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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

肽-药物偶联物开发的进展和策略：针对癌症管理的药代动力学调节、作用和临床证据

卷 22, 期 4, 2022

发表于: 20 January, 2022

页: [286 - 311] 页: 26

弟呕挨: 10.2174/1568009621666211118111506

价格: $65

摘要

目前，许多新的治疗策略正被用于癌症的管理。其中，基于肽的化学疗法由于肽的独特特性而备受关注。这篇综述讨论了肽和肽类似物在癌症治疗中的作用，特别强调了它们的药代动力学调节和研究进展。肽连接的药物缀合物的低分子量、靶向药物递送、增强的渗透性等导致癌症治疗的有效性增加。最近开发了各种肽作为药物和疫苗，具有改变的药代动力学参数，随后在临床研究的不同阶段进行了评估。肽在癌症治疗和诊断领域产生了巨大的影响。使用肽的靶向化疗和药物递送技术正在成为减少常规化疗问题的优秀工具。可以得出结论，不同的临床研究表明，利用肽治疗不同类型癌症的新进展表明，由于肽的新优势，肽可以作为治疗癌症的理想治疗方法。识别和合成新型肽的发展可以为癌症患者提供一个有希望的选择。

关键词: 药代动力学、肽、癌症治疗、临床研究、靶向递送、细胞靶向。

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