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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

基于加权相位滞后指数的功能连接改变：阿尔茨海默病的探索性脑电图研究

卷 18, 期 6, 2021

发表于: 01 October, 2021

页: [513 - 522] 页: 10

弟呕挨: 10.2174/1567205018666211001110824

价格: $65

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摘要

目的：许多脑电图 (EEG) 研究关注阿尔茨海默病 (AD) 患者的电活动改变，但没有一致的结果，尤其是在功能连接方面。我们假设加权相位滞后指数（w-PLI）作为功能连接的基于相位的度量，可以用作 AD 的辅助诊断方法。 方法：我们招募了 30 名 AD 患者、30 名轻度认知障碍 (MCI) 患者和 30 名健康对照 (HC)。在放松清醒期间，所有参与者的基线脑电图都被记录下来。在 EEG 预处理之后，确定了功率谱密度 (PSD) 和 wPLI 参数，以进一步分析它们是否与认知评分相关。 结果：在AD患者中，与MCI和HC组相比，θ波段PSD增加，这与定向、计算和延迟记忆容量的障碍有关。此外，wPLI 显示，对于 AD 患者，delta 波段中额叶和远处区域之间的连接强度明显较低，而 theta 波段中中央和颞枕区的连接强度较高。此外，我们发现 theta 功能连接与认知评分之间存在显着的负相关。 结论：增加的 theta PSD 和减少的 delta wPLI 可能是 AD 最早的变化之一，并且与疾病的严重程度有关。参数 wPLI 是一种新颖的相位同步测量方法，具有理解潜在功能连接性和帮助诊断 AD 的潜力。

关键词: 阿尔茨海默病、轻度认知障碍、脑电图、功率谱密度、加权相位滞后指数、认知评分。

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