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CNS & Neurological Disorders - Drug Targets

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ISSN (Print): 1871-5273
ISSN (Online): 1996-3181

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Research Article

Evaluation of the Antidepressant-like Effect of Chronic Administration of Nigella Fixed Oil Versus Fluoxetine in Rats

Author(s): Youness Kadil*, Imane Tabyaoui, Latifa Badre, Nadia Tahiri Jouti and Houda Filali

Volume 21, Issue 6, 2022

Published on: 03 December, 2021

Page: [533 - 539] Pages: 7

DOI: 10.2174/1871527320666211201160001

Price: $65

Abstract

Background: Depression is a group of syndromes characterized by notable and persistent mood disorders, and is one of the most prevalent psychiatric disorders, while the existing treatments have an altered risk-benefit balance. The therapeutic properties of Nigella have been confirmed, suggesting the reliance on phytotherapy.

Objectives: The objective of the present paper is to investigate the antidepressive-like effect of Nigella sativa on rats exposed to the Unpredictable Chronic Mild Stress procedure.

Methods: Wistar rats were used to investigate the antidepressive-like effect. The stress procedure used in this study combined many stressful conditions. After 6 weeks of treatment, behavioral test (forced swim test) was conducted, and histological changes of the hippocampus were examined.

Results: Treatment by nigella and fluoxetine significantly reduced the immobilization time. Histopathological analysis showed that control treatments result in more loosely arranged cells, significant apoptotic neurons characterized by an irregular appearance, and pyknotic hyperchromatic.

Conclusion: A preservation of the thickness of the pyramid layer was also observed in the groups treated with nigella and fluoxetine, suggesting that nigella could be used as a treatment or an adjuvant preventing depressive-like disorders.

Keywords: Nigella sativa, fluoxetine, UCMS, histology, depression, antidepressant.

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