.1998] [PMID: 9712653]
[http://dx.doi.org/10.1523/JNEUROSCI.2859-03.2004] [PMID: 14736858]
[http://dx.doi.org/10.1126/science.1144640] [PMID: 17717185]
[http://dx.doi.org/10.1038/nn980] [PMID: 12469126]
[http://dx.doi.org/10.1038/nature02827] [PMID: 15356633]
[http://dx.doi.org/10.1038/nature07525] [PMID: 18971930]
[http://dx.doi.org/10.3389/fncel.2017.00427] [PMID: 29386997]
[http://dx.doi.org/10.1038/nn.4201] [PMID: 26814587]
[http://dx.doi.org/10.3389/fnmol.2018.00239] [PMID: 30057525]
[http://dx.doi.org/10.1523/JNEUROSCI.23-12-05088.2003] [PMID: 12832532]
[http://dx.doi.org/10.1126/science.1169096] [PMID: 19251629]
[http://dx.doi.org/10.1196/annals.1379.004] [PMID: 17413008]
[http://dx.doi.org/10.1016/S0304-3940(98)00106-2] [PMID: 9535128]
[http://dx.doi.org/10.1016/S0306-4522(98)00008-6] [PMID: 9681953]
[http://dx.doi.org/10.1016/j.neuron.2009.05.012] [PMID: 19555648]
[http://dx.doi.org/10.1002/glia.24006] [PMID: 34339538]
[http://dx.doi.org/10.1111/j.1474-9726.2011.00682.x] [PMID: 21272193]
[http://dx.doi.org/10.1042/BST20140163] [PMID: 25233403]
[http://dx.doi.org/10.1016/j.ceca.2010.09.004] [PMID: 20926134]
[http://dx.doi.org/10.1523/JNEUROSCI.13-04-01372.1993] [PMID: 8463825]
[http://dx.doi.org/10.1016/0896-6273(92)90118-W] [PMID: 1309649]
[http://dx.doi.org/10.1016/j.neuron.2014.02.041] [PMID: 24742463]
[http://dx.doi.org/10.1016/S0960-9822(03)00330-0] [PMID: 12747838]
[http://dx.doi.org/10.1038/s41593-020-0679-6] [PMID: 32747787]
[http://dx.doi.org/10.1111/j.1749-6632.1996.tb34443.x] [PMID: 8624110]
[http://dx.doi.org/10.1046/j.1471-4159.1997.68051830.x] [PMID: 9109507]
[http://dx.doi.org/10.1007/s11481-012-9427-3] [PMID: 23238794]
[http://dx.doi.org/10.1371/journal.pbio.0050052] [PMID: 17298186]
[http://dx.doi.org/10.1006/nbdi.2002.0506] [PMID: 12270684]
[http://dx.doi.org/10.1073/pnas.2014080117] [PMID: 32958647]
[http://dx.doi.org/10.3389/fnmol.2018.00414] [PMID: 30483053]
[http://dx.doi.org/10.1523/JNEUROSCI.17-06-01891.1997] [PMID: 9045718]
[http://dx.doi.org/10.1523/JNEUROSCI.1889-07.2007] [PMID: 17670976]
[http://dx.doi.org/10.1371/journal.pone.0022235] [PMID: 21779400]
[http://dx.doi.org/10.1016/j.neuint.2020.104837] [PMID: 32858088]
[http://dx.doi.org/10.1016/j.neuint.2019.03.020] [PMID: 30930274]
[http://dx.doi.org/10.1016/0014-5793(90)81408-G] [PMID: 2110534]
[http://dx.doi.org/10.1016/0304-3940(94)90227-5] [PMID: 8041489]
[http://dx.doi.org/10.1046/j.1471-4159.1999.0730538.x] [PMID: 10428049]