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Mini-Reviews in Medicinal Chemistry

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ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

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Review Article

Chromone, A Privileged Scaffold in Drug Discovery: Developments in the Synthesis and Bioactivity

Author(s): Anjitha Theres Benny, Sonia D. Arikkatt , Cijo George Vazhappilly, Sathananthan Kannadasan, Renjan Thomas, Manju Sreedharan Nair Leelabaiamma, Ethiraj Kannatt Radhakrishnan* and Ponnusamy Shanmugam

Volume 22, Issue 7, 2022

Published on: 17 January, 2022

Page: [1030 - 1063] Pages: 34

DOI: 10.2174/1389557521666211124141859

Price: $65

Abstract

Chromones are the class of secondary metabolites that broadly occur in the plant kingdom in a noticeable quantity. This rigid bicyclic system has been categorized “as privileged scaffolds in compounds” in medicinal chemistry. Their wide biological responses have made them an important moiety in a drug discovery program. This review provides updates on the various methods of synthesis of chromones and biological applications in medicinal chemistry. Various synthetic strategies for the construction of chromones include readily available phenols, salicylic acid and its derivatives, ynones, chalcones, enaminones, and 2-hydroxyarylalkylketones as starting materials. Synthesis of chromones by using metal, metal-free, nanomaterials and different other catalysts is herein included. Details of diverse biological activities of chromone derviatives, such as anti-cancer, antimicrobial, anti-viral, anti-inflammatory, antioxidant, as Monoamine Oxidase-B (MAO-B) inhibitors, anti- Alzheimer’s agents, anti-diabetic agents, having antihistaminic potential, and acting as antiplatelet agents, are discussed.

Keywords: Chromones, synthetic transformation, anti-cancer, antimicrobial, anti-diabetic, anti-viral.

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Graphical Abstract

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