Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders

Title:Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders

Volume: 18 Issue: 10

Author(s): Chi H. Poon, Ka C. Tsui, Sze C. Chau, Pit S. Chong, Sylvia W.Y. Lui, Luca Aquili, Kah H. Wong and Lee W. Lim*

Affiliation:

• Neuromodulation Laboratory, School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR,China

Keywords: Nitric oxide synthase, Alzheimer's disease, mood disorders, Huntington's disease, Parkinson's disease.

Abstract: Nitric oxide synthase (NOS) is well known for its involvement in the regulation of the nervous, cardiovascular, and immune systems. Neuronal NOS (nNOS) is the most characterized NOS among all the isoforms. It accounts for most of the production of nitric oxide (NO) in the nervous system required for synaptic transmission and neuroplasticity. Previous studies have described the localization of nNOS in specific brain regions of interest. There is substantial evidence in the literature suggesting that nNOS signaling has significant involvement in several disease pathologies. However, the association between brain nNOS expression profiles and disease remains largely unknown. In this review, we attempt to delineate the contribution of nNOS signaling in memory and mood disorders in order to achieve a better understanding of nNOS in disease modulation.

Cite this article as:

Poon H. Chi , Tsui C. Ka , Chau C. Sze, Chong S. Pit , Lui W.Y. Sylvia , Aquili Luca, Wong H. Kah and Lim W. Lee *, Functional Roles of Neuronal Nitric Oxide Synthase in Neurodegenerative Diseases and Mood Disorders, Current Alzheimer Research 2021; 18 (10) . https://dx.doi.org/10.2174/1567205018666211022164025