痴呆症的可改变风险因素：肠道微生物群的作用

Title:Modifiable Risk Factors for Dementia: The Role of Gut Microbiota

Volume: 18 Issue: 13

关键词: 痴呆症、危险因素、肠道微生物群、生态失调、生活方式、预防。

摘要: Dementia is a syndrome resulting from chronic or progressive brain disease. Around 40% of worldwide dementia can be prevented or delayed by modifying 12 risk factors: low educational attainment in early life, mid-life hypertension, mid-life obesity, hearing loss, traumatic brain injury, excessive alcohol consumption, smoking, depression, physical inactivity, social isolation, diabetes mellitus, and air pollution. There is growing evidence that gastrointestinal tract microbiota may significantly contribute to dementia pathogenesis. In particular, gut dysbiosis can trigger metabolic diseases and the progression of low-grade systemic inflammation, being involved in much of the major modifiable risk factors. In this review, we focus on studies that have evaluated the association between modifiable risk factors for dementia and the role of gut microbiota. We also suggest clinical implications for researchers in dementia-gut microbiota related fields.

Cite this article as:

Modifiable Risk Factors for Dementia: The Role of Gut Microbiota, Current Alzheimer Research 2021; 18 (13) . https://dx.doi.org/10.2174/1567205018666211215152411