A Novel Nomogram for Predicting Prognosis after Mechanical Thrombectomy in Patients with Acute Ischemic Stroke

Title:A Novel Nomogram for Predicting Prognosis after Mechanical Thrombectomy in Patients with Acute Ischemic Stroke

Volume: 18 Issue: 5

Author(s): Huiling Sun, Feng Zhou, Guoxing Zhang, Jiankang Hou, Yukai Liu, Xiangliang Chen, Yuqiao Zhang, Wei Wang, Qiwen Deng*, Hongchao Shi*Junshan Zhou*

Affiliation:

• Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006,China

• Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006,China

• Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006,China

Keywords: Acute ischemic stroke, mechanical thrombectomy, bridging therapy, nomogram, clinical outcome.

Abstract: Background: Mounting evidence has shown that mechanical thrombectomy (MT) improves clinical outcomes for large vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS) of the anterior circulation. The present study aimed to provide a comprehensive analysis of risk factors associated with clinical outcomes in AIS patients receiving MT.

Methods: A total of 212 consecutive patients who underwent MT for AIS were enrolled in the present study. Clinical characteristics were recorded at admission. Two endpoints were defined according to the 3-month modified Rankin scale (mRS) score after AIS (good outcome, mRS 0-2; and death, mRS 6). Additionally, we compared the clinical outcomes and safety of MT alone and bridging therapy in AIS patients.

Results: Of the 212 patients treated with MT, 114 (53.77%) patients had a good outcome and 31 (14.62%) died. The incidence of a worse outcome after MT was significantly elevated in males and patients with high WBC counts, high admission blood glucose levels, high baseline NIHSS scores and a long interval time from groin puncture to reperfusion in AIS patients treated with MT after adjustment for covariates (P<0.05); these risk factors were further confirmed by our constructed nomograms. In addition, we observed no significant benefit of bridging therapy compared to MT alone in AIS patients.

Conclusion: Our constructed nomogram based on male sex, admission WBC, admission blood glucose, NIHSS, and the interval time from groin puncture to reperfusion predicts prognosis after mechanical thrombectomy in patients with acute ischemic stroke.

Cite this article as:

Sun Huiling , Zhou Feng , Zhang Guoxing, Hou Jiankang, Liu Yukai , Chen Xiangliang , Zhang Yuqiao, Wang Wei , Deng Qiwen*, Shi Hongchao *, Zhou Junshan *, A Novel Nomogram for Predicting Prognosis after Mechanical Thrombectomy in Patients with Acute Ischemic Stroke, Current Neurovascular Research 2021; 18 (5) . https://dx.doi.org/10.2174/1567202618666211210154739