Benton 视力保留测试分数与老年人 PET 成像之间的关联

Title:Association between Benton Visual Retention Test Scores and PET Imaging in Elderly Adults

Volume: 18 Issue: 11

关键词: 阿尔茨海默病、benton 视力保留测试、11C-匹兹堡化合物 B 正电子发射断层扫描、18F 氟脱氧葡萄糖-正电子发射断层扫描、轻度认知障碍、统计参数映射。

摘要:

Background: The Benton Visual Retention Test (BVRT) is a well-validated and reliable test for assessing visual memory and visuospatial function. However, the association between the BVRT score and imaging biomarker of Alzheimer’s disease (AD) remains unclear.

Objective: This study examined whether the BVRT score is associated with brain amyloid burden and cortical glucose metabolism in elderly adults without dementia.

Methods: A total of 69 elderly adults without dementia, including 45 subjects with amnestic mild cognitive impairment and 24 cognitively healthy adults, underwent the BVRT and ¹¹C-Pittsburgh compound B (PiB) and ¹⁸F-fluorodeoxyglucose (FDG) positron emission tomography. The correct scores in the BVRT were used for analyses. A multiple linear regression analysis was conducted to investigate the relationship between BVRT scores and PiB or FDG uptake. Moreover, a voxel-wise linear regression analysis of the association between BVRT scores and PiB or FDG uptake was conducted using Statistical Parametric Mapping.

Results: After adjusting for age, sex, education, and ApoE4 status, the BVRT scores were inversely correlated with the mean PiB uptake (β = −0.35, P = 0.003), whereas they were positively correlated with FDG uptake (β = 0.266, P = 0.038). Moreover, the BVRT scores were inversely correlated with amyloid burden in the right superior temporal and superior frontal gyri and the left parietal lobe, whereas they were positively correlated with cortical glucose metabolism in the right posterior cingulate and milled temporal gyri, left temporoparietal lobe, and right superior frontal gyrus.

Conclusion: BVRT scores are correlated with brain amyloid burden and cortical glucose metabolism, mainly in regions commonly affected in AD.

Cite this article as:

Association between Benton Visual Retention Test Scores and PET Imaging in Elderly Adults, Current Alzheimer Research 2021; 18 (11) . https://dx.doi.org/10.2174/1567205018666211207094121