摘要
纳米技术因其巨大的治疗和诊断潜力已被广泛利在管理多种疾病。它采用纳米材料作为药物载体,增强了对正常组织的疗效,减少了副作用。许多纳米材料已经被研究和生产出来,这将立即改变包括癌症在内的许多恶性肿瘤的治疗和诊断。本研究的目的是探讨基于纳米技术的设备/疗法在癌症治疗和诊断中具有重要作用,并在三个层面上产生潜在影响:早期检测、肿瘤成像和药物传递方法。专注于癌症,除了早期识别恶性和癌前病变外,基于纳米技术的有前景的方法已被规划以满足对传统化疗药物靶向特异性的需求。前列腺癌是世界上第五大最著名的癌症,也是第二大最常在男性中发现的癌症。因此,利用纳米材料在细胞靶向特异性方面的潜力,提高癌前肿瘤的初步诊断水平,对改善前列腺癌的诊断和治疗有着至关重要的需求。因此,本文重点综述了纳米技术在前列腺癌预后和诊断方面的所有前瞻性应用,这将进一步帮助研究人员阐明一种更有效的治疗方法,以更好地治疗前列腺癌。
关键词: 癌细胞,前列腺癌,细胞毒性,纳米颗粒,靶向传递,药物传递。
Current Medicinal Chemistry
Title:Nanoparticles Mediated Target-specific Drug Delivery in Prostate Cancer: An In-depth Review
Volume: 29 Issue: 24
关键词: 癌细胞,前列腺癌,细胞毒性,纳米颗粒,靶向传递,药物传递。
摘要: Nanotechnology has been extensively exploited for its enormous therapeutic and diagnostic potential in the management of multiple disorders. It employs nanomaterials as drug carriers with enhanced efficacy and limited side effects on normal tissues. A lot of nanomaterials have been studied and produced, imminently reforming the treatment and diagnostics of numerous malignancies, including cancer. The purpose of the present study is to explore the role of nanotechnology-based devices/therapies that have a vital function in the therapeutics and diagnostics of cancer with potential impact at three levels: early detection, tumor imaging, and drug delivery methods. Concentrating on cancer, promising nanotechnology-based approaches have been planned to satisfy the need for targeted specificity of traditional agents of chemotherapeutics, in addition to early recognition of malignant and precancerous lesions. Prostate cancer is the fifth most wellknown cancer worldwide and the second most usually detected cancer in men. Therefore, there is a crucial need to improve therapeutic prospects for the diagnosis and treatment of prostate cancer via the exploitation of the potential of nanomaterials for cell-targeted specificity and improved primary diagnosis of precancerous tumors. The present review, therefore, focuses on summarizing all prospective applications of nanotechnology in the prognosis and diagnosis of prostate cancer, which would further help researchers to elucidate a more potent therapeutic approach for the better management of prostate cancer in the days ahead.
Export Options
About this article
Cite this article as:
Nanoparticles Mediated Target-specific Drug Delivery in Prostate Cancer: An In-depth Review, Current Medicinal Chemistry 2022; 29 (24) . https://dx.doi.org/10.2174/0929867329666211221112312
DOI https://dx.doi.org/10.2174/0929867329666211221112312 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
siRNA-Mediated Knock-Down of P-Glycoprotein Expression Reveals Distinct Cellular Disposition of Anticancer Tyrosine Kinases Inhibitors
Drug Metabolism Letters Nanotechnology as an Adjunct Tool for Transplanting Engineered Cells and Tissues
Current Molecular Medicine Lacticin LC14, a New Bacteriocin Produced by Lactococcus lactis BMG6.14: Isolation, Purification and Partial Characterization
Infectious Disorders - Drug Targets Biomarkers of Oxidative Stress in the Assessment of Enantioselective Toxicity of Chiral Pesticides
Current Protein & Peptide Science Exploring Novel Immunological Interventions Using Immunoinfectomics
Anti-Infective Agents A New Synthesis of Poly Heterocyclic Compounds Containing [1,2,4]triazolo and [1,2,3,4]tetrazolo Moieties and their DFT Study as Expected Anti-cancer Reagents
Current Organic Synthesis Diversity and Variability of the Effects of Nicotine on Different Cortical Regions of the Brain. Therapeutic and Toxicological Implications
Central Nervous System Agents in Medicinal Chemistry TEMPO (2,2,6,6-tetramethylpiperidine-N-oxyl) an Important Reagent in Alcohol Oxidation and its Application in Synthesis of Natural Products
Mini-Reviews in Organic Chemistry Prediction of Activities of BRAF (V600E) Inhibitors by SW-MLR and GA-MLR Methods
Current Computer-Aided Drug Design The Synthesis and Evaluation of Novel Lactate Dehydrogenase Nanobioconjugates
Current Nanoscience Development of Polymeric Nanocarriers for Brain Targeted Delivery of Atorvastatin: A Quality-By-Design Approach
Drug Delivery Letters Hydroxytyrosol and Derivatives: Isolation, Synthesis, and Biological Properties
Current Organic Chemistry Targeting Intestinal Transporters for Optimizing Oral Drug Absorption
Current Drug Metabolism Cannabis sativa L. Constituents and Their Role in Neuroinflammation
Current Bioactive Compounds Maps of cis-Regulatory Nodes in Megabase Long Genome Segments are an Inevitable Intermediate Step Toward Whole Genome Functional Mapping
Current Genomics Bis (Isothiocyanatomethyl) Benzene, A Plant Derived Anti-Neoplastic Compound: Purified from Moringa Oleifera Leaf Extract
Anti-Cancer Agents in Medicinal Chemistry Enhancing Oral Bioavailability of Methylnaltrexone Using an Emulsion Formulation
Letters in Drug Design & Discovery Structural Patterning Used for Polyfunctional Devices in Diagnostics and for the Delivery of Therapeutics
Recent Patents on Materials Science Novel 5-Methyl-2,4-Disubstitued-Oxazole Derivatives: Synthesis and Anticancer Activity
Letters in Drug Design & Discovery NF-κB Down–regulation and PARP Cleavage by novel 3-α-butyryloxy-β-boswellic Acid Results in Cancer Cell Specific Apoptosis and in vivo Tumor Regression
Anti-Cancer Agents in Medicinal Chemistry