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Current Vascular Pharmacology

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ISSN (Print): 1570-1611
ISSN (Online): 1875-6212

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Research Article

Epicardial Adipocyte-derived TNF-α Modulates Local Inflammation in Patients with Advanced Coronary Artery Disease

Author(s): Nikoleta Karampetsou , Aspasia Tzani*, Ilias P. Doulamis, Evanthia Bletsa, Aggeliki Minia, Vaia Pliaka , Nikos Tsolakos, Evangelos Oikonomou , Dimitris Tousoulis , Konstantinos Kontzoglou , Leonidas G. Alexopoulos, Despoina N. Perrea , Paulos Patapis and Ioannis A. Chloroyiannis

Volume 20, Issue 1, 2022

Published on: 29 October, 2021

Page: [87 - 93] Pages: 7

DOI: 10.2174/1570161119666211029110813

Price: $65

Abstract

Background: Epicardial Adipose Tissue (EAT) surrounds the epicardium and can mediate harmful effects related to Coronary Artery Disease (CAD).

Objective: We explored the regional differences between adipose stores surrounding diseased and non-diseased segments of coronary arteries in patients with advanced CAD.

Methods: We enrolled 32 patients with known CAD who underwent coronary artery bypass graft (CABG) surgery. Inflammatory mediators were measured in EAT biopsies collected from a region of the Left Anterior Descending Artery (LAD) with severe stenosis (diseased segment) and without stenosis (non-diseased segment).

Results: Mean age was 64.3±11.1 years, and mean EAT thickness was 7.4±1.9 mm. Dyslipidemia was the most prevalent comorbidity (81% of the patients). Out of a total of 11 cytokines, resistin (p=0.039), matrix metallopeptidase 9 (MMP-9) (p=0.020), C-C motif chemokine ligand 5 (CCL-5) (p=0.021), and follistatin (p=0.038) were significantly increased in the diseased compared with the non-diseased EAT segments. Indexed tumor necrosis factor-alpha (TNF-α), defined as the diseased to non-diseased cytokine levels ratio, was significantly correlated with increased EAT thickness both in the whole cohort (p=0.043) and in a subpopulation of patients with dyslipidemia (p=0.009). Treatment with lipid-lowering agents significantly decreased indexed TNF-α levels (p=0.015). No significant alterations were observed in the circulating levels of these cytokines with respect to CAD-associated comorbidities.

Conclusion: Perivascular EAT is a source of cytokine secretion in distinct areas surrounding the coronary arteries in patients with advanced CAD. Adipocyte-derived TNF-α is a prominent mediator of local inflammation.

Keywords: Epicardial adipose tissue, coronary artery disease, coronary artery bypass graft surgery, inflammation, TNF-α, IL-1α.

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[1]
Massalha S, Walpot J, Dey D, et al. Epicardial adipose tissue: An independent predictor of post-operative adverse cardiovascular events (CTA VISION substudy). JACC Cardiovasc Imaging 2020; 13(3): 882-4.
[http://dx.doi.org/10.1016/j.jcmg.2019.09.017] [PMID: 31734207]
[2]
Foldyna B, Zeleznik R, Eslami P, et al. Epicardial adipose tissue in patients with stable chest pain: Insights from the PROMISE trial. JACC Cardiovasc Imaging 2020; 13(10): 2273-5.
[http://dx.doi.org/10.1016/j.jcmg.2020.05.024] [PMID: 32861649]
[3]
Libby P, Ridker PM, Maseri A. Inflammation and atherosclerosis. Circulation 2002; 105(9): 1135-43.
[http://dx.doi.org/10.1161/hc0902.104353] [PMID: 11877368]
[4]
Packer M. Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium. J Am Coll Cardiol 2018; 71(20): 2360-72.
[http://dx.doi.org/10.1016/j.jacc.2018.03.509] [PMID: 29773163]
[5]
Fuster JJ, Ouchi N, Gokce N, Walsh K. Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease. Circ Res 2016; 118(11): 1786-807.
[http://dx.doi.org/10.1161/CIRCRESAHA.115.306885] [PMID: 27230642]
[6]
Zhao YX, Zhu HJ, Pan H, et al. Comparative proteome analysis of epicardial and subcutaneous adipose tissues from patients with or without coronary artery disease. Int J Endocrinol 2019; 2019: 6976712.
[http://dx.doi.org/10.1155/2019/6976712] [PMID: 31534454]
[7]
Iacobellis G. Local and systemic effects of the multifaceted epicardial adipose tissue depot. Nat Rev Endocrinol 2015; 11(6): 363-71.
[http://dx.doi.org/10.1038/nrendo.2015.58] [PMID: 25850659]
[8]
Bettencourt N, Toschke AM, Leite D, et al. Epicardial adipose tissue is an independent predictor of coronary atherosclerotic burden. Int J Cardiol 2012; 158(1): 26-32.
[http://dx.doi.org/10.1016/j.ijcard.2010.12.085] [PMID: 21255849]
[9]
Song Y, Song F, Wu C, Hong Y-X, Li G. The roles of epicardial adipose tissue in heart failure. Heart Fail Rev 2020.
[http://dx.doi.org/10.1007/s10741-020-09997-x]
[10]
Mazurek T, Zhang L, Zalewski A, et al. Human epicardial adipose tissue is a source of inflammatory mediators. Circulation 2003; 108(20): 2460-6.
[http://dx.doi.org/10.1161/01.CIR.0000099542.57313.C5] [PMID: 14581396]
[11]
Ridker PM, Danielson E, Fonseca FAH, et al. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med 2008; 359(21): 2195-207.
[http://dx.doi.org/10.1056/NEJMoa0807646] [PMID: 18997196]
[12]
González N, Moreno-Villegas Z, González-Bris A, Egido J, Lorenzo Ó. Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes. Cardiovasc Diabetol 2017; 16(1): 44.
[http://dx.doi.org/10.1186/s12933-017-0528-4] [PMID: 28376896]
[13]
Katsiki N, Mikhailidis DP, Wierzbicki AS. Epicardial fat and vascular risk: A narrative review. Curr Opin Cardiol 2013; 28(4): 458-63.
[http://dx.doi.org/10.1097/HCO.0b013e3283605fba] [PMID: 23591557]
[14]
Li Y, Liu B, Li Y, et al. Epicardial fat tissue in patients with diabetes mellitus: A systematic review and meta-analysis. Cardiovasc Diabetol 2019; 18(1): 3.
[http://dx.doi.org/10.1186/s12933-019-0807-3] [PMID: 30630489]

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