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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

β-Dihydroagarofuran-type Sesquiterpenoids from the Stems of Celastrus orbiculatus with their Cytotoxic Activities

Author(s): Yong Hua Lin*, Bao Yan Zhang, Zhi Chao Chen and Jian Feng Wei

Volume 19, Issue 9, 2022

Published on: 01 March, 2022

Page: [770 - 773] Pages: 4

DOI: 10.2174/1570178619666211220101500

Price: $65

Abstract

A new β-dihydroagarofuran-type sesquiterpenoid named 1α,2α,5α,11-tetraacetoxy-8α- (trans-p-coumaroyl)-β-dihydroagarofuran (1), together with five known compounds (2-6), was isolated from the CHCl3-soluble extract of the stems of Celastrus orbiculatus. The structure of the new compound was elucidated with spectroscopic physicochemical analyses. All isolates were evaluated for in vitro cytotoxic activity against four human cancer lines, including HepG2, MCF-7, A549, and HCT-116 cells. Among them, compounds 1 and 6 showed potent cytotoxic activities against HepG2 cells with IC50 values of 8.78 ± 2.31 and 10.28 ± 1.15 μM, respectively. In addition, compound 6 exhibited significant cytotoxic activity against HCT-116 cells with an IC50 value of 6.37 ± 2.52 μM.

Keywords: Celastrus orbiculatus, celastraceae, Chinese traditional medicine, sesquiterpenoids, cytotoxic activity, structureactivity relationships.

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