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Research Article

HER2阳性胃癌的自噬相关预后标志

卷 22, 期 9, 2022

发表于: 11 January, 2022

页: [809 - 818] 页: 10

弟呕挨: 10.2174/1566524021666211123093532

价格: $65

摘要

背景:自噬相关蛋白（ATGs）的免疫组化分析最近被应用于人类病理学研究分化和癌症进展。本研究的目的是通过5种ATG抗血清（Beclin-1、LC3A/B、p62、ULK-1和AMBRA-1）分析胃癌队列，并评估它们与临床病理参数、HER2状态和患者最终结局的可能关系。 方法:用ATG抗血清对123名GCs进行研究，采用Masuda的标准，确定阳性病例，其中至少有2 / 5的蛋白表达被记录。 结果:自噬的免疫组化标志（A-IHC）为49.59%。A-IHC的比例从低粘连癌的31%到腺癌的56%不等。各ATG免疫标记物对LC3A/B、Beclin-1和p62的敏感性、特异性和效率均较高。单因素分析GC、分级、分期、Ki67表达、HER2状态及A-IHC均为高p值（p < 0.001）。最后，在多变量分析中，HER2状态、分期和A-IHC成为独立的预后变量。生存曲线比较中，A-IHC阳性的GC病例生存时间较短，预后较差。 结论:我们假设A-IHC可以作为一种额外的形态学工具来提供预后因素，以识别生存时间较短和预后较差的侵袭性患者。

关键词: 自噬，免疫组化，胃癌，HER2状态，预后，癌症治疗。

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