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Current Reviews in Clinical and Experimental Pharmacology

Editor-in-Chief

ISSN (Print): 2772-4328
ISSN (Online): 2772-4336

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Preface

Patient-Centricity: A Much-Needed Strategy to Enhance the Quality Use of Medicines in Older Patients

Author(s): Arduino A. Mangoni* and Elzbieta A. Jarmuzewska

Volume 17, Issue 1, 2022

Page: [1 - 2] Pages: 2

DOI: 10.2174/277243281701211223100004

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[1]
Gao L, Maidment I, Matthews FE, Robinson L, Brayne C. Medical Research Council Cognitive Function and Ageing Study. Medication usage change in older people (65+) in England over 20 years: findings from CFAS I and CFAS II. Age Ageing 2018; 47(2): 220-5.
[http://dx.doi.org/10.1093/ageing/afx158.]
[2]
Mangoni AA, Jansen PA, Jackson SH. Under-representation of older adults in pharmacokinetic and pharmacodynamic studies: a solvable problem? Expert Rev Clin Pharmacol 2013; 6: 35-9.
[http://dx.doi.org/10.1586/ecp.12.75.]
[3]
Bostock CV, Soiza RL, Mangoni AA. Association between prescribing of antimuscarinic drugs and antimuscarinic adverse effects in older people. Expert Rev Clin Pharmacol 2010; 3: 441-52.
[http://dx.doi.org/10.1586/ecp.10.34.]
[4]
Ruxton K, Woodman RJ, Mangoni AA. Drugs with anticholinergic effects and cognitive impairment, falls and all-cause mortality in older adults: A systematic review and meta-analysis. Br J Clin Pharmacol 2015; 80: 209-20.
[http://dx.doi.org/10.1111/bcp.12617.]
[5]
Maes ML, Fixen DR, Linnebur SA. Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence. Ther Adv Drug Saf 2017; 8: 273-97.
[http://dx.doi.org/10.1177/2042098617715381.]
[6]
Seppala LJ, Wermelink A, de Vries M, et al. Finish group on fall-risk-increasing d Fall-Risk-Increasing Drugs: A Systematic Review and Meta-Analysis: II Psychotropics J Am Med Dir Assoc 2018; 19: 371: e11-7.
[http://dx.doi.org/10.1016/j.jamda.2017.12.098.]
[7]
Seppala LJ, van de Glind EMM, Daams JG, et al. Finish Group on Fall-Risk-Increasing D. Fall-Risk-Increasing Drugs: A Systematic Review and Meta-analysis: III. Others. J Am Med Dir Assoc 2018; 19: 372: e1-8.
[http://dx.doi.org/10.1016/j.jamda.2017.12.099..]
[8]
Jackson SH, Jansen PA, Mangoni AA. Off-label prescribing in older patients. Drugs Aging 2012; 29: 427-34.
[http://dx.doi.org/10.2165/11633520-000000000-00000.]
[9]
Mangoni AA, Jackson SH. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004; 57: 6-14.
[10]
Reeve E, Wiese MD, Mangoni AA. Alterations in drug disposition in older adults. Expert Opin Drug Metab Toxicol 2015; 11: 491-508.
[http://dx.doi.org/10.1517/17425255.2015.1004310.]
[11]
Maher D, Ailabouni N, Mangoni AA, Wiese MD, Reeve E. Alterations in drug disposition in older adults: a focus on geriatric syndromes. Expert Opin Drug Metab Toxicol 2021; 17: 41-52.
[http://dx.doi.org/10.1080/17425255.2021.1839413.]
[12]
Tay HS, Soiza RL, Mangoni AA. Minimizing anticholinergic drug prescribing in older hospitalized patients: a full audit cycle. Ther Adv Drug Saf 2014; 5: 121-8.
[http://dx.doi.org/10.1177/2042098614523638.]
[13]
Wilsdon TD, Hendrix I, Thynne TR, Mangoni AA. Effectiveness of Interventions to Deprescribe Inappropriate Proton Pump Inhibitors in Older Adults. Drugs Aging 2017; 34: 265-87.
[http://dx.doi.org/10.1007/s40266-017-0442-1.]
[14]
Russell P, Hewage U, McDonald C, Thompson C, Woodman R, Mangoni AA. Prospective cohort study of nonspecific deprescribing in older medical inpatients being discharged to a nursing home. Ther Adv Drug Saf 2021; 12.
[http://dx.doi.org/10.1177/20420986211052344.]
[15]
Caughey GE, Inacio MC, Bell JS, Vitry AI, Shakib S. Inclusion of Older People Reflective of Real-World Clinical Practice in Cardiovascular Drug Trials. J Am Heart Assoc 2020; 9e016936
[http://dx.doi.org/10.1161/JAHA.120.016936.]
[16]
Ruiter R, Burggraaf J, Rissmann R. Under-representation of elderly in clinical trials: An analysis of the initial approval documents in the Food and Drug Administration database. Br J Clin Pharmacol 2019; 85: 838-44.
[http://dx.doi.org/10.1111/bcp.13876.]
[17]
Crome P, Lally F, Cherubini A, et al. Exclusion of older people from clinical trials: professional views from nine European countries participating in the predict study. Drugs Aging 2011; 28: 667-77.
[http://dx.doi.org/10.2165/11591990-000000000-00000.]
[18]
Hagege M, Canoui-Poitrine F, Derbez B. Including older patients in cancer trials: A qualitative study of collaboration between geriatricians and oncologists. J Geriatr Oncol 2021; 12: 945-51.
[http://dx.doi.org/10.1016/j.jgo.2021.03.002.]
[19]
Fialova D, Laffon B, Marinkovic V, et al. Medication use in older patients and age-blind approach: narrative literature review (insufficient evidence on the efficacy and safety of drugs in older age, frequent use of PIMs and polypharmacy, and underuse of highly beneficial nonpharmacological strategies). Eur J Clin Pharmacol 2019; 75: 451-66.
[http://dx.doi.org/10.1007/s00228-018-2603-5.]
[20]
Iersel TV, Courville J, Doorne CV, Koster RA, Fawcett C. The patient motivation pyramid and patient-centricity in early clinical development. Curr Rev Clin Exp Pharmacol 2021.
[http://dx.doi.org/10.2174/1574884716666210427115820.]
[21]
Bostock CV, Soiza RL, Mangoni AA. Associations between different measures of anticholinergic drug exposure and Barthel Index in older hospitalized patients. Ther Adv Drug Saf 2013; 4: 235-45.
[http://dx.doi.org/10.1177/2042098613500689.]
[22]
Wouters H, Hilmer SN, Twisk J, et al. Drug burden index and cognitive and physical function in aged care residents: A longitudinal study. J Am Med Dir Assoc 2020; 21: 1086-92. e1
[http://dx.doi.org/10.1016/j.jamda.2020.05.037.]
[23]
Mangoni AA, Pilotto A. New drugs and patient-centred end-points in old age: setting the wheels in motion Expert Rev Clin Pharmacol 2016; 9: 81-9.
[http://dx.doi.org/10.1586/17512433.2016.1100074.]

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