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Mini-Reviews in Medicinal Chemistry

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Mini-Review Article

Synthetic Approach to Potential Anticancer Benzimidazole Derivatives: A Review

Author(s): Rajnish Kumar*, Chanchal Singh, Avijit Mazumder, Salahuddin, Md. Mustaqeem Abdullah, Vivek Kumar and Pavan Prakash Giri

Volume 22, Issue 9, 2022

Published on: 07 January, 2022

Page: [1289 - 1304] Pages: 16

DOI: 10.2174/1389557521666211001122118

Price: $65

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Abstract

Cancer is one of the deadliest diseases in many developed and developing countries. Continuous efforts are required for designing better therapeutic agents for the treatment of cancer with more efficacy, selectivity, and less toxicity. The fused heterocyclic ring system has been identified by several researchers as a privileged structure that can be used as the basis for drug discovery in medicinal chemistry. The hetero-aromatic bicyclic ring system acts as a pharmacophore in a wide range of drugs with therapeutic potential. According to studies in the literature, various substituted benzimidazoles have distinct pharmacological profiles with multi-targeting ability, making them an important anchor for the production of novel therapeutic agents against complex cancers, including breast cancer, skin cancer, and blood cancer. In this article, we have discussed various synthetic methods for the synthesis of anti-cancer benzimidazoles and their derivatives in different solvent conditions, substrates, and various catalysts, mainly those which are eco-friendly and economical. We also focused on various derivatives those are under clinical trials containing benzimidazole moiety.

Keywords: Anticancer, benzimidazole, derivatives, synthesis, amidine, bicyclic ring, cancer.

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