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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Mini-Review Article

最先进的技术：结直肠癌中的外泌体

卷 22, 期 1, 2022

发表于: 27 January, 2022

页: [2 - 17] 页: 16

弟呕挨: 10.2174/1568009621666211110094442

价格: $65

摘要

结直肠癌（CRC）在全球范围内具有很高的患病率和死亡率。 迄今为止，CRC的进展机制仍然难以捉摸。 外泌体（直径约 100 nm）对应于由癌细胞和基质细胞阵列形成的细胞外囊泡子集。 这些特殊的纳米囊泡携带和传输生物活性分子，如蛋白质、脂质和遗传物质，它们介导癌细胞与微环境之间的串扰。 越来越多的证据表明外泌体在结直肠癌的发展、转移和治疗抵抗中具有决定性作用。 此外，最近的一些研究还揭示了外泌体作为 CRC 的生物标志物或治疗靶点的能力。 本综述重点关注外泌体调节结直肠癌进展的具体机制，并总结外泌体在结直肠癌诊断和治疗中的潜在临床应用。

关键词: 结直肠癌、外泌体、肿瘤发生、转移、治疗抗性、生物标志物

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