Nio Nanoparticles: A Highly Efficient Catalyst for the One-Pot Three- Component Synthesis of Pyrano [2, 3-D] Pyrimidine Derivatives in Green Reaction Media

Title:Nio Nanoparticles: A Highly Efficient Catalyst for the One-Pot Three- Component Synthesis of Pyrano [2, 3-D] Pyrimidine Derivatives in Green Reaction Media

Volume: 19 Issue: 7

Author(s): Ellahe Sabbaghnasab and Enayatollah Sheikhhosseini*

Affiliation:

• Department of Chemistry, Kerman Branch, Islamic Azad University, Kerman, Iran

Keywords: NiO nanoparticles, pyrano pyrimidines, barbituric acid, multicomponent reaction, green synthesis, microwave irradiation.

Abstract: NiO nanoparticles are utilized to effectively strengthen annulated pyrano [2,3-d] pyrimidine synthesis through primary Knoevenagel, following Micheal and ultimate heterocyclization reactions of aldehyde, malononitrile, and barbituric acid. The characteristics of NiO nanoparticles are identified using advanced techniques, such as IR, UV, EDX, XRD, SEM, and TEM. The nano-NiO particles are mostly below < 100 nm in size with uniform spherical shapes. The adopted approach is advantages owing to its simple processing, relatively short reaction time, often good to high average yields, convenient workability, and environmental friendliness.

Cite this article as:

Sabbaghnasab Ellahe and Sheikhhosseini Enayatollah *, Nio Nanoparticles: A Highly Efficient Catalyst for the One-Pot Three- Component Synthesis of Pyrano [2, 3-D] Pyrimidine Derivatives in Green Reaction Media, Letters in Organic Chemistry 2022; 19 (7) . https://dx.doi.org/10.2174/1570178618666211001115655