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Research Article

穿心莲内酯和血管紧张素（1-7）联合应用可协同提高老年小鼠的肌肉功能和力量

卷 22, 期 10, 2022

发表于: 14 January, 2022

页: [908 - 918] 页: 11

弟呕挨: 10.2174/1566524021666211207112106

价格: $65

摘要

背景:骨骼肌减少症是一种进行性和广泛性骨骼肌疾病，其特征为肌肉无力、肌肉质量损失和发力能力下降。衰老会导致肌肉减少症。已经评估了几种治疗策略来预防或减轻这种疾病。其中之一是血管紧张素1-7 [Ang-（1-7）]，这是一种抗骨骼肌萎缩的肽，可以调节多种原因导致的肌肉质量下降，包括衰老。另一种调节肌肉质量和功能的是穿心莲内酯，它是一种双环二萜内酯，可降低核因子kappa B （NF-κB）信号，并减轻某些肌肉疾病的严重程度。 目的:探讨Ang-（1-7）联合穿心莲内酯对衰老性肌肉减少小鼠运动性能、肌力和纤维直径的影响。 方法:老年雄性C57BL/6J小鼠分别给予穿心莲内酯、Ang-（1-7）或联合用药3个月。测量他们的身体表现、肌肉力量和纤维直径。 结果:结果显示老年小鼠（24个月大）经Ang-（1-7）或穿心莲内酯治疗后，与未接受治疗的老年小鼠相比，其跑步机测试表现、肌肉力量和纤维直径均有所改善。Ang-（1-7）与穿心莲内酯联合给药对老年小鼠的身体性能、肌肉力量和纤维直径有增强的协同作用。 结论:我们的结果表明穿心莲内酯和Ang-（1-7）对老龄小鼠肌肉功能、力量和纤维直径的影响增强。

关键词: 肌少症，肾素-血管紧张素系统，虚弱，身体表现，肌肉功能，血管紧张素-（1-7）。

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