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Review Article

多酚在与氧化应激相关的衰老和神经变性中的作用

卷 29, 期 6, 2022

发表于: 12 January, 2022

页: [1045 - 1060] 页: 16

弟呕挨: 10.2174/0929867328666211101100632

价格: $65

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摘要

衰老被定义为随着时间的推移组织和器官的功能丧失。这是一个生物的、不可逆的、渐进的和普遍的过程，由遗传和环境因素导致，如饮食、体育活动、吸烟、有害饮酒和接触毒素等。衰老是随着时间的推移积累的分子和细胞损伤的结果。这种损害始于身体和心理能力的逐渐下降，从而增加了阿尔茨海默病和帕金森病等神经退行性疾病的风险。神经元、功能和结构损伤可以用自由基、活性氧、活性氮和抗氧化剂之间的不平衡来解释，最终导致氧化应激。由于自由基、活性氧和活性氮的关键作用，抗氧化疗法可以减少与神经退行性变相关的氧化损伤。外源性抗氧化剂是可以帮助维持自由基形成和消除之间平衡的分子，从而保护细胞免受其毒性。其中，多酚是一类广泛的植物次生代谢产物，具有强大的抗氧化特性。在这里，我们回顾了几项研究，这些研究显示了多酚消耗在预防或减缓与神经退行性疾病相关的有害氧化过程方面的潜在作用。

关键词: 衰老、氧化应激、神经退行性疾病、抗氧化剂、多酚、神经保护。

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