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Research Article

人脐带间充质干细胞移植对雌性小鼠生育能力恢复的影响

卷 22, 期 4, 2022

发表于: 26 November, 2021

页: [319 - 330] 页: 12

弟呕挨: 10.2174/1566523221666211014165341

价格: $65

摘要

背景:女性生育能力是指女性产生卵母细胞、实现受精和怀孕的能力，受年龄、疾病、环境和社会压力的影响。然而，目前还没有有效的治疗方法来恢复女性的生殖能力。间充质基质细胞（MSCs）具有多向分化的潜能，作为一种恢复女性生育能力的工具已引起了广泛的关注。方法:本研究采用人脐带- MSCs（Huc-MSCs），通过拯救卵巢功能和重建输卵管和子宫，恢复衰老雌性小鼠和化疗损伤小鼠的生育能力。在我们的研究中，产生了两种小鼠模型:衰老小鼠（35周龄）和化疗损伤小鼠。结果:通过分析性腺激素水平，并进行形态学和统计学分析，评估MSCs对卵巢、输卵管和子宫的影响。在衰老小鼠和化疗小鼠中，Huc-MSC移植后雌二醇（E2）和卵泡刺激素（FSH）水平均显著恢复。Huc-MSC处理还增加了小鼠卵巢中原始卵泡、发育中卵泡和排卵前卵泡的数量。此外，间充质干细胞还通过输卵管纤毛再生、子宫腺体和子宫内膜组织重建等机制拯救输卵管和子宫的形态。结论:Huc-MSCs可能是一种恢复女性生育能力的有效治疗方法，可从化疗损伤中恢复，挽救女性生殖器官免受衰老的影响。

关键词: 女性生殖、间充质干细胞、衰老、化疗、小鼠、间充质基质细胞（MSCs）。

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